The role of toxic oxygen species in inflammation with special reference to DNA damage

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

1989 • 1,273 citations

Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.

1987 • 1,152 citations

Role of metals in oxygen radical reactions

1985 • 1,149 citations

Free Radicals and Inflammation: Protection of Synovial Fluid by Superoxide Dismutase

1974 • 1,109 citations

BIOCHEMISTRY OF OXYGEN TOXICITY

1989 • 1,046 citations

Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair

1986 • 933 citations

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

1987 • 778 citations

Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide.

1988 • 614 citations

Free radicals, lipids and protein degradation

1986 • 556 citations

α1-Antitrypsin and the serpins: variation and countervariation

1985 • 384 citations

Iron Ion-dependent Modification of Bases in DNA by the Superoxide Radical-generating System Hypoxanthine/Xanthine Oxidase

1989 • 363 citations

Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity.

1982 • 352 citations

Significance of xanthine oxidase in capillary endothelial cells.

1986 • 333 citations

Absence of both cytochrome b−245 subunits from neutrophils in X-linked chronic granulomatous disease

1987 • 324 citations

DNA strand breaks, NAD metabolism, and programmed cell death

1986 • 303 citations

Oxygen Radicals in Biology and Medicine

1988 • 293 citations

HYPOXIC-REPERFUSION INJURY IN THE INFLAMED HUMAN JOINT

1989 • 290 citations

alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage.

1986 • 276 citations

Alterations in adenosine triphosphate and energy charge in cultured endothelial and P388D1 cells after oxidant injury.

1985 • 268 citations

A role for heat shock proteins in inflammation?

1988 • 262 citations

Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.

1984 • 253 citations

Oxidative DNA and RNA damage in the livers of Sprague-Dawley rats treated with the hepatocarcinogen 2-nitropropane.

1989 • 250 citations

Lipid peroxidation in rheumatoid arthritis: Thiobarbituric acid-reactive material and catalytic iron salts in synovial fluid from rheumatoid patients

1984 • 224 citations

Heparin-induced release of extracellular superoxide dismutase to human blood plasma

1987 • 222 citations

Antioxidant properties of the proteins caeruloplasmin, albumin and transferrin. A study of their activity in serum and synovial fluid from patients with rheumatoid arthritis

1986 • 213 citations

Synthesis in yeast of a functional oxidation-resistant mutant of human α1-antitrypsin

1984 • 209 citations

Cellular Antioxidant Defense Mechanisms

2019 • 203 citations

Formation of 8-hydroxydeoxyguanosine, hydroxyl free radical adduct of DNA in granulocytes exposed to the tumor promoter, tetradeconylphorbolacetate

1986 • 192 citations

Mitochondria and xanthine oxidase both generate reactive oxygen species in isolated perfused rat liver after hypoxic injury

1989 • 190 citations

Self-perpetuating mechanisms of immunoglobulin G aggregation in rheumatoid inflammation.

1985 • 175 citations

Evidence for reactive oxygen species inducing mutations in mammalian cells.

1986 • 175 citations

Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress

1988 • 174 citations

Mutagenesis by the autoxidation of iron with isolated DNA.

1988 • 158 citations

HORMONES AND LACTATION.

1964 • 142 citations

Superoxide anion production by the autoxidation of cytochrome P450cam

1974 • 139 citations

Oxidant injury of cells.

1987 • 135 citations

Cellular antioxidant defense mechanisms

1989 • 133 citations

SKIN DISEASE AND THE BOWEL.

1965 • 131 citations

Oxygen Radicals Acting as Chemical Messengers: A Hypothesis

1989 • 129 citations

Isolation and properties of oxidized alpha-1-proteinase inhibitor from human rheumatoid synovial fluid

1980 • 129 citations

Activated oxygen species at the origin of chromosome breakage and sister-chromatid exchanges

1982 • 120 citations

Oxidant-dependent metabolic activation of polycyclic aromatic hydrocarbons by phorbol ester-stimulated human polymorphonuclear leukocytes: possible link between inflammation and cancer.

1985 • 119 citations

Oxidant Production and Bactericidal Activity of Phagocytes

1986 • 108 citations

Altered Factor VIII in Acute Respiratory Failure

1982 • 105 citations

Cleavage and inactivation of alpha 1-antitrypsin by metalloproteinases released from neutrophils.

1988 • 104 citations

Hypoxia and oxygen toxicity.

1979 • 103 citations

Oxygen free radicals, inflammation, and synovitis: and synovitis: the current status.

1989 • 100 citations

Proteolytic inactivation of alpha-1-proteinase inhibitor by a neutrophil metalloproteinase.

1988 • 99 citations

Free radicals and Dupuytren's contracture.

1987 • 97 citations

Biologically-significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by some anti-inflammatory drugs

1987 • 87 citations

Xanthine oxidase mediates elastase-induced injury to isolated lungs and endothelium

1987 • 87 citations

MECHANISM OF EXACERBATION OF RHEUMATOID SYNOVITIS BY TOTAL-DOSE IRON-DEXTRAN INFUSION: IN-VIVO DEMONSTRATION OF IRON-PROMOTED OXIDANT STRESS

1987 • 78 citations

The mechanism of chondrocyte hydrogen peroxide damage. Depletion of intracellular ATP due to suppression of glycolysis caused by oxidation of glyceraldehyde-3-phosphate dehydrogenase.

1989 • 78 citations

Oxidative damage to lipids within the inflamed human joint provides evidence of radical-mediated hypoxic-reperfusion injury

1991 • 69 citations

Theories of Carcinogenesis

2007 • 64 citations

Bleomycin-induced cutaneous toxicity in the rat: analysis of histopathology and ultrastructure compared with progressive systemic sclerosis (scleroderma

1983 • 62 citations

A GENETICALLY ENGINEERED MUTANT OF α1-ANTITRYPSIN PROTECTS CONNECTIVE TISSUE FROM NEUTROPHIL DAMAGE AND MAY BE USEFUL IN LUNG DISEASE

1984 • 60 citations

ELEVATED von WILLEBRAND FACTOR ANTIGEN IN SYSTEMIC SCLEROSIS: RELATIONSHIP TO VISCERAL DISEASE

1988 • 54 citations

Human B lymphocytes show greater susceptibility to H2O2 toxicity than T lymphocytes.

1984 • 53 citations

Radiosensitivity of Peripheral Blood Lymphocytes in Autoimmune Disease

1985 • 53 citations

Synthesis of underpolymerized hyaluronic acid by fibroblasts cultured from rheumatoid and non-rheumatoid synovitis

1982 • 51 citations

Concentration and chemical state of copper in synovial fluid and blood serum of patients with rheumatoid arthritis.

1965 • 50 citations

Reactive oxygen species induce antigenic changes in DNA

1989 • 46 citations

Association of severe rheumatoid arthritis with heterozygosity for α‐antitrypsin deficiency

1980 • 46 citations

Proteinase inhibitors in human synovial fluid

1973 • 46 citations

Effects of oxidative stress on some physiochemical properties of caeruloplasmin

1989 • 45 citations

Properties of the superoxide-generating oxidase of B-lymphocyte cell lines. Determination of Michaelis parameters

1989 • 45 citations

Urine Biomarkers for Oxidative DNA Damage

1988 • 39 citations

The heat shock protein response and its role in inflammatory disease.

1990 • 38 citations

Molecular medicine: Therapy by instant evolution

1984 • 38 citations

Determination of 8-Hydroxydeoxyguanosine in Human Urine: a Possible Assay for in Vivo Oxidative DNA Damage

1988 • 38 citations

Free radicals inactivate human neutrophil elastase and its inhibitors with comparable efficiency

1989 • 33 citations

Differences in the Redox Balance in Human Rheumatoid and Non-rheumatoid Synovial Lining Cells

1973 • 30 citations

The Application of Quantitative Cytochemistry to the Study of Diseases of the Connective Tissues

1983 • 27 citations

JOINT SIZE INFLUENCE ON THE LEUCOCYTE COUNT OF INFLAMMATORY SYNOVIAL FLUIDS

1989 • 26 citations

Reactive Oxygen Species Selectively Deplete Normal T Lymphocytes Via a Hydroxyl Radical Dependent Mechanism

1987 • 26 citations

A Comparative Study of the Interactions of Bleomycin with Nuclei and Purified DNA

1989 • 22 citations

Increased sensitivity of lymphocytes from patients with systemic autoimmune diseases to DNA alkylation by the methylating carcinogen N-methyl-N-nitrosourea.

1988 • 20 citations

Deoxyribonucleic acid (DNA) damage induced by bleomycin-Fe(II) in vitro: Formation of 8-hydroxyguanine residues in DNA.

1989 • 18 citations

Interference of cartilage surface with interaction of granulocyte elastase with ?1-proteinase inhibitor

1987 • 17 citations

alpha 1 Antitrypsin (PI) allotypes in rheumatoid arthritis.

1986 • 17 citations

DNA damage and repair in immunologically active cells

1983 • 17 citations

The adrenochrome pathway. A potential catabolic route for adrenaline metabolism in inflammatory disease.

1985 • 16 citations

DNA damage and repair in immunologically active cells

1983 • 13 citations

Nucleosides and bases in synovial fluid from patients with rheumatoid arthritis and osteoarthritis

1988 • 12 citations

Lipoprotein Oxidation and Induction of Ferroxidase Activity in Stored Human Extracellular Fluids

1989 • 8 citations

The International Symposium on Biological Reactive Intermediates

2002 • 1 citations

Deleted Work

1955 • 0 citations