Interleukin 5 regulates the isoform expression of its own receptor α-subunit

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Eosinophilic Inflammation in Asthma

1990 • 2,535 citations

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

1996 • 1,382 citations

Recombinant human interleukin 5 is a selective activator of human eosinophil function.

1988 • 976 citations

Interleukin-5, eosinophils, and disease

1992 • 874 citations

Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma.

1991 • 841 citations

Allergic and Nonallergic Asthmatics Have Distinct Patterns of T-Cell Activation and Cytokine Production in Peripheral Blood and Bronchoalveolar Lavage

1992 • 788 citations

Interleukin-5, eosinophils, and disease

1992 • 771 citations

The eosinophil and bronchial asthma: Current understanding

1990 • 688 citations

Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF

1989 • 676 citations

Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors

1991 • 617 citations

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

1991 • 598 citations

IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell Responses

1996 • 595 citations

Eosinophilia in transgenic mice expressing interleukin 5.

1990 • 579 citations

Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors.

1988 • 528 citations

Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory.

1991 • 406 citations

Effects of an antibody to interleukin-5 in a monkey model of asthma.

1995 • 335 citations

Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma

1993 • 259 citations

Allergen-induced increases in IL-5 receptor alpha-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects. A novel marker of progenitor cell commitment towards eosinophilic differentiation.

1997 • 242 citations

Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni.

1990 • 238 citations

Hematopoiesis in mice lacking the entire granulocyte-macrophage colony- stimulating factor/interleukin-3/interleukin-5 functions

1996 • 217 citations

Relationship between IL-4 and IL-5 mRNA Expression and Disease Severity in Atopic Asthma

1997 • 206 citations

Mechanisms of Acute Eosinophil Mobilization from the Bone Marrow Stimulated by Interleukin 5: The Role of Specific Adhesion Molecules and Phosphatidylinositol 3-Kinase

1998 • 204 citations

Differential Regulation of Eosinophil Chemokine Signaling Via CCR3 and Non-CCR3 Pathways

1999 • 173 citations

Scatchard plot: Common misinterpretation of binding experiments

1980 • 169 citations

The intracellular signal transduction mechanism of interleukin 5 in eosinophils: the involvement of lyn tyrosine kinase and the Ras-Raf-1-MEK-microtubule-associated protein kinase pathway.

1995 • 168 citations

CD34⁺/Interleukin-5R α Messenger RNA⁺Cells in the Bronchial Mucosa in Asthma: Potential Airway Eosinophil Progenitors

1999 • 148 citations

GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cells

1992 • 142 citations

Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit.

1992 • 140 citations

The activation of the Jak-STAT 1 signaling pathway by IL-5 in eosinophils.

1995 • 131 citations

Src Homology 2 Protein Tyrosine Phosphatase (SHPTP2)/Src Homology 2 Phosphatase 2 (SHP2) Tyrosine Phosphatase Is a Positive Regulator of the Interleukin 5 Receptor Signal Transduction Pathways Leading to the Prolongation of Eosinophil Survival

1997 • 93 citations

Characterization of interleukin 5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells.

1990 • 86 citations

Membrane-bound and soluble alpha IL-5 receptor mRNA in the bronchial mucosa of atopic and nonatopic asthmatics.

1997 • 85 citations

IL-4- and IL-5-secreting lymphocyte populations are preferentially stimulated by parasite-derived antigens in human tissue invasive nematode infections.

1993 • 83 citations

Transcriptional Activation of egr-1 by Granulocyte-Macrophage Colony-stimulating Factor but Not Interleukin 3 Requires Phosphorylation of cAMP Response Element-binding Protein (CREB) on Serine 133

1995 • 68 citations

Interleukin-5 Expression in the Bone Marrow of Sensitized Balb/c Mice after Allergen Challenge

1998 • 63 citations

Identification and Characterization of a Functional Promoter Region in the Human Eosinophil IL-5 Receptor α Subunit Gene

1995 • 50 citations

Expression of Human and Murine Interleukin-5 in Eukaryotic Systems

1989 • 49 citations

Activation of 12-O-Tetradecanoylphorbol-13-acetate Response Element- and Dyad Symmetry Element-dependent Transcription by Interleukin-5 Is Mediated by Jun N-terminal Kinase/Stress-activated Protein Kinase Kinases

1997 • 47 citations

Human B cells express IL-5 receptor messenger ribonucleic acid and respond to IL-5 with enhanced IgM production after mitogenic stimulation with Moraxella catarrhalis.

1996 • 44 citations

A functional bipartite nuclear localisation signal in the cytokine interleukin‐5

1997 • 41 citations

Organization and chromosomal localization of the human interleukin 5 receptor alpha-chain gene.

1992 • 33 citations

Evidence for a signaling role for the alpha chains of granulocyte- macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors: divergent signaling pathways between GM-CSF/IL-3 and IL-5

1995 • 33 citations

Selective inhibition of IL-5 receptor alpha-chain gene transcription by IL-5, IL-3, and granulocyte-macrophage colony-stimulating factor in human blood eosinophils.

1998 • 29 citations

Focal Adhesion Kinase Upregulated by Granulocyte-Macrophage Colony-Stimulating Factor But Not by Interleukin-3 in Differentiating Myeloid Cells

1997 • 28 citations

Selective Inhibition of IL-5 Receptor α-Chain Gene Transcription by IL-5, IL-3, and Granulocyte-Macrophage Colony-Stimulating Factor in Human Blood Eosinophils

1998 • 23 citations

Relationship between light scattering in flow cytometry and changes in shape, volume, and actin polymerization in human polymorphonuclear leukocytes

1995 • 19 citations

Ectopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line

1998 • 17 citations

Evidence for multiple promoters of the human IL-5 receptor alpha subunit gene: a novel 6-base pair element determines cell-specific promoter function.

1997 • 16 citations