Leukocyte-Induced Tissue Injury

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

The Biochemical Basis of Phagocytosis

1959 • 1,240 citations

Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog.

1983 • 1,168 citations

Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.

1978 • 1,117 citations

Free Radicals and Inflammation: Protection of Synovial Fluid by Superoxide Dismutase

1974 • 1,109 citations

Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair

1986 • 933 citations

Oxygen Metabolism and the Toxic Properties of Phagocytes

1980 • 886 citations

Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex

1978 • 876 citations

Superoxide and Superoxide Dismutases

1978 • 754 citations

Tissue injury in inflammation. Oxidants, proteinases, and cationic proteins.

1987 • 699 citations

Leukocyte-endothelial interactions

1985 • 635 citations

Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma.

1980 • 628 citations

The neutrophil: Function and clinical disorders

1979 • 628 citations

Mechanism for irreversible self-deactivation of prostaglandin synthetase.

1976 • 600 citations

Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells.

1981 • 587 citations

Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase.

1986 • 576 citations

Intravascular activation of complement and acute lung injury. Dependency on neutrophils and toxic oxygen metabolites.

1982 • 554 citations

Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity.

1979 • 538 citations

Elastolytic Activity in Pulmonary Lavage Fluid from Patients with Adult Respiratory-Distress Syndrome

1981 • 528 citations

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

1986 • 520 citations

Elastase in Tissue Injury

1985 • 512 citations

Poly(ADP-ribose) synthesis in vitro programmed by damaged DNA. A comparison of DNA molecules containing different types of strand breaks.

1980 • 488 citations

Irreversible reaction of 3-amino-1:2:4-triazole and related inhibitors with the protein of catalase

1960 • 485 citations

Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.

1986 • 466 citations

Neutrophil-mediated endothelial injury in vitro mechanisms of cell detachment.

1981 • 446 citations

Phagocytes as Carcinogens: Malignant Transformation Produced by Human Neutrophils

1985 • 443 citations

Biological reactivity of hypochlorous acid: implications for microbicidal mechanisms of leukocyte myeloperoxidase.

1981 • 443 citations

Prevention by granulocyte depletion of increased vascular permeability of sheep lung following endotoxemia.

1981 • 426 citations

Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide.

1979 • 423 citations

A ROLE OF POLYMORPHONUCLEAR LEUKOCYTES AND COMPLEMENT IN NEPHROTOXIC NEPHRITIS

1965 • 421 citations

Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome. Role of inflammation in the pathogenesis of bronchopulmonary dysplasia.

1983 • 396 citations

The mechanism of NADPH-dependent lipid peroxidation. The propagation of lipid peroxidation.

1979 • 390 citations

Effect of oxygen‐derived free radicals on hyaluronic acid

1980 • 368 citations

In vivo damage of rat lungs by oxygen metabolites.

1981 • 360 citations

Studies on the Pathogenesis of the Adult Respiratory Distress Syndrome

1982 • 359 citations

Pathogenesis of the adult respiratory distress syndrome. Evidence of oxidant activity in bronchoalveolar lavage fluid.

1983 • 340 citations

Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury.

1983 • 338 citations

Prevention of granulocyte-mediated oxidant lung injury in rats by a hydroxyl radical scavenger, dimethylthiourea.

1984 • 322 citations

The Immunologic Release of Constituents from Neutrophil Leukocytes

1971 • 319 citations

Neutrophil-mediated tumor cell cytotoxicity: role of the peroxidase system.

1975 • 317 citations

Effect of N-acetylcysteine on the pulmonary response to endotoxin in the awake sheep and upon in vitro granulocyte function.

1984 • 310 citations

Leukocytes are required for increased lung microvascular permeability after microembolization in sheep.

1981 • 271 citations

Alterations in adenosine triphosphate and energy charge in cultured endothelial and P388D1 cells after oxidant injury.

1985 • 268 citations

POLYMORPHONUCLEAR LEUKOCYTES IN IMMUNOLOGIC REACTIONS

1966 • 266 citations

Hydrogen peroxide causes the fatal injury to human fibroblasts exposed to oxygen radicals.

1981 • 260 citations

Superoxide production by phagocytic leukocytes.

1975 • 257 citations

Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals.

1982 • 257 citations

Myeloperoxidase, hydrogen peroxide, chloride antimicrobial system: nitrogen-chlorine derivatives of bacterial components in bactericidal action against Escherichia coli

1979 • 251 citations

Reduction of myocardial infarct size by neutrophil depletion: Effect of duration of occlusion

1986 • 238 citations

Oxygen-radical-mediated permeability edema and vasoconstriction in isolated perfused rabbit lungs.

1982 • 222 citations

Vascular Injury and Lysis of Basement Membrane in vitro by Neutral Protease of Human Leukocytes

1968 • 211 citations

Cardiac transport of glutathione disulfide and S-conjugate. Studies with isolated perfused rat heart during hydroperoxide metabolism.

1984 • 206 citations

Properties of glutathione release observed during reduction of organic hydroperoxide, demethylation of aminopyrine and oxidation of some substances in perfused rat liver, and their implications for the physiological function of catalase

1977 • 206 citations

PRODUCTION OF INFLAMMATORY CHANGES IN THE MICROCIRCULATION BY CATIONIC PROTEINS EXTRACTED FROM LYSOSOMES

1964 • 198 citations

Polymorphonuclear leukocyte-mediated cell and tissue injury: Oxygen metabolites and their relations to human disease

1985 • 197 citations

Reduction of myocardial ischemic injury with oxygen-derived free radical scavengers.

1983 • 195 citations

Biochemical and Clinical Aspects of Oxygen

1979 • 186 citations

Oxidant injury of lung parenchymal cells.

1981 • 185 citations

Lung injury induced by leukocytic proteases.

1979 • 183 citations

Oxygen Radical Dependent Lung Damage following Thermal Injury of Rat Skin

1983 • 182 citations

PATHOGENIC FACTORS IN VASCULAR LESIONS OF EXPERIMENTAL SERUM SICKNESS

1965 • 172 citations

Glutathione cycle activity and pyridine nucleotide levels in oxidant-induced injury of cells.

1985 • 162 citations

Proteases and oxidants in experimental pulmonary inflammatory injury.

1984 • 158 citations

The role of superoxide in the destruction of erythrocyte targets by human neutrophils.

1980 • 156 citations

Participation of superoxide anions at the prostaglandin phase of carrageenan foot-oedema

1976 • 153 citations

Granulocytes and Phorbol Myristate Acetate Increase Permeability to Albumin of Cultured Endothelial Monolayers and Isolated Perfused Lungs

1983 • 152 citations

Glomerular basement membrane damage in immunological glomerulonephritis.

1968 • 145 citations

The Mechanism of Inactivation of Glyceraldehyde 3-Phosphate Dehydrogenase by Tetrathionate, o-Iodosobenzoate, and Iodine Monochloride

1969 • 135 citations

Myeloperoxidase of Human Neutrophilic Granulocytes as Chlorinating Enzyme

1974 • 132 citations

Intact human erythrocytes prevent hydrogen peroxide-mediated damage to isolated perfused rat lungs and cultured bovine pulmonary artery endothelial cells.

1984 • 132 citations

Role of oxidants in DNA damage. Hydroxyl radical mediates the synergistic DNA damaging effects of asbestos and cigarette smoke.

1987 • 130 citations

A carbon-centered free radical intermediate in the prostaglandin synthetase oxidation of arachidonic acid. Spin trapping and oxygen uptake studies.

1980 • 128 citations

Intracellular calcium homeostasis during hydrogen peroxide injury to cultured P388D₁ cells

1986 • 120 citations

Protein degradation following treatment with hydrogen peroxide.

1984 • 116 citations

Rate of reaction of superoxide radical with chloride-containing species

1980 • 113 citations

Biochemical requirements for singlet oxygen production by purified human myeloperoxidase.

1984 • 113 citations

Inactivation of human α1-proteinase inhibitor by thiol proteinases

1977 • 112 citations

Breakdown of cartilage proteinpolysaccharide by lysosomes

1968 • 108 citations

O2 metabolites and neutrophil elastase synergistically cause edematous injury in isolated rat lungs

1986 • 104 citations

Acute and progressive lung injury after contact with phorbol myristate acetate.

1982 • 99 citations

Enzymatic reduction of oxidized alpha-1-proteinase inhibitor restores biological activity.

1981 • 98 citations

The Role of Lysosomes in Immune Responses

1970 • 98 citations

ISOLATION AND CHARACTERIZATION OF PERMEABILITY FACTORS FROM RABBIT NEUTROPHILS

1968 • 98 citations

MEDIATORS OF INFLAMMATION IN LEUKOCYTE LYSOSOMES

1965 • 95 citations

A potential role for hypochlorous acid in granulocyte-mediated tumor cell cytotoxicity

1980 • 95 citations

Evidence for a role of hydroxyl radical in immune-complex-induced vasculitis.

1984 • 88 citations

Polymorphonuclear leukocyte migration through human amnion membrane

1981 • 83 citations

MEDIATORS OF INFLAMMATION IN LEUKOCYTE LYSOSOMES

1966 • 81 citations

Lymphocyte dysfunction after DNA damage by toxic oxygen species. A model of immunodeficiency.

1986 • 81 citations

The Role of Lysosomes in Hypersensitivity Reactions: Tissue Damage by Polymorphonuclear Neutrophil Lysosomes

1965 • 80 citations

Oxygen radical-induced erythrocyte hemolysis by neutrophils. Critical role of iron and lactoferrin.

1985 • 75 citations

Intravascular release of intact cellular fibronectin during oxidant-induced injury of the in vitro perfused rabbit lung.

1986 • 66 citations

Oxidative Bactericidal Mechanisms of Polymorphonuclear Leukocytes

1975 • 60 citations

Dimethylthiourea consumption reflects H2O2 concentrations and severity of acute lung injury

1985 • 59 citations

Immune-Complex-Mediated Biologic Effects

1981 • 56 citations

Hemolysis and iodination of erythrocyte components by a myeloperoxidase- mediated system

1975 • 51 citations

Biology of disease. Newer concepts in the pathogenesis of immune complex-induced tissue injury.

1982 • 50 citations

Sputum sol-phase proteins and elastase activity in patients with cystic fibrosis.

1984 • 47 citations

DEVELOPMENTS IN BIOCHEMISTRY

1982 • 46 citations

PATHOGENESIS OF INFLAMMATION

1964 • 43 citations

A permeability factor released from phagocytosing PMN-leukocytes and its inhibition by protease inhibitors

1964 • 38 citations

Evidence for the role of superoxide radicals in neutrophil-mediated cytotoxicity.

1979 • 37 citations

Experimental pulmonary inflammatory injury in the monkey.

1985 • 32 citations

Inhibiting Effect of Tobacco Smoke on Some Crystalline Enzymes

1961 • 31 citations

Dimethylthiourea decreases acute lung edema in phorbol myristate acetate-treated rabbits

1986 • 29 citations

Macrophage-mediated cytolysis of erythrocytes in the guinea pig

1981 • 22 citations

Lectin-dependent neutrophil-mediated cytotoxicity against chicken erythrocytes: a model of non-myeloperoxidase-mediated oxygen-dependent killing by human neutrophils.

1980 • 7 citations

Thiourea and dimethylthiourea decrease human neutrophil bactericidal function in vitro

1988 • 6 citations

Arthritis in the rabbit knee joint: a quantitated model.

1975 • 4 citations