The Role of Organic Osmolytes in the Regulation of Mammalian Cell Volume

Living with Water Stress: Evolution of Osmolyte Systems

1982 • 3,735 citations

Biochemistry and physiology of taurine and taurine derivatives.

1968 • 1,038 citations

Sorbitol, Phosphoinositides, and Sodium-Potassium-ATPase in the Pathogenesis of Diabetic Complications

1987 • 905 citations

Membrane mechanisms in volume and pH regulation in vertebrate cells

1989 • 880 citations

Osmotic Demyelination Syndrome Following Correction of Hyponatremia

1986 • 757 citations

Regulation of cellular volume.

1977 • 607 citations

TAURINE: BIOLOGICAL UPDATE

1986 • 571 citations

Physiology and Biophysics.

1966 • 550 citations

Transport of α-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes

1983 • 510 citations

Transport of ions and water in animals

1977 • 481 citations

Counteraction of urea destabilization of protein structure by methylamine osmoregulatory compounds of elasmobranch fishes

1979 • 386 citations

Predominant osmotically active organic solutes in rat and rabbit renal medullas.

1986 • 382 citations

Physiology and Biophysics

1966 • 379 citations

Protons, osmolytes, and fitness of internal milieu for protein function

1986 • 340 citations

Effects on the central nervous system of hypernatremic and hyponatremic states

1976 • 320 citations

Metabolism and Function of myo-Inositol and Inositol Phospholipids

1986 • 298 citations

Mechanisms of osmoregulation in animals

1979 • 290 citations

Taurine Biological Actions and Clinical Perspectives

1986 • 277 citations

The renal handling of amino acids and oligopeptides.

1988 • 274 citations

AMINO ACIDS AS CENTRAL NERVOUS TRANSMITTERS: THE INFLUENCE OF IONS, AMINO ACID ANALOGUES, AND ONTOGENY ON TRANSPORT SYSTEMS for <scp>l</scp>‐GLUTAMIC AND <scp>l</scp>‐ASPARTIC ACIDS AND GLYCINE INTO CENTRAL NERVOUS SYNAPTOSOMES OF THE RAT¹

1973 • 261 citations

Volume regulation in astrocytes: A role for taurine as an osmoeffector

1988 • 260 citations

d-Myoinositol 1-Phosphate as Product of Cyclization of Glucose 6-Phosphate and Substrate for a Specific Phosphatase in Rat Testis

1967 • 252 citations

Taurine: An Essential Nutrient for the Cat

1978 • 250 citations

Separation of active and passive components of short-range stiffness of muscle

1977 • 247 citations

Untersuchungen zum Problem der Harnkonzentrierung und Harnverd�nnung

1956 • 246 citations

Methylamine osmoregulatory solutes of elasmobranch fishes counteract urea inhibition of enzymes

1980 • 245 citations

Brain water and electrolyte metabolism in uremia: Effects of slow and rapid hemodialysis

1973 • 232 citations

K+, Na+, and Cl- activities in ventricular myocytes isolated from rabbit heart

1986 • 229 citations

A Possible Role for Taurine in Osmoregulation Within the Brain

1988 • 223 citations

Taurine: A role in osmotic regulation of mammalian brain and possible clinical significance

1980 • 205 citations

Transport Processes, Iono- and Osmoregulation

1985 • 199 citations

Urinary Concentrating Mechanism. Structure and Function.

1982 • 189 citations

Permeability of blood-brain barrier to various sized molecules

1985 • 188 citations

Subcellular distribution of taurine and cysteinesulphinate decarboxylase in developing rat brain

1971 • 179 citations

Induction of aldose reductase and sorbitol in renal inner medullary cells by elevated extracellular NaCl.

1987 • 173 citations

Brain dehydration and neurologic deterioration after rapid correction of hyponatremia

1989 • 172 citations

Adaptation to chronic hypoosmolality in rats

1988 • 169 citations

Molecular cloning of cDNA coding for kidney aldose reductase

1989 • 149 citations

Immunohistochemical Localization of Aldose Reductase: II. Rat Eye and Kidney

1980 • 148 citations

Abnormalities of cell volume regulation and their functional consequences

1980 • 145 citations

L'aldose-réductase

1960 • 144 citations

PLASMA OSMOLALITY AND URINARY CONCENTRATION AND DILUTION DURING AND AFTER PREGNANCY: EVIDENCE THAT LATERAL RECUMBENCY INHIBITS MAXIMAL URINARY CONCENTRATING ABILITY

1981 • 138 citations

Characterization of the major brain osmolytes that accumulate in salt-loaded rats

1989 • 138 citations

Release of taurine from astrocytes during potassium‐evoked swelling

1989 • 134 citations

Osmoregulatory changes in myo-inositol transport by renal cells.

1989 • 132 citations

Taurine and Osmoregulation: Taurine Is a Cerebral Osmoprotective Molecule in Chronic Hypernatremic Dehydration

1988 • 128 citations

Hypernatremic (Hypertonic) Dehydration in Infants

1973 • 127 citations

Amino acid transport and cell volume regulation in Ehrlich ascites tumour cells.

1983 • 125 citations

Isovolumetric regulation of isolated S2 proximal tubules in anisotonic media.

1986 • 125 citations

myo-Inositol: A Newly Identified Nonnitrogenous Osmoregulatory Molecule in Mammalian Brain

1989 • 120 citations

Survey of osmolytes in renal cell lines

1988 • 119 citations

Proline porters effect the utilization of proline as nutrient or osmoprotectant for bacteria

1988 • 115 citations

Intra- and extracellular element concentrations of rat renal papilla in antidiuresis

1984 • 113 citations

An intercellular substance in rat cerebral cortex: Submicroscopic distribution of ruthenium red

1967 • 112 citations

Osmotic Volumes of Distribution

1955 • 111 citations

Urea transport in the central nervous system

1962 • 109 citations

ENCEPHALOPATHY AND MYELINOLYSIS AFTER RAPID CORRECTION OF HYPONATRAEMIA

1987 • 106 citations

[Studies on the problem of urine concentration and dilution; distribution of electrolytes (sodium, potassium, calcium, magnesium, anorganic phosphate), urea amino acids and exogenous creatinine in the cortex and medulla of dog kidney in various diuretic conditions].

1956 • 106 citations

Mutual Inhibition Kinetic Analysis of γ‐Aminobutyric Acid, Taurine, and β‐Alanine High‐Affinity Transport into Neurons and Astrocytes: Evidence for Similarity Between the Taurine and β‐Alanine Carriers in Both Cell Types

1986 • 106 citations

The tissue activities of some diagnostic enzymes in ten mammalian species

1978 • 105 citations

Counteracting effects of urea and betaine in mammalian cells in culture

1990 • 104 citations

Osmoregulation of betaine transport in mammalian renal medullary cells

1990 • 104 citations

Volume Regulation in Cultured Cells

1987 • 104 citations

The distribution of free mesoinositol in mammalian tissues, including some observations on the lactating rat

1961 • 103 citations

Electron microprobe analysis of intracellular elements in the rat kidney

1980 • 102 citations

Taurine: Possible Role in Osmotic Regulation of Mammalian Heart

1981 • 102 citations

Taurine uptake in astrocytes cultured from dissociated mouse brain hemispheres

1976 • 100 citations

Myoinositol Metabolism in Diabetes Mellitus: Effect of Insulin Treatment

1977 • 99 citations

Disturbances in Body Fluid Osmolality

1977 • 99 citations

Effect of anisotonic media on volume, ion and amino-acid content and membrane potential of kidney cells (MDCK) in culture

1987 • 98 citations

Osmoregulation by slow changes in aldose reductase and rapid changes in sorbitol flux

1988 • 98 citations

Phosphatidylinositol as the endogenous activator of the (Na+ + K+)-ATPase in microsomes of rabbit kidney

1978 • 98 citations

Regulation of brain water and electrolytes during acute hyperosmolality in rats

1987 • 96 citations

Distribution of major organic osmolytes in rabbit kidneys in diuresis and antidiuresis

1989 • 93 citations

Brain Potassium Exchange in Normal Adult and Immature Rats

1953 • 93 citations

The role of amino acids and taurine in isosmotic intracellular regulation in Ehrlich ascites mouse tumour cells

1976 • 91 citations

Interdependence of urea and electrolytes in production of a concentrated urine

1961 • 91 citations

The role of glycerylphosphorylcholine and glycerylphosphorylethanolamine in liver phospholipid metabolism

1955 • 88 citations

Reversible sodium pump defect and swelling in the diabetic rat erythrocyte: effects on filterability and implications for microangiopathy.

1989 • 87 citations

Isolation of glycine betaine and proline betaine from human urine. Assessment of their role as osmoprotective agents for bacteria and the kidney.

1987 • 87 citations

Nitrogen-14 nuclear magnetic resonance spectroscopy of mammalian tissues

1983 • 86 citations

The oxidation of choline by rat liver

1937 • 84 citations

Adaptive decreases in amino acids (taurine in particular), creatine, and electrolytes prevent cerebral edema in chronically hyponatremic mice: Rapid correction (experimental model of central pontine myelinolysis) causes dehydration and shrinkage of brain

1987 • 82 citations

Dose‐Dependent, K⁺‐Stimulated Efflux of Endogenous Taurine from Primary Astrocyte Cultures Is Ca²⁺‐Dependent

1988 • 81 citations

Distribution and metabolism of intravenously administered choline[methyl- 3-H] and synthesis in vivo of acetylcholine in various tissues of guinea pigs.

1975 • 81 citations

Metabolism of myo-inositol in animals

1967 • 80 citations

Elevation of rat brain amino acids, ammonia and idiogenic osmoles induced by hyperosmolality

1979 • 80 citations

Disturbances in body fluid osmolality

1977 • 78 citations

INHIBITION OF AMINO ACID UPTAKE BY THE ABSENCE OF Na+ IN SLICES OF BRAIN

1975 • 78 citations

The Osmoprotective Properties of Urine for Bacteria: The Protective Effect of Betaine and Human Urine Against Low pH and High Concentrations of Electrolytes, Sugars, and Urea

1985 • 78 citations

Ischemic renal injury.

1976 • 77 citations

Osmotic regulation of aldose reductase protein synthesis in renal medullary cells

1989 • 77 citations

Characterization and purification of a mammalian osmoregulatory protein, aldose reductase, induced in renal medullary cells by high extracellular NaCl.

1987 • 77 citations

Sodium-coupled glycine uptake by Ehrlich ascites tumor cells results in an increase in cell volume and plasma membrane channel activities.

1988 • 75 citations

Acidic polysaccharides in the central nervous system

1962 • 75 citations

Effects of NaCl, glucose, and aldose reductase inhibitors on cloning efficiency of renal medullary cells

1990 • 75 citations

Osmotic effectors in kidneys of xeric and mesic rodents: corticomedullary distributions and changes with water availability

1988 • 73 citations

Effects of Sodium Chloride Concentration on Growth, Biochemical Composition, and Metabolism of HeLa Cells

1960 • 71 citations

Effect of acute and chronic hypernatremia on myoinositol and sorbitol concentration in rat brain and kidney

1988 • 69 citations

Evidence for a single common Na+-dependent transport system for alanine, glutamine, leucine and phenylalanine in brush-border membrane vesicles from bovine kidney

1987 • 68 citations

Evaluation of the osmoregulatory function of taurine in brain cells

1987 • 67 citations

Regulation of organic osmolyte concentrations in tubules from rat renal inner medulla

1989 • 67 citations

Renal inner medullary choline dehydrogenase activity: characterization and modulation

1989 • 59 citations

Cell Volume Regulation in the Nervous System

1988 • 58 citations

THE AMINOACIDURIA OF PREGNANCY

1972 • 58 citations

Choline and betaine aldehyde oxidation by rat liver mitochondria

1970 • 58 citations

Rat kidney glycerylphosphorylcholine diesterase

1968 • 57 citations

Peptide and Amino Acid Transport Mechanisms in the Central Nervous System

1988 • 57 citations

Osmoregulation of renal papillary cells

1985 • 56 citations

Sodium ion movements and the spontaneous and electrically stimulated release of [3H]GABA and [14C]glutamic acid from rat cortical slices

1972 • 56 citations

High NaCl induces stable changes in phenotype and karyotype of renal cells in culture

1987 • 55 citations

Developmental and Physiological Regulation of Aldose Reductase mRNA Expression in Renal Medulla

1989 • 54 citations

myo-Inositol transport in renal brush border vesicles and it inhibition by D-glucose

1980 • 54 citations

EFFECTS OF SALT AND WATER LOADING ON CARBOHYDRATE AND ENERGY METABOLISM AND LEVELS OF SELECTED AMINO ACIDS IN THE BRAINS OF YOUNG MICE¹

1975 • 53 citations

Anion dependence of taurine transport by rat renal brush-border membrane vesicles

1989 • 53 citations

Factors affecting the ratio of different organic osmolytes in renal medullary cells

1990 • 52 citations

Intracellular sorbitol content in isolated rat inner medullary collecting duct cells

1989 • 52 citations

Extracellular distribution of ruthenium red-positive substance in the cerebral cortex

1971 • 52 citations

Role and regulation of glycerophosphorylcholine in rat renal papilla

1987 • 52 citations

Adenosine receptor-mediated calcium mobilization in cortical collecting tubule cells

1988 • 52 citations

Osmoregulation of glycerophosphorylcholine content of mammalian renal cells

1989 • 51 citations

Osmoregulatory fluxes of myo-inositol and betaine in renal cells

1989 • 51 citations

�ber das Vorkommen von Phosphorverbindungen in verschiedenen Nierenabschnitten und �nderungen ihrer Konzentration in Abh�ngigkeit vom Diuresezustand

1956 • 50 citations

Acute and Chronic Hyperosmolality

1975 • 50 citations

p-aminohippurate transport in the airways: role of Na+ and HCO3-

1989 • 47 citations

Organic Osmotic Effectors in Cartilaginous Fishes

1985 • 47 citations

Techniques and applications of extracellular space determination in mammalian tissues

1982 • 46 citations

Mechanisms in Volume Regulation in Ehrlich Ascites Tumor Cells

1988 • 46 citations

A novel sorbitol transport mechanism in cultured renal papillary epithelial cells

1989 • 46 citations

Assembly of the endoplasmic reticulum phospholipid bilayer. Transporters for phosphatidylcholine and metabolites.

1987 • 44 citations

Taurine transport by rabbit kidney brush-border membranes: Coupling to sodium, chloride, and the membrane potential

1988 • 44 citations

Enzymatic determination of betaine in rat tissues

1981 • 43 citations

Release of Endogenous Taurine and γ‐Aminobutyric Acid from Brain Slices from the Adult and Developing Mouse

1989 • 41 citations

METABOLIC CHANGES ASSOCIATED WITH ISO‐OSMOTIC REGULATION IN BRAIN CORTEX SLICES

1977 • 41 citations

Aldose reductase activities in microdissected rat renal tubule segments

1989 • 41 citations

CHARACTERIZATION OF TAURINE UPTAKE BY NEURONAL AND GLIAL CELLS IN CULTURE

1979 • 40 citations

PROLINE BETAINE: A UNIQUE OSMOLYTE IN AN EXTREMELY EURYHALINE OSMOCONFORMER

1984 • 40 citations

High-affinity uptake of taurine and ?-alanine in primary cultures of rat astrocytes

1986 • 39 citations

Effect of Chronic Hypernatremic Dehydration and Rapid Rehydration on Brain Carbohydrate, Energy, and Amino Acid Metabolism in Weanling Mice

1983 • 37 citations

In vitro osmoregulation of taurine in fetal mouse hearts*

1984 • 36 citations

Are ninhydrin‐positive substances volume‐regulatory osmolytes in rat renal papillary cells?

1987 • 36 citations

Effects of glycerol infusions on brain water and electrolytes

1974 • 34 citations

Effects of Pregnancy on the Contents of Water, Taurine, and Total Amino Nitrogen in Rat Cerebral Cortex

1989 • 34 citations

Renal Sorbitol Accumulation and Associated Enzyme Activities in Diabetes

1988 • 33 citations

Rapid Correction of Hyponatraemia with Urea may Protect against Brain Damage in Rats

1989 • 32 citations

Activation of γ‐glutamyl transpeptidase by monovalent cations

1973 • 30 citations

Osmoprotective activity for Escherichia coli in mammalian renal inner medulla and urine. Correlation of glycine and proline betaines and sorbitol with response to osmotic loads.

1987 • 29 citations

Effects of inorganic salts and of ouabain on some metabolic responses of rat cerebral cortex slices to cationic and electrical stimulations

1968 • 29 citations

Reversible sodium pump defect and swelling in the diabetic rat erythrocyte : effects on filterability and implications for microangiopathy

1989 • 29 citations

Serial cultivation of ehrlich ascites tumor cells in hypertonic media

1972 • 28 citations

NMR studies of renal phosphate metabolites in vivo: effects of hydration and dehydration

1988 • 28 citations

Neutral Amino Acid Transport in Astrocytes: Characterization of Na⁺‐Dependent and Na⁺‐Independent Components of α‐Aminoisobutyric Acid Uptake

1988 • 28 citations

Free myo-Inositol in Canine Kidneys: Selective Concentration in the Renal Medulla

1982 • 28 citations

Characteristics of Sorbitol Uptake in Rat Glial Primary Cultures

1989 • 27 citations

ON THE UPTAKE OF INOSITOL BY RAT BRAIN SYNAPTOSOMES

1978 • 27 citations

Simultaneous comparison of techniques for x-ray analysis of proximal tubule cells

1986 • 27 citations

Cellular Osmoregulation in Renal Medulla

1988 • 26 citations

Differential effects of hypertonic mannitol and glycerol on rat brain metabolism and amino acids

1981 • 25 citations

Acute regulation of the predominant organic solutes of the rabbit renal inner medulla

1989 • 24 citations

Chloride dependence of the sodium-dependent glycine transport in pig kidney cortex brush-border membrane vesicles

1987 • 23 citations

Cell growth and division in hypertonic medium

1974 • 22 citations

Renal transport of neutral amino acids. Cation-dependent uptake of <scp>l</scp>-alanine by luminal-membrane vesicles

1987 • 22 citations

Composition of renal medullary tissue

1987 • 22 citations

The osmoregulatory function of taurine and glutamic acid.

1985 • 22 citations

Solute transport and epithelial cell volume regulation

1988 • 21 citations

Measurement of Intracellular Ionic Composition and Activities in Renal Tubules

1983 • 21 citations

Quantitative proton magnetic resonance of plasma from uraemic patients during dialysis

1987 • 21 citations

Metabolism of myo-inositol in animals

1967 • 21 citations

Effect of metabolic inhibitors on renal tubule cell volume

1980 • 21 citations

Sorbitol metabolism in inner medullary collecting duct cells of diabetic rats

1989 • 21 citations

Effect of ouabain and colloid osmotic pressure on renal tubule cell volume

1978 • 20 citations

The volume and ionic composition of cells in incubated slices of rat renal cortex, medulla and papilla

1987 • 20 citations

Effects of 0·9% saline infusion on urinary and renal tissue composition in the hydropaenic, normal and hydrated conscious rat

1970 • 20 citations

Effect of antidiuretic hormone on renal organic osmolytes in Brattleboro rats

1989 • 18 citations

Amino acid content in astroglial primary cultures from different brain regions during cultivation

1987 • 17 citations

Society for Pediatric Research Presidential Address New Functions for an Old Molecule

1987 • 17 citations

Enzymes of Fructose Metabolism in Human Kidney

1975 • 16 citations

Characteristics of ionic binding by rat renal tissue in vitro.

1984 • 16 citations

Intra-renal distribution of free amino acids in antidiuretic ruminants

1966 • 16 citations

Effect of osmotic shocks on rabbit kidney cortex slices

1983 • 15 citations

THE LOCALISATION OF SORBITOL PATHWAY ACTIVITY IN THE RAT RENAL CORTEX AND ITS RELATIONSHIP TO THE PATHOGENESIS OF THE RENAL COMPLICATIONS OF DIABETES MELLITUS

1975 • 14 citations

Energetics of Na+-dependent amino acid co-transport in Ehrlich ascites tumor cells

1987 • 14 citations

Anion exchange and volume regulation during metabolic blockade of renal cortical slices.

1979 • 14 citations

Effect of a hypo-osmotic shock on the volume and the ion content of rat kidney cortex slices

1980 • 14 citations

An inwardly-directed sodium-amino acid cotransporter influences steady-state cell volume in slices of rat renal papilla incubated in hyperosmotic media

1988 • 13 citations

Methylamine and polyol responses to salt loading in renal inner medulla

1989 • 12 citations

Element composition of tubule cells in the inner stripe of the renal outer medulla.

1989 • 10 citations

The Physiology of the Renal Tract in Pregnancy

1985 • 9 citations

Der Gehalt an Glycerylphosphorylcholin und Glycerylphosphoryl�thanolamin von Nierenmark und Nierenrinde hochreiner Wistarratten w�hrend forcierter Wasserdiurese und extrem langer Durst-Antidiurese

1964 • 9 citations

Adaptation to hyperosmolality in the rat

1980 • 7 citations

Development and inheritance of osmotic tolerance in a line of spontaneously transformed BALB/3T3 cells.

1986 • 6 citations

CELLULAR RESPONSE TO INJURY

1938 • 5 citations

Amino acid uptake in synaptosomal preparations

1988 • 5 citations

Deleted Work

1955 • 0 citations