DUCTAL CARCINOMA IN SITU

Five-Year Results of a Randomized Clinical Trial Comparing Total Mastectomy and Segmental Mastectomy with or without Radiation in the Treatment of Breast Cancer

1985 • 2,186 citations

Risk Factors for Breast Cancer in Women with Proliferative Breast Disease

1985 • 1,817 citations

American Cancer Society Guidelines for the Early Detection of Cancer

2002 • 1,652 citations

Eight-Year Results of a Randomized Clinical Trial Comparing Total Mastectomy and Lumpectomy with or without Irradiation in the Treatment of Breast Cancer

1989 • 1,604 citations

Neu-Protein Overexpression in Breast Cancer

1988 • 860 citations

Lumpectomy Compared with Lumpectomy and Radiation Therapy for the Treatment of Intraductal Breast Cancer

1993 • 832 citations

Pathologic findings from the national surgical adjuvant breast project (protocol 6) I. Intraductal carcinoma (DCIS)

1986 • 829 citations

Association of p53 Protein Expression With Tumor Cell Proliferation Rate and Clinical Outcome in Node-Negative Breast Cancer

1993 • 777 citations

Breast Cancer Detection Demonstration Project: Five-Year Summary Report

1982 • 706 citations

A prognostic index for ductal carcinoma in situ of the breast

1996 • 699 citations

Intraductal carcinoma of the breast: Follow-up after biopsy only

1982 • 604 citations

Incidence of and Treatment for Ductal Carcinoma In Situ of the Breast

1996 • 600 citations

Evidence on screening for breast cancer from a randomized trial

1977 • 580 citations

Mammographically detected duct carcinoma in situ. Frequency of local recurrence following tylectomy and prognostic effect of nuclear grade on local recurrence

1989 • 563 citations

HER-2/neu in node-negative breast cancer: prognostic significance of overexpression influenced by the presence of in situ carcinoma.

1992 • 466 citations

DISEASES OF THE BREAST

1957 • 448 citations

Continued local recurrence of carcinoma 15–25 years after a diagnosis of low grade ductal carcinoma in situ of the breast treated only by biopsy

1995 • 432 citations

Overexpression of HER-2/neu and its relationship with other prognostic factors change during the progression of in situ to invasive breast cancer

1992 • 415 citations

Breast cancer and atypia among young and middle-aged women: a study of 110 medicolegal autopsies

1987 • 411 citations

Duct carcinoma in situ . Relationship of extent of noninvasive disease to the frequency of occult invasion, multicentricity, lymph node metastases, and short‐term treatment failures

1982 • 362 citations

The clinical significance of pre-invasive breast carcinoma

1980 • 345 citations

On the Origin and Progression of Ductal Carcinoma in the Human Breast2

1973 • 345 citations

Duct carcinomain situ. Relationship of extent of noninvasive disease to the frequency of occult invasion, multicentricity, lymph node metastases, and short-term treatment failures

1982 • 344 citations

The natural history of breast carcinoma: what have we learned from screening?

1999 • 342 citations

Using Autopsy Series To Estimate the Disease “Reservoir” for Ductal Carcinoma in Situ of the Breast: How Much More Breast Cancer Can We Find?

1997 • 339 citations

Analysis of Loss of Heterozygosity in 399 Premalignant Breast Lesions at 15 Genetic Loci

1998 • 338 citations

Bilateral primary breast cancers.A prospective clinicopathological study

1964 • 334 citations

Comparative genomic hybridization of ductal carcinomain situ of the breast?evidence of multiple genetic pathways

1999 • 334 citations

Intraductal carcinoma. Long-term follow-up after treatment by biopsy alone

1978 • 308 citations

Survival Experience in The Breast Cancer Detection Demonstration Project

1987 • 304 citations

Long-term follow-up of in situ carcinoma of the breast.

1994 • 300 citations

Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro

1990 • 283 citations

The c-erbB-2 proto-oncogene as a prognostic and predictive marker in breast cancer: A paradigm for the development of other macromolecular markers-A review

1995 • 260 citations

Heterogeneity of intraductai carcinoma of the breast

1989 • 250 citations

Ductal Carcinoma in Situ (Intraductal Carcinoma) of the Breast

1988 • 242 citations

Intraductal carcinoma of the breast (208 cases): Clinical factors influencing treatment choice

1990 • 221 citations

Early phases in the development of breast cancer

1969 • 212 citations

Association of atypical characteristics of benign breast lesions with subsequent risk of breast cancer

1972 • 210 citations

American Cancer Society guidelines for the early detection of cancer

2000 • 205 citations

Subclinical ductal carcinoma in situ of the breast: Treatment by local excision and surveillance alone

1992 • 200 citations

Estrogen and progesterone receptors in the normal female breast.

1991 • 196 citations

The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast.

1992 • 196 citations

Conservation therapy for breast cancers other than infiltrating ductal carcinoma

1989 • 194 citations

The study of mammary carcinoma by mammography and whole organ sectioningearly observations

1969 • 179 citations

Ductal carcinoma in situ of the breast. Heterogeneity of individual lesions

1994 • 178 citations

Intraductal carcinoma of the breast

1975 • 177 citations

Medical audit of a rapid-throughput mammography screening practice: methodology and results of 27,114 examinations.

1990 • 174 citations

The prevalence of carcinoma in situ in normal and cancer-associated breasts

1985 • 173 citations

Increases in Ductal Carcinoma In Situ (DCIS) of the Breast in Relation to Mammography: A Dilemma

1997 • 169 citations

The Consensus Conference on the Treatment of In Situ Ductal Carcinoma of the Breast, April 22-25, 1999

2000 • 167 citations

Prevalence of benign, atypical, and malignant breast lesions in populations at different risk for breast cancer. A forensic autopsy study

1987 • 166 citations

Genetic divergence in the clonal evolution of breast cancer.

1996 • 164 citations

Immunohistochemical demonstration of c-erbB-2 protein in mammary ductal carcinoma in situ

1990 • 163 citations

Allelotyping of ductal carcinoma in situ of the breast: deletion of loci on 8p, 13q, 16q, 17p and 17q.

1995 • 162 citations

Ductal Carcinoma In Situ of the Female Breast

1992 • 162 citations

p53 protein expression in mammary ductal carcinoma in situ: Relationship to immunohistochemical expression of estrogen receptor and c-erbB-2 protein

1993 • 157 citations

Mutations in Human Breast Cancer: An Overview

1989 • 155 citations

Noninvasive Breast Carcinoma

1979 • 155 citations

Duct carcinoma in situ: 227 cases without microinvasion

1992 • 153 citations

The p53 tumor suppressor gene in breast cancer

1994 • 151 citations

Carcinoma in situ of the breast

1977 • 147 citations

Mammographically-detected ductal in situ carcinoma of the breast analyzed with a new classification. A study of 127 cases: correlation with estrogen and progesterone receptors, p53 and c-erbB-2 proteins, and proliferative activity.

1994 • 147 citations

Expression of p53 protein in infiltrating and in‐situ breast carcinomas

1991 • 145 citations

Precancerous and cancerous breast lesions during lifetime and at autopsy. A study of 83 women

1984 • 145 citations

Twenty-year follow-up of the breast cancers diagnosed during the Breast Cancer Detection Demonstration Project

1997 • 139 citations

Lobular Carcinoma In Situ of the Female Breast

1993 • 138 citations

Ideas in pathology. Ductal carcinoma in situ of the breast: a proposal for a new simplified histological classification association between cellular proliferation and c-erbB-2 protein expression.

1994 • 135 citations

A retrospective cohort analysis of second breast cancer risk for primary breast cancer patients with an assessment of the effect of radiation therapy.

1983 • 134 citations

Ductal carcinoma in situ of the breast. Histologic categorization and its relationship to ploidy and immunohistochemical expression of hormone receptors, p53, and c-erbB-2 protein

1995 • 132 citations

Overexpression of the c-erbB-2 oncoprotein: Why does this occur more frequently in ductal carcinoma in situ than in invasive mammary carcinoma and is this of prognostic significance?

1992 • 131 citations

The classification of ductal carcinoma in situ and its association with biological markers.

1994 • 128 citations

Identical allelic loss on chromosome 11q13 in microdissected in situ and invasive human breast cancer.

1995 • 128 citations

Immunohistochemical distribution of c‐erbB‐2 in in situ breast carcinoma—a detailed morphological analysis

1990 • 127 citations

Comparison of Risk Factors for Ductal Carcinoma In Situ and Invasive Breast Cancer

1997 • 127 citations

Incidence of and treatment for ductal carcinoma in situ of the breast

1996 • 124 citations

Immunohistochemical evaluation of c-erbB-2 oncogene expression in ductal carcinoma in situ and atypical ductal hyperplasia of the breast.

1990 • 122 citations

Molecular genetic studies of early breast cancer evolution

1994 • 120 citations

Results of treating ductal carcinomaIn situ of the breast with conservative surgery and radiation therapy

1991 • 114 citations

Loss of heterozygosity in ductal carcinoma in situ of the breast

1995 • 113 citations

Intraductal carcinoma. Analysis of presentation, pathologic findings, and outcome of disease.

1986 • 111 citations

Follow-up of two treatment modalities for ductal cancer in situ of the breast

1989 • 110 citations

Frequency of benign and malignant breast lesions in 207 consecutive autopsies in Australian women

1985 • 109 citations

Oestrogen receptor content of normal breast cells and breast carcinomas throughout the menstrual cycle

1988 • 109 citations

Epidemiology of in situ and invasive breast cancer in women aged under 45

1996 • 106 citations

The Use of Pathologic Features in Selecting the Extent of Surgical Resection Necessary for Breast Cancer Patients Treated by Primary Radiation Therapy

1985 • 105 citations

Age at first primary as a determinant of the incidence of bilateral breast cancer. Cumulative and relative risks in a population-based case-control study

1985 • 104 citations

Mammary duct proliferation in the elderly.A histopathologic study

1973 • 104 citations

Estrogen receptor immunohistoohemistry in carcinoma in situ of the breast

1992 • 104 citations

c-erbB-2 overexpression and histological type of in situ and invasive breast carcinoma.

1992 • 102 citations

Duct carcinoma in situ: predictors of local recurrence and progression in patients treated by surgery alone

1990 • 96 citations

Estimation of currently attainable benefit from mammographic screening of women aged 40-49 years

1995 • 93 citations

Immunohistochemical determination of estrogen and progesterone receptors in human breast carcinoma. Correlation with histopathology and dna flow cytometry

1990 • 88 citations

p53 Mutations and c‐erbB‐2 Amplification in Intraductal and Invasive Breast Carcinomas of High Histologic Grade

1993 • 86 citations

A Markov Chain Method to Estimate the Tumour Progression Rate from Preclinical to Clinical Phase, Sensitivity and Positive Predictive Value for Mammography in Breast Cancer Screening

1996 • 85 citations

Incidence of bilateral tumours in a population-based series of breast-cancer patients. I. Two approaches to an epidemiological analysis

1978 • 83 citations

New swedish breast cancer detection results for women aged 40–49

1993 • 81 citations

Assessment of significance of proportions of intraductal and infiltrating tumor growth in ductal carcinoma of the breast

1973 • 80 citations

Breast conservation therapy for intraductal carcinoma of the breast

1993 • 80 citations

Genomic alterations in human breast carcinomas

1990 • 79 citations

p53 mutations are confined to the comedo type ductal carcinoma in situ of the breast. Immunohistochemical and sequencing data.

1994 • 78 citations

Treatment of intraductal carcinoma with limited surgery: long-term follow-up.

1989 • 76 citations

Intraductal "Noninfiltrating" Carcinoma of the Breast

1976 • 76 citations

The neu-protein and breast cancer

1995 • 74 citations

Allelic loss on a chromosome 17 in ductal carcinoma in situ of the breast.

1993 • 73 citations

Management of screen detected ductal carcinoma in situ of the female breast

1989 • 73 citations

Ductal carcinoma in situ (DCIS): a revised concept.

1987 • 72 citations

Oestrogen receptors in benign epithelial lesions and intraduct carcinomas of the breast: an immunohistological study

1989 • 70 citations

Epidemiology of minimal breast cancer.

1983 • 69 citations

Positive predictive value of breast biopsy performed as a result of mammography: there is no abrupt change at age 50 years.

1996 • 68 citations

Definitive irradiation for intraductal carcinoma of the breast

1990 • 67 citations

Frequent alterations of chromosome 1 in ductal carcinoma in situ of the breast.

1995 • 67 citations

Potential Value of Hormone Receptor Assay in Carcinoma In Situ of Breast

1990 • 65 citations

bcl ‐2 expression in the spectrum of preinvasive breast lesions

1996 • 64 citations

Intraductal carcinoma of the breast.

1984 • 60 citations

A clinicopathologic study of atypical lesions of the breast

1974 • 59 citations

Widespread chromosomal abnormalities in high-grade ductal carcinomain situ of the breast. Comparative genomic hybridization study of pure high-grade DCIS

1999 • 58 citations

Atypical epithelial hyperplasia associated with breast cancer and fibrocystic disease

1969 • 56 citations

Occult breast cancer: prevalence and radiographic detectability.

1987 • 56 citations

bcl-2 expression in the spectrum of preinvasive breast lesions

1996 • 56 citations

The comparative value of mammographic screening for women 40-49 years old versus women 50-64 years old.

1995 • 54 citations

p53 protein expression and nuclear DNA content in breast intraductal proliferations

1995 • 54 citations

The role and prognostic significance of p53 gene alterations in breast cancer

1993 • 53 citations

Immunohistochemical expression of the mutant p53 protein and nuclear DNA content during the transition from benign to malignant breast disease

1994 • 52 citations

Proliferative disorders of the breast as risk factors for breast cancer in a self-selected screened population: pathologic markers.

1980 • 52 citations

Relationship to benign breast disease to carcinoma of the breast.

1962 • 43 citations

p53 alterations in all stages of breast cancer

1991 • 41 citations

Immunohistochemical c-erbB-2 protooncogene expression and nuclear DNA content in human mammary carcinoma in situ.

1992 • 39 citations

Correlations between the mammographic features of ductal carcinoma In situ (DCIS) and C-erbB-2 oncogene expression

1994 • 39 citations

The contralateral breast at reconstructive surgery after breast cancer operation — A histopathological study

1982 • 39 citations

neu overexpression correlates with extent of disease in large cell ductal carcinoma in situ of the breast

1995 • 35 citations

Receptors for estrogen and progesterone in breast carcinoma in situ.

1992 • 35 citations

Preinvasive intraductal carcinoma of the breast.

1960 • 35 citations

Distribution of estrogen receptor in ductal carcinoma in situ of the breast.

1993 • 35 citations

Immunohistochemical study ofneu protein overexpression in clinging in situ duct carcinoma of the breast

1993 • 33 citations

Comparison of the relative incidence of impalpable invasive breast carcinoma and ductal carcinoma in situ in cancers detected in patients older and younger than 50 years of age.

1997 • 32 citations

Age-related differences in patients with nonpalpable breast carcinomas

1996 • 31 citations

NONINVASIVE BREAST CANCER

1994 • 28 citations

Expression of c-erbB-2 in in situ and in Adjacent Invasive Ductal Adenocarcinomas of the Female

1992 • 28 citations

Biophenotypes of Breast Carcinoma in situ Defined by Image Analysis of Biological Parameters

1996 • 28 citations

Breast conserving surgery in the management of in situ breast carcinoma.

1991 • 28 citations

Invasive ductal carcinoma accompanied by ductal carcinoma in situ (DCIS): comparison of DCIS grade with grade of invasive component

1997 • 27 citations

Family history and bilateral primary breast cancer

1985 • 25 citations

Relationship between mammographic screening intervals and size and histology of ductal carcinoma in situ.

1999 • 24 citations

Prognostic Factors of Breast Neoplasms Detected on Screening by Mammography and Physical Examination

1979 • 23 citations

Consensus Conference on the Classification of Ductal Carcinoma of the Breast, April 22–25, 1999

2000 • 23 citations

The p53 tumor-suppressor gene in human breast cancer

1994 • 21 citations

Epidemiology of minimal breast cancer

1983 • 14 citations

Ductal carcinoma in situ of the breast: understanding the misunderstood stepchild

1996 • 6 citations

Pathologic findings from the National Surgical Adjuvant Breast Project (protocol 6). I. Intraductal carcinoma (DCIS)

1986 • 2 citations

Bone mineral density in postmenopausal women with breast cancer and the effect of tamoxifen

1994 • 1 citations

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