The role of steroid contraceptive hormones in the pathogenesis of invasive cervical cancer: A review

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective

1995 • 3,371 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Estimates of the worldwide incidence of eighteen major cancers in 1985

1993 • 1,680 citations

Functional domains of the human estrogen receptor

1987 • 1,316 citations

The Pezcoller lecture: cancer cell cycles revisited.

2000 • 1,208 citations

Role of a p53 polymorphism in the development of human papilloma-virus-associated cancer

1998 • 976 citations

Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.

1993 • 526 citations

The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

2000 • 483 citations

A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression.

1987 • 360 citations

The Human Papillomavirus Type 16 E6 Oncoprotein Can Down-Regulate p53 Activity by Targeting the Transcriptional Coactivator CBP/p300

1999 • 325 citations

Characterization of the human p53 gene.

1986 • 321 citations

Medicine and the Law

1966 • 308 citations

Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice.

1996 • 293 citations

ORAL CONTRACEPTIVE USE AND MALIGNANCIES OF THE GENITAL TRACT

1988 • 292 citations

The estrogen-responsive element as an inducible enhancer: DNA sequence requirements and conversion to a glucocorticoid-responsive element.

1987 • 268 citations

Characteristics of women with dysplasia or carcinoma in situ of the cervix uteri

1980 • 267 citations

Transcriptional regulation by steroid hormones

1996 • 256 citations

Mortality associated with oral contraceptive use: 25 year follow up of cohort of 46 000 women from Royal College of General Practitioners' oral contraception study

1999 • 246 citations

Sexual and Reproductive Risk Factors for Invasive Squamous Cell Cervical Cancer

1987 • 207 citations

PARITY AS A RISK FACTOR FOR CERVICAL CANCER

1989 • 197 citations

Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes

1992 • 177 citations

Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.

1985 • 174 citations

Oestrogen Stimulates Differential Transcription of Human Papillomavirus Type 16 in SiHa Cervical Carcinoma Cells

1989 • 132 citations

Influence of chromosomal integration on glucocorticoid-regulated transcription of growth-stimulating papillomavirus genes E6 and E7 in cervical carcinoma cells.

1991 • 127 citations

Human papillomavirus type 16 cooperates with activated ras and fos oncogenes in the hormone-dependent transformation of primary mouse cells.

1988 • 118 citations

Steroid Contraceptive Use and Cervical Dysplasia: Increased Risk of Progression

1977 • 103 citations

Human papillomavirus and long-term oral contraceptive use increase the risk of adenocarcinoma in situ of the cervix.

2001 • 100 citations

Cervical dysplasia: Association with sexual behavior, smoking, and oral contraceptive use?

1985 • 96 citations

Mutations of p53 and human papillomavirus infection in cervical carcinoma

1993 • 91 citations

Invasive cervical cancer and combined oral contraceptives. WHO collaborative study of neoplasia and steroid contraceptives.

1985 • 83 citations

Estrogen and progesterone receptors in cervical human papillomavirus related lesions

1991 • 81 citations

Association of oral contraceptive use and human papillomaviruses in invasive cervical cancers

1990 • 74 citations

The disruption of cell cycle checkpoints by papillomavirus oncoproteins contributes to anogenital neoplasia

1996 • 72 citations

Immunohistochemical detection of sex steroid receptors, cyclins, and cyclin-dependent kinases in the normal and neoplastic squamous epithelia of the uterine cervix

1998 • 66 citations

Invasive squamous‐cell cervical carcinoma and combined oral contraceptives: Results from a multinational study

1993 • 62 citations

Relationship of oral contraceptives to cervical carcinogenesis.

1972 • 62 citations

Cancer of the Cervix of the Uterus in Hybrid Mice Following Long-Continued Administration of Estrogen

1941 • 61 citations

Oral contraceptives and cervical carcinoma

1977 • 57 citations

A REVIEW OF PROBLEMS OF BIAS AND CONFOUNDING IN EPIDEMIOLOGIC STUDIES OF CERVICAL NEOPLASIA AND ORAL CONTRACEPTIVE USE

1982 • 56 citations

Molecular events in uterine cervical cancer

1998 • 55 citations

A CASE CONTROL STUDY INTO THE POSSIBLE EFFECTS OF BIRTH CONTROL PILLS ON PRE‐CLINICAL CARCINOMA OF THE CERVIX

1972 • 55 citations

Altered Growth and Viral Gene Expression in Human Papillomavirus Type 16-Containing Cancer Cell Lines Treated with Progesterone

1999 • 48 citations

Use of oral contraceptives and risk of invasive cervical cancer in previously screened women

1987 • 47 citations

Early incidence rates of precancerous cervical lesions in women using contraceptives

1973 • 38 citations

A case-control study of cervix cancer in Singapore

1989 • 35 citations

Oral contraceptives and cervical cancer

1985 • 35 citations

Long-term use of oral contraceptives and cervical neoplasia: An association confounded by other risk factors?

1985 • 31 citations

True

2000 • 29 citations

Cervical carcinoma and oral contraception.

1972 • 29 citations

Abnormal expression and mutation of p53 in cervical cancer--a study at protein, RNA and DNA levels.

1997 • 27 citations

Cigarette smoking and invasive cervical cancer

1986 • 24 citations

Carcinoma-Like Proliferations in Vagina, Cervix, and Uterus of Mouse Treated with Estrogenic Hormones.

1936 • 22 citations

Carcinoma of the cervix in oral contraceptive steroid and IUD users and nonusers

1976 • 21 citations

RU486 inhibits glucocorticoid hormone-dependent oncogenesis by human papillomavirus type 16 DNA

1991 • 19 citations

Up-regulation of hormone response of human papillomavirus type 16 expression and increased DNA-protein binding by consensus mutations of viral glucocorticoid response elements

1996 • 10 citations

Comparative in vitro study of nonoxynol-9: Effects on human, bull and boar spermatozoa

1992 • 9 citations

HIV and cancer in South Africa.

1993 • 6 citations

Contraceptive choice and dysplasia: Changes following the 1970 senate hearings

1973 • 4 citations

Dexamethasone-Enhanced Cisplatin Resistance of Human Lung Carcinoma Cells

1995 • 2 citations

Players in policy

1987 • 2 citations