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Enzymological Aspects of Steroid Conjugation

Data up to Jan 2025

Published1970
Citations8
References186

Total Citations Per Year

Abstract

References (186)

Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue

1955 • 4,109 citations

The kinetics of enzyme-catalyzed reactions with two or more substrates or products

1963 • 1,885 citations

Studies on glucosaminidase. 4. The fluorimetric assay of N-acetyl-β-glucosaminidase

1961 • 458 citations

APPLICATION OF AN IMPROVED GLUCURONIDASE ASSAY METHOD TO THE STUDY OF HUMAN BLOOD β-GLUCURONIDASE

1948 • 428 citations

Mammalian glycosidases. Distribution in the body

1959 • 354 citations

ENZYMATIC FORMATION OF URIDINE DIPHOSPHOGLUCURONIC ACID

1957 • 351 citations

The preparation and properties of β-glucuronidase. 4. Inhibition by sugar acids and their lactones

1952 • 320 citations

Enzymatic Reactions Involving Sulfate, Sulfite, Selenate, and Molybdate

1958 • 317 citations

Biological Sulfate Activation and Transfer

1958 • 273 citations

Inhibition of glycosidases by aldonolactones of corresponding configuration. 2. Inhibitors of β-N-acetylglucosaminidase

1958 • 251 citations

The Solubilization and Partial Purification of a Glucuronyl Transferase from Rabbit Liver Microsomes

1962 • 235 citations

Inhibition of glycosidases by aldonolactones of corresponding configuration

1957 • 224 citations

Studies on glucosaminidase. 3. Testicular N-acetyl-β-glucosaminidase and N-acetyl-β-galactosaminidase

1961 • 223 citations

Glycogen metabolism in embryonic chick and neonatal rat liver

1963 • 217 citations

ISOLATION AND IDENTIFICATION OF ACTIVE SULFATE

1957 • 212 citations

Enzymatic Synthesis of Adenosine-5′-Phosphosulfate

1958 • 203 citations

Separation and properties of β-galactosidase, β-glucosidase, β-glucuronidase and N-acetyl-β-glucosaminidase from rat kidney

1967 • 192 citations

The synthesis of bilirubin glucuronide in animal and human liver

1958 • 190 citations

Comparative studies on the liver sulphatases

1958 • 189 citations

Uridine compounds in glucuronic acid metabolism. 1. The formation of glucuronides in liver suspensions

1954 • 187 citations

The formation of bile acid sulfates: a new pathway of bile acid metabolism in humans.

1967 • 185 citations

Separation of the Two Enzymatic Phases in Active Sulfate Synthesis

1958 • 184 citations

Uridyl Transferases and the Formation of Uridine Triphosphate: Enzymic Production of Uridine Triphosphate: Uridine Diphosphoglucose Pyrophosphorolysis

1953 • 182 citations

ENZYMATIC SYNTHESIS OF STEROID SULFATES

1956 • 174 citations

Metabolism of <scp>d</scp>-glucuronolactone in mammalian systems. Identification of <scp>d</scp>-glucaric acid as a normal constituent of urine

1963 • 169 citations

The steroid sulphatase of Patella vulgata

1956 • 165 citations

Separation of Steroid Sulfokinases

1958 • 164 citations

Inhibition of UDP-D-glucose dehydrogenase by UDP-D-xylose: A possible regulatory mechanism

1965 • 148 citations

The Biosynthesis of Glucuronides

1966 • 146 citations

Glucuronide synthesis in foetal liver and other tissues

1959 • 136 citations

Studies on glucosaminidase. N-Acetyl-β-glucosaminidase in rat kidney

1957 • 130 citations

Uridine nucleotide compounds of liver

1954 • 124 citations

Purification of β-N-acetylglucosaminidase from the pig epididymis

1960 • 121 citations

Studies on sulphatases. 12. The arylsulphatases of human tissues

1956 • 117 citations

Uridine diphosphoglucose dehydrogenase of pea seedlings

1957 • 115 citations

The enzymic conversion of glucosamine to galactosamine

1959 • 115 citations

Investigations of the Properties and Mechanism of the Uridine Diphosphate Glucose Pyrophosphorylase Reaction.

1955 • 109 citations

Determination of Mammalian Steroid Sulfatase with 7 α-H3-3 β-Hydroxyandrost-5-en-17-one Sulfate

1963 • 105 citations

Studies on glucosaminidase. 2. Substrates for N-acetyl-β-glucosaminidase

1961 • 103 citations

Uridine diphosphate glucuronic acid as glucuronyl donor in the synthesis of ‘ester’, aliphatic and steroid glucuronides

1956 • 102 citations

Nucleotides Involved in the Enzymatic Conjugation of Phenols with Sulfate

1958 • 98 citations

Glucuronide synthesis in kidney and gastrointestinal tract

1962 • 95 citations

The inhibition of β-glucuronidase by saccharic acid and the role of the enzyme in glucuronide synthesis

1949 • 95 citations

The Sulfatase of Ox Liver. IX. The Polymerization of Sulfatase A*

1965 • 93 citations

Mammalian α-Acetylglucosaminidase. Enzymic Properties, Tissue Distribution, and Intracellular Localization*

1967 • 92 citations

Mammalian glycosidases. 4. The intracellular localization of β-galactosidase, α-mannosidase, β-N-acetylglucosaminidase and α-<scp>l</scp>-fucosidase in mammalian tissues

1963 • 91 citations

Assay of Sulfatases

1957 • 87 citations

STUDIES ON THERMOPHILIC SULFATE-REDUCING BACTERIA III

1962 • 87 citations

The Suiphatase of Ox Liver*

1964 • 87 citations

Oligosaccharase Activity of β-N-Acetyl-d-glucosaminidase of Beef Liver

1964 • 86 citations

Purification of β-glucuronidase from the preputial gland of the female rat

1958 • 85 citations

Distribution of Steroid Sulfatase in Human Tissues

1965 • 84 citations

ENZYMIC CATALYSIS OF GLUCURONYL TRANSFER

1957 • 83 citations

Uridine Diphosphoacetylglucosamine Pyrophosphorylase

1959 • 80 citations

INFLUENCE OF GONADECTOMY, SEX HORMONES AND OTHER FACTORS, ON THE ACTIVITY OF CERTAIN GLYCOSIDASES IN THE RAT AND MOUSE

1959 • 79 citations

PURIFICATION OF URIDINEDIPHOSPHATE GLUCOSE PYROPHOSPHORYLASE FROM MUNG BEAN SEEDLINGS

1958 • 76 citations

Purification and Properties of Human Liver β-Glucuronidase

1965 • 76 citations

Some Stereospecificity Studies with Tritiated Pyridine Nucleotides*

1963 • 74 citations

The Synthesis of α-D-Glucosamine-1-phosphate and N-Acetyl-α-D-glucosamine-1-phosphate. Enzymatic Formation of Uridine Diphosphoglucosamine1

1956 • 74 citations

The sulphatase of ox liver. 6. Steroid sulphatase

1957 • 71 citations

The enzymic synthesis of steroid sulphates

1956 • 70 citations

β-Glucuronidase and the Hydrolysis of Glucuronides

1966 • 67 citations

Studies on β-glucuronidase. 2. The preparation and properties of three ox-spleen β-glucuronidase fractions

1953 • 66 citations

Purification and characterization of bovine liver β-glucuronidase

1966 • 66 citations

Studies on -Glucuronidase from E. coli.

1951 • 62 citations

Uridine diphosphoglucose pyrophosphorylase of pea seeds

1958 • 62 citations

Studies on glucosaminidase. 6. N-Acetyl-β-glucosaminidase and N-acetyl-β-galactosaminidase activities of a variety of enzyme preparations

1961 • 61 citations

Some properties of uridine diphosphoglucose dehydrogenase

1956 • 61 citations

Synthesis of Adenylyl Sulfate and Adenylyl Sulfate 3'-Phosphate

1964 • 60 citations

Studies on glucosaminidase. 5. Kidney N-acetyl-β-glucosaminidase and N-acetyl-β-galactosaminidase

1961 • 60 citations

The sulphatase of ox liver. XI. The isoelectric focussing of a purified preparation of sulphatase B

1968 • 60 citations

Properties of steroid sulphatase and arylsulphatase activities of human placenta

1967 • 59 citations

The biosynthesis of labeled estriol-3-sulfate-16-glucosiduronate

1965 • 59 citations

Vitamin A and the sulfate-activating enzymes

1966 • 59 citations

Ethereal and N-linked glucuronide formation by normal and Gunn rats in vitro and in vivo

1961 • 57 citations

Enzymic formation of oestrone 3-glucuronide by rabbit-liver microsomes

1963 • 57 citations

Studies on Phenolic Steroids in Human Subjects: VI. Biosynthesis of Estriolglucosiduronic Acid-16-14C by Human Liver1

1964 • 56 citations

The Isolation from Rabbit Urine of a Conjugate of 17α-Estradiol with N-Acetylglucosamine

1964 • 56 citations

The use of phenol glucuronide in the assay of β-glucuronidase

1948 • 55 citations

5-Pregnene-3β,20α-diol-3-sulfate-20- (2'-acetamido-2'-deoxy-α-D-glucoside) and 5-Pregnene-3β,20α-diol-3,20-disulfate. Two Novel Urinary Conjugates*

1967 • 54 citations

Observations on the biosynthesis of thiamine in yeast

1966 • 54 citations

Kinetic studies of the phenol sulphotransferase reaction

1968 • 54 citations

The preparation and properties of β-glucuronidase. 6. Activity in rat-liver preparations

1953 • 54 citations

The activation of an arylsulphatase from ox liver by chloride and other anions

1959 • 53 citations

The Comparative Ability of β-Glucuronidase Preparations (Liver, Escherichia coli, Helix pomatia, and Patella vulgata) to Hydrolyze Certain Steroid Glucosiduronic Acids

1961 • 53 citations

Dehydroepiandrosterone Sulfate: A Secretory Product of the Boar Testis

1967 • 53 citations

The relationship between glucuronidase and galacturonidase activity in the limpet and in mammalian tissues

1958 • 51 citations

β-GLUCURONIDASE

1953 • 50 citations

Dissociation and Activation of β-Glucuronidase1

1954 • 50 citations

D-Glucopyranosiduronates. I. Steroidyl-β-D-glucopyranuronosides1,2

1959 • 49 citations

Studies on ester sulfates

1959 • 49 citations

Uridine Diphosphate Glucose Dehydrogenase

1963 • 48 citations

The hydrolysis of glucosaminides by an enzyme in Helix pomatia

1939 • 47 citations

Biosynthesis of steroid sulfates by normal human testis

1965 • 46 citations

DISTRIBUTION OF SOME STEROID SULPHOKINASES IN FOETAL HUMAN TISSUES

1966 • 46 citations

α-GLUCOSAMINIDASE

1951 • 46 citations

SOME DIFFERENCES IN THE CONJUGATION OF O-AMINOPHENOL AND P-NITROPHENOL BY THE URIDINE DIPHOSPHATE TRANSGLUCURONYLASE OF MOUSE-LIVER HOMOGENATES

1965 • 45 citations

mesoInositol in the lens of mammalian eyes

1957 • 44 citations

Identification in Rabbit Urine of the 3-Glucuronoside-17-N-acetylglucosaminide of 17α-Estradiol

1965 • 44 citations

The sulphatase of ox liver. 5. Sulphatase C

1956 • 43 citations

Function of vitamin a in the synthesis of 3′-phosphoadenosine-5′-phosphosulfate

1960 • 42 citations

Über Oestronsulfat, ein physiologisches Ausscheidungsprodukt des Follikelhormons

1939 • 41 citations

[31] Glucuronidases

1955 • 41 citations

Studies on β-glucuronidase. 4. The purification and properties of ox-liver β-glucuronidase

1953 • 41 citations

Purification of β-acetylglucosaminase and β-galactosidase from ram testis

1966 • 40 citations

Steroids of Invertebrates: Production of Oestrogens by an Accessory Reproductive Tissue of the Slug Arion ater rufus (Linn.)

1967 • 40 citations

The activation of sulphate by extracts of cornea and colonic mucosa from normal and vitamin A-deficient animals

1963 • 40 citations

Biosynthesis of Steroid Sulfates by Human Ovarian Tissue

1964 • 39 citations

The uridyl transferase of liver

1954 • 37 citations

The isolation of urinary 17-oxo steroid and corticosteroid glucuronides

1964 • 36 citations

Enzymic synthesis of steroid sulphates I. Sulphation of steroids by human adrenal extracts

1964 • 36 citations

Steroid sulphatase, arylsulphatase and β-glucuronidase in marine invertebrates

1960 • 36 citations

Steroid sulphatase, arylsulphatase and β-glucuronidase in the mollusca

1960 • 35 citations

Sulfur Metabolism of Aerobactor aerogenes II. The Purification and Some Properties of a Sulfatase

1964 • 35 citations

Studies on metabolism of vitamin A. 6. The effect of vitamin A deficiency on the activation of sulphate and its transfer to p-nitrophenol in rat liver

1964 • 34 citations

A method for the estimation of dehydroepiandrosterone in urine

1959 • 34 citations

Steroids of Invertebrates: the in vitro Production of II-Ketotestosterone and Other Steroids by the Eggs of the Slug, Arion ater rufus (Linn.)

1966 • 34 citations

Properties of limpet β-glucuronidase

1957 • 32 citations

Enzymatic sulfation of steroids by bovine tissues

1965 • 32 citations

The formation of cholesteryl sulphate by androstenolone sulphotransferase

1967 • 31 citations

Studies on Ester Sulphates. 14. The in vitro Formation of Steroid Disulphates in Rat Liver Extracts.

1963 • 31 citations

“Activator-competitive” enzyme inhibition. Interrelation of dissociation, activation, inhibition and surface inactivation of β-glucuronidase

1957 • 31 citations

Über Emulsin. XIII. Darstellung und fermentative Spaltung von Glykosiden des N-Acetyl-glucosamins und der 2-Desoxyglucose.

1933 • 31 citations

343. Synthesis of “active sulphate”(adenosine 3′-phosphate 5′-sulphatophosphate)

1959 • 31 citations

Contribution to the study of the structure of the aldosterone-conjugate isolated from human urine

1965 • 31 citations

An electrophoretic investigation of interactions between bovine plasma albumin and charged dextran derivatives

1961 • 30 citations

Glycosulphatase: observations on the activity of partially purified preparations towards the sulphate esters of certain monosaccharides and steroids

1961 • 30 citations

Eine Steroidsulfatase aus Säugetierleber

1956 • 29 citations

The uridyl transferase of mammary gland

1955 • 29 citations

STUDIES ON ESTER SULPHATES

1967 • 29 citations

The mechanism of glucuronide formation

1961 • 28 citations

Comparison of Different Glycosidase Activities in Conditions of Cancer

1957 • 28 citations

The cerimetric determination of glucuronic acid, using the Conway burette

1946 • 28 citations

Formation of UDPGla and Related Compounds by the Soluble Fraction of Liver

1956 • 27 citations

Occurrence of a mammalian α-N-acetyl-d-galactosaminidase

1966 • 27 citations

Action of β-glucuronidase on a steroid-enol-β-glucosiduronic acid

1961 • 26 citations

Enzymic synthesis of steroid sulphates

1967 • 25 citations

Ox spleen β-glucuronidase; its purification and a study of some factors involved in assaying its activity

1946 • 25 citations

The Formation of Estradiol-3-glucuronoside-17α-N-acetylglucosaminide by Rabbit Liver Homogenate*

1965 • 25 citations

Biosynthese von Steroidglucuroniclen durch Rattenlebermikrosomen. Zur Frage des Verhaltens der UDP-Glucuronyl-Transferase-Aktivität unter Nahrungsentzug und im Alloxandiabetes

1966 • 24 citations

The enzymic hydrolysis of steroid conjugates. 1. Sulphatase and β-glucuronidase activity of molluscan extracts

1956 • 24 citations

IN VITROSYNTHESIS OF DEHYDROEPIANDROSTERONE SULFATE1

1955 • 24 citations

HYDROLYSIS OF CONJUGATED SULFATES OF ESTROGENS BY COMMERCIAL ENZYME PREPARATION OF ASPERGILLUS ORYZAE

1949 • 23 citations

Sulfate metabolism in avion and mammalian cartilage extracts

1963 • 22 citations

THE ARYLSULPHATASES AND RELATED ENZYMES IN THE LIVERS OF SOME LOWER VERTEBRATES

1963 • 22 citations

Sulphate Conjugation during Development, in Human, Rat and Guinea Pig

1966 • 21 citations

The synthesis of 3′-phosphoadenosine 5′-phosphosulfate by retinae and livers of normal and vitamin A-deficient rats

1966 • 21 citations

Paradoxical Action of Solvents on Bacterial and Liver β-Glucuronidases

1959 • 20 citations

STUDIES ON ESTER SULPHATES

1964 • 20 citations

ON β-GLUCURONOSIDASE

1936 • 20 citations

Inhibition of β-Glucuronidase by Cholesterol and Retinol

1967 • 20 citations

Steroid glucuronides I. The synthesis of β-d-glucopyranosiduronic acids of 3-hydroxy-androstane-17-ketones

1965 • 19 citations

Action of Copper on Mammalian β-Glucuronidase

1957 • 18 citations

Charakterisierung und Kinetik einer mikrosomalen UDP-Glucuronat: Testosteron-Glucuronyltransferase beim Menschen

1966 • 18 citations

Über Steroid-Konjugate in Plasma, XIII. Isolierung, Eigenschaften und Zusammensetzung eines biosynthetischen, lipophilen Dehydroepiandrosteron-Konjugats

1965 • 17 citations

The extraction and hydrolysis of steroid monoglucuronides

1966 • 17 citations

A glucuronic-decomposing enzyme from rumen micro-organisms. 3. Mode of action, specificity and inhibition by acidic sugar derivatives

1955 • 17 citations

Possible allosteric effects with arylamine sulphokinase

1964 • 16 citations

Die Verbreitung der Aryl- und Steroidsulfatasen

1959 • 16 citations

DEHYDROEPIANDROSTERONE IN BLOOD

1958 • 16 citations

Studies on metabolism of vitamin A. The effect of the stage of vitamin A deficiency on sulphate activation in rat liver

1966 • 16 citations

The enzymic synthesis of aryl sulphamates. 2. The effect of 3β-methoxyandrost-5-en-17-one on arylamine sulphokinase

1961 • 15 citations

Enzymatische Bildung von Östradiol-(17β)-glucuroniden in der Mikrosomen-Fraktion der Kaninchenleber

1966 • 15 citations

Partial purification of a soluble UDPglucuronyltransferase from human intestine

1966 • 15 citations

Duodenal Glucuronide Synthesis. II. Identification of Estradiol Glucuronide as a Conjugation Product of Estradiol by Rat Duodenal Mucosa. Qualitative Studies.

1958 • 15 citations

Metabolism of Drugs. XLV. Synthesis of 2-Naphthyl β-D-Glucofuranosiduronic Acid.

1964 • 15 citations

Zur Bildung wasserlöslicher Metaboliten aus Oestron in Rattenlebermikrosomen

1965 • 14 citations

BIOGENESE VON ÖSTRIOL-16α-MONOGLUCURONID UND ÖSTRIOL-17β-MONOGLUCURONID

1966 • 14 citations

METABOLIC ACTIVITIES OF VITAMIN D IN ANIMALS

1965 • 14 citations

PURIFICATION OF URIDINE DIPHOSPHOGLUCOSE PYROPHOSPHORYLASE FROM HUMAN BRAIN*

1961 • 14 citations

Reinigung und charakterisierung einer löslichen uridin diphosphat-glucuronat: 17β-hydroxysteroid-glucuronyl-transferase beim menschen

1966 • 14 citations

Metabolism of Drugs. XLIV. Glucuronyl Transfer Reaction catalyzed by β-Glucuronidase by the Use of Ester Glucuronides as Substrates.

1964 • 13 citations

Crystalline beta-Glucuronidase.

1964 • 12 citations

Metabolism of Drugs. XLVI. Behavior of 2-Naphthyl β-D-Glucofuranosiduronic Acid toward β-Glucuronidase.

1964 • 12 citations

Glucuronic Conjugation of Steroids in the Avian Adrenal Gland.

1960 • 12 citations

Mammalian Liver β-Glucuronidase for Hydrolysis of Steroidal Conjugates

1960 • 12 citations

Some Properties of the Uridine Diphosphate Glucose Pyrophosphorylase.

1957 • 12 citations

BIOCHEMICAL STUDIES ON CARBOHYDRATES

1936 • 11 citations

3α-Ureido-11β-hydroxy-Δ4-androsten-17-one, a Novel Steroid Transformation in Man

1966 • 11 citations

Studies on a Liver Activator of β-Glucuronidase

1961 • 11 citations

Steroid glucuronides II. The hydrolysis of β-d-glucosiduronic acids by β-glucuronidases

1965 • 10 citations

Purification and properties of β-N-acetylglucosaminidase from bovine uterus

1967 • 10 citations

The enzymic synthesis of aryl sulphamates. 3. The specificity and mechanism of the activation of rat-Liver arylamine sulphokinase by 17-oxo steroids

1962 • 9 citations

Preparation of Substrates for Assay of Sulphotransferases

1962 • 7 citations

Isolation, Characterization, and Synthesis of 3α-Ureido-11β-hydroxy-Δ4-androsten-17-one

1966 • 6 citations

Steroidsulfatase in the Liver of Charonia lampas

1961 • 2 citations

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