Glucuronide-Forming Enzymes

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

Methods of Biochemical Analysis

1956 • 4,535 citations

The Metabolic Basis of Inherited Disease.

1966 • 547 citations

New Color Reactions for Determination of Sugars in Polysaccharides

1955 • 435 citations

ENZYMATIC FORMATION OF URIDINE DIPHOSPHOGLUCURONIC ACID

1957 • 351 citations

The physiological disposition of H3-epinephrine and its metabolite metanephrine.

1959 • 308 citations

The Biochemistry of Foreign Compounds

1968 • 302 citations

Determination of bilirubin glucuronide and assay of glucuronyltransferase with bilirubin as acceptor

1968 • 277 citations

Hepatic Bilirubin UDP-Glucuronyl Transferase Activity in Liver Disease and Gilbert's Syndrome

1969 • 274 citations

STUDIES ON THE NEONATAL DEVELOPMENT OF THE GLUCURONIDE CONJUGATING 12

1958 • 270 citations

Enhancement of Glucuronide-Conjugating Capacity in a Hyperbilirubinemic Infant Due to Apparent Enzyme Induction by Phenobarbital

1966 • 260 citations

The Solubilization and Partial Purification of a Glucuronyl Transferase from Rabbit Liver Microsomes

1962 • 235 citations

Prolonged Neonatal Unconjugated Hyperbilirubinemia Associated with Breast Feeding and a Steroid, Pregnane-3 (Alpha), 20 (Beta)-Diol, in Maternal Milk That Inhibits Glucuronide Formation In Vitro*

1964 • 221 citations

Studies on the activation in vitro of glucuronyltranferase

1969 • 200 citations

Dual Localization of β-Glucuronidase in Endoplasmic Reticulum and in Lysosomes

1967 • 197 citations

Uridine compounds in glucuronic acid metabolism. 1. The formation of glucuronides in liver suspensions

1954 • 187 citations

Uridyl Transferases and the Formation of Uridine Triphosphate: Enzymic Production of Uridine Triphosphate: Uridine Diphosphoglucose Pyrophosphorolysis

1953 • 182 citations

Comparative biochemistry

1963 • 177 citations

Nucleotide Activation of Liver Microsomal Glucuronidation

1961 • 158 citations

Some factors affecting glucuronide formation in vitro.

1960 • 155 citations

DECREASE OF TOTAL SERUM-BILIRUBIN CONCENTRATION IN NEWBORN INFANTS AFTER PHENOBARBITONE TREATMENT

1968 • 148 citations

The Biosynthesis of Glucuronides

1966 • 146 citations

Steroid Induction of Porphyrin Synthesis in Liver Cell Culture

1968 • 145 citations

Inhibitory effects of beta-diethylaminoethyl diphenylpropylacetate on a variety of drug metabolic pathways in vitro.

1954 • 143 citations

Chemical and Biological Aspects of Steroid Conjugation

1970 • 138 citations

Uridine compounds in glucuronic acid metabolism. 2. The isolation and structure of ‘uridine-diphosphate-glucuronic acid’

1955 • 137 citations

Glucuronide synthesis in foetal liver and other tissues

1959 • 136 citations

Alterations in tissue levels of uridine diphosphate glucose dehydrogenase, uridine diphosphate glucuronic acid pyrophosphatase and glucuronyl transferase induced by substances influencing the production of ascorbic acid

1962 • 126 citations

ABSORPTION AND DISTRIBUTION OF DRUGS

1963 • 123 citations

Spontaneous and detergent activation of a glucuronyltransferase in vitro

1967 • 121 citations

The measurement of glucuronide synthesis by tissue preparations

1949 • 121 citations

Salicylate and Salicyl Conjugates: Fluorimetric Estimation, Biosynthesis and Renal Excretion in Man1

1958 • 119 citations

Bilirubin Metabolism in the Fetus*

1964 • 118 citations

REDUCTION IN CONCENTRATION OF TOTAL SERUM-BILIRUBIN IN OFFSPRING OF WOMEN TREATED WITH PHENOBARBITONE DURING PREGNANCY

1968 • 118 citations

Effect of phenobarbital on the excretion of an exogenous bilirubin load

1967 • 114 citations

Absorption and Distribution of Drugs

1964 • 112 citations

Uridine diphosphate glucuronic acid as glucuronyl donor in the synthesis of ‘ester’, aliphatic and steroid glucuronides

1956 • 102 citations

Glucuronide synthesis in kidney and gastrointestinal tract

1962 • 95 citations

Pathway of Alginic Acid Synthesis in the Marine Brown Alga, Fucus gardneri Silva

1966 • 93 citations

The Comparative Metabolism of Xenobiotics

1968 • 90 citations

INHIBITION OF BILIRUBIN CONJUGATION IN RAT LIVER SLICES BY HUMAN PREGNANCY AND NEONATAL SERUM AND STEROIDS

1958 • 86 citations

Formation and Metabolism of Steroids in the Fetus and Placenta

1967 • 83 citations

ENZYMATIC SYNTHESIS OF N-GLUCOSYLURONIC ACID CONJUGATES

1958 • 80 citations

INCREASE IN LEVELS OF GLUCURONYLATING ENZYMES AND ASSOCIATED RISE IN ACTIVITIES OF MITOCHONDRIAL OXIDATIVE ENZYMES UPON PHENOBARBITAL ADMINISTRATION IN THE RAT

1967 • 73 citations

The phospholipid-dependence of UDP-glucuronyltransferase

1969 • 73 citations

The effect of phenobarbital on hyperbilirubinemia in glucuronyl transferase deficient rats.

1967 • 73 citations

Enhanced biliary excretion of thyroxine glucuronide in rats pretreated with benzpyrene

1968 • 72 citations

Methods of Biochemical Analysis

1955 • 70 citations

Biosynthesis of Uronic Acids by Skin Enzymes

1962 • 69 citations

The formation of bilirubin and p-nitrophenyl glucuronides by rabbit liver

1966 • 69 citations

β-Glucuronidase and the Hydrolysis of Glucuronides

1966 • 67 citations

The Purification and Properties of a Nucleotide Pyrophosphatase of Rat Liver Nuclei

1965 • 60 citations

Studies on bilirubin UDP-glucuronyltransferase

1967 • 60 citations

The submicrosomal distribution of hepatic uridine diphosphate glucuronyltransferases in the rabbit

1968 • 59 citations

Inhibitory Aspects of Bile Secretion

1963 • 59 citations

Ethereal and N-linked glucuronide formation by normal and Gunn rats in vitro and in vivo

1961 • 57 citations

Enzymic formation of oestrone 3-glucuronide by rabbit-liver microsomes

1963 • 57 citations

Studies on Phenolic Steroids in Human Subjects: VI. Biosynthesis of Estriolglucosiduronic Acid-16-¹⁴C by Human Liver1

1964 • 56 citations

Determination of UDPG and UDPGA in tissues

1967 • 55 citations

Metabolism of drugs in isolated rat hepatocytes

1969 • 55 citations

5-Pregnene-3β,20α-diol-3-sulfate-20- (2'-acetamido-2'-deoxy-α-D-glucoside) and 5-Pregnene-3β,20α-diol-3,20-disulfate. Two Novel Urinary Conjugates^*

1967 • 54 citations

REDUCTION OF SERUM-UNCONJUGATED-BILIRUBIN WITH PHENOBARBITONE IN ADULT CONGENITAL NON-HÆMOLYTIC UNCONJUGATED HYPERBILIRUBINÆMIA

1968 • 53 citations

Glucose metabolism in the mucosa of the small intestine. A study of hexokinase activity

1968 • 53 citations

The synthesis of glucuronides by liver slices

1950 • 52 citations

The relationship between glucuronidase and galacturonidase activity in the limpet and in mammalian tissues

1958 • 51 citations

Implication of the Conjugation of Drugs and Other Exogenous Compounds

1966 • 51 citations

Biliary and Urinary Metabolites of Estriol-15-³H-3-sulfate-³⁵S in Women¹

1967 • 49 citations

Significant biochemical effects of hepatocarcinogens in the rat: a review.

1962 • 49 citations

Recent Advances in Bile Pigment Metabolism

1969 • 48 citations

Pregnanediols and Neonatal Hyperbilirubinemia

1966 • 48 citations

BILIRUBIN GLUCURONYL TRANSFERASE ACTIVITY IN LIVER DISEASE.

1964 • 48 citations

Hepatic UDP-glucuronyltransferase in Wistar and Gunn rats - in vitro activation by diethylnitrosamine

1968 • 47 citations

CONJUGATED TESTOSTERONE IN THE BLOOD AND TESTES OF SPAWNED FRASER RIVER SOCKEYE SALMON (ONCORHYNCHUS NERKA)

1963 • 47 citations

Skandia International Symposia

1972 • 46 citations

The mechanism of action of UDPG dehydrogenase

1968 • 45 citations

Enzyme levels of glucuronic acid metabolism in the liver, kidney and intestine of normal and fasted rats

1963 • 45 citations

SOME DIFFERENCES IN THE CONJUGATION OF O-AMINOPHENOL AND P-NITROPHENOL BY THE URIDINE DIPHOSPHATE TRANSGLUCURONYLASE OF MOUSE-LIVER HOMOGENATES

1965 • 45 citations

CLINICAL EXPERIENCE WITH PHENOBARBITONE IN ICTERUS NEONATORUM

1969 • 44 citations

Inhibition of glucuronosyl transferase by steroid hormones

1963 • 43 citations

The synthesis of o-aminophenyl glucuronide in several tissues of the domestic fowl, Gallus gallus, during development

1966 • 43 citations

Re-evaluation of the influence of sex, age pregnancy, and phenobarbital on the activity of UDP-glucuronyl transferase in rat liver.

1969 • 41 citations

Alcoholic Cirrhosis and Other Toxic Hepatopathias.

1972 • 41 citations

Synthesis of glucuronides and of uridine diphosphate glucuronic acid in kidney cortex and gastric mucosa

1959 • 40 citations

FACTORS INFLUENCING PREMATURE INDUCTION OF UDP-GLUCURONYLTRANSFERASE ACTIVITY IN CULTURED CHICK EMBRYO LIVER CELLS

1969 • 40 citations

Studies in detoxication

1943 • 40 citations

Purification and Properties of a Pyrophosphatase from Rat Liver Microsomes Capable of Catalyzing the Hydrolysis of UDP-Glucuronic Acid*

1966 • 40 citations

Reduction in serum bilirubin by phenobarbital in adult unconjugated hyperbilirubinaemia

1968 • 39 citations

Hepatic drug-metabolising enzyme activity and duration of hexobarbitone anaesthesia in barbitone-dependent and withdrawn rats

1968 • 39 citations

Biosynthesis of Uronic Acids by Skin Enzymes

1962 • 38 citations

Formation of C-21 steroid sulphates and glucosiduronates by previable human foetuses perfused with [4-14C]progesterone

1965 • 37 citations

The competitive inhibition of p-nitrophenyl-β-d-glucopyranosiduronic acid synthesis by aliphatic alcohols in vitro

1966 • 36 citations

Variations in glucuronide formation by perinatal liver

1966 • 35 citations

DOES DECONJUGATION OF BILIRUBIN GLUCURONIDE OCCUR IN OBSTRUCTIVE JAUNDICE ?

1968 • 34 citations

Impaired hepatic synthesis of glucuronic acid conjugates in diabetic rats

1967 • 34 citations

β-Glucuronidase activity in the serum and liver of rats administered pesticides and hepatotoxic agents

1969 • 33 citations

Gas-liquid chromatographic separation of human urinary steroid glucuronides

1967 • 33 citations

Activation in vitro and solubilization of glucuronyltransferase (assayed with bilirubin as acceptor) with digitonin

1968 • 33 citations

p-nitrophenylglucuronide formation by homozygous adult Gunn rats

1962 • 33 citations

THE INHIBITION OF THE URIDINE DIPHOSPHATE-TRANSGLUCURONYLASE ACTIVITY OF MOUSE-LIVER HOMOGENATES BY THIOL REAGENTS

1965 • 32 citations

Enhanced glucuronide formation in different tissues following drug administration

1968 • 31 citations

In VitroMetabolism of Estradiol-17βby Human Fetal Liver: Formation of Estriol, 16-Epiestriol, Estrone and an Estriol Glucosiduronic Acid

1962 • 30 citations

Comparative Biochemistry of Detoxification

1964 • 30 citations

The effect of pregnanediol and pregnanediol glucuronide on bilirubin conjugation by rat liver slices.

1965 • 29 citations

COMPARISON OF GLUCURONIDE SYNTHESIS IN DEVELOPING MAMMALIAN AND AVIAN LIVER

1963 • 29 citations

Development of uridine diphosphate-glucuronyltransferase activity in cultures of chick-embryo liver

1967 • 29 citations

Chemistry of D-Glucuronic Acid and Its Glycosides

1966 • 29 citations

Purification of uridine diphosphoglucose dehydrogenase from calf liver

1965 • 28 citations

Reactions of uridine diphosphate sugars catalyzed by enzymes of French-bean leaves

1960 • 27 citations

Partial Purification and Kinetic Properties of a Soluble Estrogen Glucuronyltransferase from Pig Intestine

1969 • 26 citations

Enzymic studies on morphine glucronide synthesis in acutely and chronically morphinized rats.

1960 • 26 citations

The Formation of Estradiol-3-glucuronoside-17α-N-acetylglucosaminide by Rabbit Liver Homogenate^*

1965 • 25 citations

Glucuronide metabolism in plants. 3. Triterpene glucuronides

1956 • 25 citations

Enzymological Aspects of Steroid Conjugation

1970 • 25 citations

METABOLISM OF <scp>d</scp>-GLUCURONOLACTONE IN MAMMALIAN SYSTEMS. 3. FURTHER STUDIES OF <scp>d</scp>-GLUCURONOLACTONE DEHYDROGENASE OF RAT LIVER

1963 • 24 citations

Bile pigment excretion: a comparison of the biliary excretion of bilirubin and bilirubin derivatives.

1966 • 24 citations

Biosynthese von Steroidglucuroniclen durch Rattenlebermikrosomen. Zur Frage des Verhaltens der UDP-Glucuronyl-Transferase-Aktivität unter Nahrungsentzug und im Alloxandiabetes

1966 • 24 citations

Effects of Unconjugated Bilirubin on Bilirubin-UDP-Glucuronyl Transferase Activity in Liver of Newborn Rats

1969 • 23 citations

Excretion of G14-Bilirubin in Newborn Guinea Pigs

1964 • 22 citations

The effect of phenobarbitone treatment of rats and of protein deprivation on the capacity of liver slices to conjugate bilirubin

1969 • 21 citations

Vermehrte Glucuronidierung von Sulfadimethoxin w�hrend und nach Phenobarbitalbehandlung bei Ratten

1964 • 21 citations

INHIBITORS OF BILIRUBIN CONJUGATION IN NEW-BORN INFANT SERUM AND MALE URINE.

1963 • 21 citations

Formation, Metabolism, and Transport of Estrogen Conjugates

1970 • 21 citations

THE METABOLISM OF (14C)-BILIRUBIN IN CONGENITAL NON-HAEMOLYTIC HYPERBILIRUBINAEMIA.

1964 • 20 citations

Solubilization of N-glucuronyl transferase

1965 • 20 citations

THE EXCRETION OF CONJUGATED BILIRUBIN BY THE LIVER CELL1

1966 • 19 citations

Glucuronyl transferase inhibition by steroids

1964 • 19 citations

Ethereal and acyl glucuronide formation in the homozygous Gunn rat

1966 • 19 citations

THERAPY IN CONGENITAL HYPERBILIRUBINEMIA: PHENOBARBITAL AND DIETHYLNICOTINAMIDE

1969 • 18 citations

Bilirubin Conjugation in the Human Fetus

1967 • 18 citations

Bilirubin Conjugation in the Human Fetus

1967 • 18 citations

Charakterisierung und Kinetik einer mikrosomalen UDP-Glucuronat: Testosteron-Glucuronyltransferase beim Menschen

1966 • 18 citations

Effects of Aspartic Acid and Orotic Acid upon Serum Bilirubin Level in Newborn Infants

1966 • 18 citations

Effect of Carbon Tetrachloride Upon Glucuronide Formation by Guinea Pig Liver.

1960 • 18 citations

The Effect of Dietary Cirrhosis and CCl14 Poisoning on Glucuronyl Transferase Activity of Rat Liver

1961 • 18 citations

Assay of hepatic glucuronyl transferase activity using [14C]bilirubin as substrate

1966 • 17 citations

Bilirubin Glucuronide Formation in Developing Guinea Pig Liver

1967 • 17 citations

Formation, Metabolism, and Transport of Estrogen Conjugates

1970 • 16 citations

Détermination de l'acide glycuronique dans les urines humaines normales et pathologiques

1962 • 15 citations

FŒTAL BILIRUBIN CONJUGATION

1969 • 15 citations

Enzymatische Bildung von Östradiol-(17β)-glucuroniden in der Mikrosomen-Fraktion der Kaninchenleber

1966 • 15 citations

CHANGES IN ENZYME ACTIVITY, RELATED TO D-GLUCARIC ACID SYNTHESIS, WITH AGE, PREGNANCY AND MALIGNANCY.

1965 • 14 citations

Glucuronidation of 3-O-methylnoradrenaline, harmalol and some related compounds

1968 • 14 citations

Reinigung und charakterisierung einer löslichen uridin diphosphat-glucuronat: 17β-hydroxysteroid-glucuronyl-transferase beim menschen

1966 • 14 citations

Wirkung von Testosteron und einem Anti-Androgen (Cyproteronacetat) auf die Glucuronidbildung in der Rattenleber

1969 • 14 citations

The effect of diethyaminoethyl diphenylpropylacetic acid (SKF 525-A) on uridine 5'-pyrophosphate glucuronyltransferase

1967 • 13 citations

BILIRUBIN CONJUGATION IN THE NEWBORN

1967 • 13 citations

Bilirubin metabolism.

1969 • 13 citations

Implication of Conjugation of Endogenous Compounds—Steroids and Thyroxine

1966 • 13 citations

Vermehrte Bildung von Bilirubinglucuronid in der Leber w�hrend der Insulin-und Sulfonylharnstoff-Hypoglyk�mie

1968 • 13 citations

Glucuronidation in Rats of Different Ages and Strains

1965 • 13 citations

Studies of Urinary Pregnane-3α,20β-diol During Pregnancy, Post-partum, Lactation and Progesterone Ingestion

1967 • 12 citations

BIOGENESE VON ÖSTRIOL-3-MONOGLUCURONID

1967 • 11 citations

Glucuronic Acid Conjugation of Tetrahydrocortisone and p-Nitrophenol in the Homozygous Gunn Rat

1968 • 11 citations

Studies of Glucuronidation. IV. Evidences of Different Processes for o-Aminophenol and p-Nitrophenol

1968 • 11 citations

Formation of an S-glucuronide by a UDP-glucuronyltransferase and its hydrolysis by β-glucuronidase

1969 • 11 citations

Synthesis of Uridine Diphosphate-Glucuronic Acid.

1962 • 10 citations

Implication of Conjugation of Endogenous Compounds—Bilirubin

1966 • 10 citations

Bilirubin conjugation by hepatic microsomes from adult male guinea pigs

1968 • 10 citations

Enzymatic studies of glucuronide formation in impaired liver. IV. Liver glucuronyl transferase activity and uridine diphosphate glucuronic acid content in viral hepatitis patients.

1962 • 10 citations

Metabolism of Polysaccharides Containing Glucuronic Acid

1966 • 9 citations

URIDINE NUCLEOTIDES IN BRAIN*^†

1968 • 9 citations

The Effect of X-Irradiation on the Conjugation of Steroids by Mouse Liver and Kidney

1963 • 9 citations

Inhibition of hexobarbital metabolism by diethylnitrosanune

1968 • 9 citations

Enzymological Aspects of Steroid Conjugation

1970 • 8 citations

Wirkung von Testosteron und einem Anti-Androgen (Cyproteronacetat) auf die Glucuronidbildung in der Rattenleber

1969 • 7 citations

Enzymatic Studies of Glucuronide Formation in Impaired Liver III. Effects of Carbon Tetrachloride and Ectromelia Virus Infection on Liver Glucuronide Formation in Mouse

1962 • 7 citations

Méthode de dosage de l'activité glucuronyltransférase hépatique applicable en biologie clinique

1967 • 7 citations

Activities of UDPglucose Dehydrogenase, UDPglucuronyl Transferase, and Some Glycosidases of Freshwater Fish during the Adaptation to Salt Water.

1968 • 6 citations

Congenital Non-Hemolytic Jaundice: Crigler-Najjar Syndrome

1969 • 6 citations

Β-Glucuronidase bei akuter Tetrachlorkohlenstoffschädigung der Rattenleber

1967 • 6 citations

METABOLISM OF GLUCURONIC ACID IN FATIGUE DUE TO PHYSICAL EXERCISE

1966 • 6 citations

Die Wirkung von Tolbutamid auf Blutglucose und Glucurons�urekonjugation im Lebergewebe normaler und adrenalektomierter M�use

1969 • 6 citations

The effects of phenobarbitone on the biliary excretion of foreign compounds by the rat

1968 • 4 citations

Metabolites of sulphadimethoxypyrimidine in the urine of various species

1969 • 4 citations

Die Wirkung von Tolbutamid auf Blutglucose und Glucuronsäurekonjugation im Lebergewebe normaler und adrenalektomierter Mäuse

1969 • 4 citations

The Newborn

1969 • 3 citations

Studies on Glucuronide Detoxication Mechanisms in Vitamin A Deficient Rats

1965 • 3 citations

Glucuronide Formation in Parturients

1963 • 2 citations

Synthesis of Uridine Diphosphate-Glucuronic Acid

1960 • 2 citations

Unsere Erfahrungen mit dem OIB-Test (Ein Leberfunktionstest durch Verfolgen des o-Jodbenzoesäure-131J-Stoffwechsels)

1967 • 1 citations