Inflammatory mediators in atherosclerotic vascular disease

Inflammation in atherosclerosis

2002 • 7,873 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Interleukin-8 as a Macrophage-Derived Mediator of Angiogenesis

1992 • 2,130 citations

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

1998 • 2,047 citations

A new class of membrane-bound chemokine with a CX3C motif

1997 • 1,964 citations

Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis

1998 • 1,943 citations

Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4

1999 • 1,714 citations

Absence of Monocyte Chemoattractant Protein-1 Reduces Atherosclerosis in Low Density Lipoprotein Receptor–Deficient Mice

1998 • 1,569 citations

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

1998 • 1,535 citations

MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions

1999 • 1,228 citations

Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis

2002 • 1,170 citations

Innate and Adaptive Immunity in the Pathogenesis of Atherosclerosis

2002 • 1,027 citations

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E

2002 • 989 citations

Reduction of atherosclerosis in mice by inhibition of CD40 signalling

1998 • 917 citations

Monocyte chemoattractant protein-1 in human atheromatous plaques.

1991 • 892 citations

Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions.

1991 • 879 citations

IFN-gamma potentiates atherosclerosis in ApoE knock-out mice.

1997 • 855 citations

Immune Mechanisms in Atherosclerosis

2001 • 852 citations

Immune mechanisms in atherosclerosis.

1989 • 827 citations

Protective Role of Interleukin-10 in Atherosclerosis

1999 • 805 citations

Current understanding of stem cell mobilization

2002 • 801 citations

Novel Clinical Markers of Vascular Wall Inflammation

2001 • 750 citations

Atherogenesis in perspective: Hypercholesterolemia and inflammation as partners in crime

2002 • 680 citations

Fractalkine and CX3CR1 Mediate a Novel Mechanism of Leukocyte Capture, Firm Adhesion, and Activation under Physiologic Flow

1998 • 679 citations

Tumor Necrosis Factor-α-converting Enzyme (ADAM17) Mediates the Cleavage and Shedding of Fractalkine (CX3CL1)

2001 • 623 citations

Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function

2000 • 606 citations

The CXC Chemokine Receptor 2, CXCR2, Is the Putative Receptor for ELR+ CXC Chemokine-Induced Angiogenic Activity

2000 • 565 citations

Glycosaminoglycans Interact Selectively with Chemokines and Modulate Receptor Binding and Cellular Responses

1999 • 564 citations

RANTES Deposition by Platelets Triggers Monocyte Arrest on Inflamed and Atherosclerotic Endothelium

2001 • 561 citations

A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice.

1998 • 525 citations

Chemokines and atherosclerosis

1999 • 510 citations

Smooth Muscle Progenitor Cells in Human Blood

2002 • 504 citations

Inhibition of Tumor Necrosis Factor-α Reduces Atherosclerosis in Apolipoprotein E Knockout Mice

2004 • 476 citations

Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells

1999 • 475 citations

Decreased Atherosclerotic Lesion Formation in CX3CR1/Apolipoprotein E Double Knockout Mice

2003 • 465 citations

Decreased atherosclerosis in CX3CR1–/– mice reveals a role for fractalkine in atherogenesis

2003 • 460 citations

Requirement for CD154 in the progression of atherosclerosis

1999 • 437 citations

Disruption of TGF-β signaling in T cells accelerates atherosclerosis

2003 • 426 citations

Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines

2001 • 398 citations

Interferon-γ elicits arteriosclerosis in the absence of leukocytes

2000 • 375 citations

Antagonism of RANTES Receptors Reduces Atherosclerotic Plaque Formation in Mice

2003 • 366 citations

Deposition of Platelet RANTES Triggering Monocyte Recruitment Requires P-Selectin and Is Involved in Neointima Formation After Arterial Injury

2002 • 345 citations

Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient mice

1999 • 340 citations

The Stromal Cell–Derived Factor-1 Chemokine Is a Potent Platelet Agonist Highly Expressed in Atherosclerotic Plaques

2000 • 315 citations

Changes in the endothelium of the aorta and the behaviour of macrophages in experimental atheroma of rabbits

1958 • 270 citations

The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium

2001 • 263 citations

Expression of Macrophage Migration Inhibitory Factor in Different Stages of Human Atherosclerosis

2002 • 253 citations

Specialized roles of the chemokine receptors CCR1 and CCR5 in the recruitment of monocytes and TH1-like/CD45RO+T cells

2001 • 253 citations

Interleukin 8 Is Induced by Cholesterol Loading of Macrophages and Expressed by Macrophage Foam Cells in Human Atheroma

1996 • 251 citations

New Anti–Monocyte Chemoattractant Protein-1 Gene Therapy Attenuates Atherosclerosis in Apolipoprotein E–Knockout Mice

2001 • 244 citations

Chemokines

2004 • 244 citations

Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets

2000 • 243 citations

Overexpression of Eotaxin and the CCR3 Receptor in Human Atherosclerosis

2000 • 243 citations

Mapping of vascular dendritic cells in atherosclerotic arteries suggests their involvement in local immune-inflammatory reactions

1998 • 238 citations

The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig

1998 • 235 citations

Anti–Monocyte Chemoattractant Protein-1/Monocyte Chemotactic and Activating Factor Antibody Inhibits Neointimal Hyperplasia in Injured Rat Carotid Arteries

1999 • 230 citations

Circulating Bone Marrow Cells Can Contribute to Neointimal Formation

2001 • 225 citations

Elevated expression of monocyte chemoattractant protein 1 by vascular smooth muscle cells in hypercholesterolemic primates.

1992 • 223 citations

Monoclonal antibodies detect different distribution patterns of IL-8 receptor A and IL-8 receptor B on human peripheral blood leukocytes.

1994 • 222 citations

Tumor Necrosis Factor-α-converting Enzyme Mediates the Inducible Cleavage of Fractalkine

2001 • 221 citations

Differential Effects of Interleukin-1 Receptor Antagonist and Tumor Necrosis Factor Binding Protein on Fatty-Streak Formation in Apolipoprotein E–Deficient Mice

1998 • 209 citations

Differential immobilization and hierarchical involvement of chemokines in monocyte arrest and transmigration on inflamed endothelium in shear flow

1999 • 202 citations

Crucial Role of Stromal Cell–Derived Factor-1α in Neointima Formation After Vascular Injury in Apolipoprotein E–Deficient Mice

2003 • 202 citations

CXCL16/SR-PSOX Is an Interferon-γ–Regulated Chemokine and Scavenger Receptor Expressed in Atherosclerotic Lesions

2004 • 193 citations

Accelerated Atherosclerosis in Mice Lacking Tumor Necrosis Factor Receptor p55

1996 • 183 citations

Linked Chromosome 16q13 Chemokines, Macrophage-Derived Chemokine, Fractalkine, and Thymus- and Activation-Regulated Chemokine, Are Expressed in Human Atherosclerotic Lesions

2001 • 182 citations

Local Expression of Inflammatory Cytokines in Human Atherosclerotic Plaques

1994 • 178 citations

Novel mechanistic concepts for the control of leukocyte transmigration: specialization of integrins, chemokines, and junctional molecules

2003 • 176 citations

Expression of SR-PSOX, a Novel Cell-Surface Scavenger Receptor for Phosphatidylserine and Oxidized LDL in Human Atherosclerotic Lesions

2001 • 176 citations

Chemokine Receptor CCR2 Expression and Monocyte Chemoattractant Protein-1–Mediated Chemotaxis in Human Monocytes

1998 • 176 citations

Macrophage Migration Inhibitory Factor Deficiency Impairs Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

2004 • 169 citations

CCR5 deficiency is not protective in the early stages of atherogenesis in apoE knockout mice

2003 • 168 citations

Stabilization of Atherosclerotic Plaques by Blockade of Macrophage Migration Inhibitory Factor After Vascular Injury in Apolipoprotein E–Deficient Mice

2003 • 164 citations

Importance of Monocyte Chemoattractant Protein-1 Pathway in Neointimal Hyperplasia After Periarterial Injury in Mice and Monkeys

2002 • 162 citations

Smooth Muscle Cells in Human Atherosclerotic Plaques Express the Fractalkine Receptor CX ₃ CR1 and Undergo Chemotaxis to the CX ₃ C Chemokine Fractalkine (CX ₃ CL1)

2003 • 151 citations

JE mRNA accumulates rapidly in aortic injury and in platelet-derived growth factor-stimulated vascular smooth muscle cells.

1992 • 147 citations

Stromal Cell–Derived Factor-1α in Unstable Angina

2002 • 141 citations

Local Overexpression of Monocyte Chemoattractant Protein-1 at Vessel Wall Induces Infiltration of Macrophages and Formation of Atherosclerotic Lesion

2002 • 141 citations

Loss of Lymphotoxin-α but Not Tumor Necrosis Factor-α Reduces Atherosclerosis in Mice

2002 • 140 citations

Crucial Role of the CCL2/CCR2 Axis in Neointimal Hyperplasia After Arterial Injury in Hyperlipidemic Mice Involves Early Monocyte Recruitment and CCL2 Presentation on Platelets

2004 • 136 citations

Expression of transcripts for two interleukin 8 receptors in human phagocytes, lymphocytes and melanoma cells

1993 • 132 citations

Novel role of the membrane-bound chemokine fractalkine in platelet activation and adhesion

2003 • 132 citations

Essential Role of Monocyte Chemoattractant Protein-1 in Development of Restenotic Changes (Neointimal Hyperplasia and Constrictive Remodeling) After Balloon Angioplasty in Hypercholesterolemic Rabbits

2002 • 131 citations

Targeting CCR2 or CD18 Inhibits Experimental In-Stent Restenosis in Primates

2002 • 127 citations

De Novo Expression of Macrophage Migration Inhibitory Factor in Atherogenesis in Rabbits

2000 • 127 citations

CCR2 Deficiency Decreases Intimal Hyperplasia After Arterial Injury

2002 • 126 citations

Chemokines and atherosclerosis

2004 • 122 citations

Expression and Cellular Localization of the CC Chemokines PARC and ELC in Human Atherosclerotic Plaques

1999 • 121 citations

Role of the GRO family of chemokines in monocyte adhesion to MM-LDL-stimulated endothelium.

1994 • 117 citations

Differential Expression Patterns of Proinflammatory and Antiinflammatory Mediators During Atherogenesis in Mice

2004 • 89 citations

CC Chemokine I-309 Is the Principal Monocyte Chemoattractant Induced by Apolipoprotein(a) in Human Vascular Endothelial Cells

2000 • 89 citations

Blockade of Keratinocyte-Derived Chemokine Inhibits Endothelial Recovery and Enhances Plaque Formation After Arterial Injury in ApoE-Deficient Mice

2004 • 85 citations

Human platelet surface binding of endogenous secreted factor VIII-von Willebrand factor and platelet factor 4

1982 • 83 citations

Evidence for a Role of Macrophage Migration Inhibitory Factor in Vascular Disease

2004 • 82 citations

Combinatorial Model of Chemokine Involvement in Glomerular Monocyte Recruitment: Role of CXC Chemokine Receptor 2 in Infiltration During Nephrotoxic Nephritis

2001 • 74 citations

Transplantation of Monocyte CC-Chemokine Receptor 2–Deficient Bone Marrow Into ApoE3–Leiden Mice Inhibits Atherogenesis

2003 • 71 citations

Monocyte and Neutrophil Adhesion to Matrix Proteins is Selectively Enhanced in the Presence of Inflammatory Mediators

1996 • 27 citations

P1761 Crucial role for both chemokines receptors CCR2 and CXCR3 in atherogenesis

2003 • 3 citations