Detection of marker associations with a dominant disease gene in genetically complex and heterogeneous diseases.

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

1987 • 1,149 citations

Bipolar affective disorders linked to DNA markers on chromosome 11

1987 • 826 citations

Molecular Genetics of Inherited Variation in Human Color Vision

1986 • 777 citations

Estimation of linkage disequilibrium in randomly mating populations

1974 • 625 citations

Genetic linkage between X-chromosome markers and bipolar affective illness

1987 • 420 citations

A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands

1987 • 339 citations

Molecular genetic evidence for heterogeneity in manic depression

1987 • 252 citations

Tight linkage between a splicing mutation and a specific DNA haplotype in phenylketonuria

1986 • 249 citations

The detection of linkage disequilibrium between closely linked markers: RFLPs at the AI-CIII apolipoprotein genes.

1988 • 247 citations

Absence of Linkage of Chromosome 21q21 Markers to Familial Alzheimer's Disease

1988 • 245 citations

Close linkage of c-Harvey-ras-1 and the insulin gene to affective disorder is ruled out in three North American pedigrees

1987 • 223 citations

An ammo-acid substitution involved in phenylketonuria is in linkage disequilibrium with DNA haplotype 2

1987 • 178 citations

Sample sizes required to detect linkage disequilibrium between two or three loci

1975 • 171 citations

THE SAMPLING DISTRIBUTION OF LINKAGE DISEQUILIBRIUM UNDER AN INFINITE ALLELE MODEL WITHOUT SELECTION

1985 • 151 citations

A DNA Segment Encoding Two Genes Very Tightly Linked to Huntington's Disease

1987 • 108 citations

Human Genetics: The Molecular Challenge

1986 • 102 citations

THE SAMPLING DISTRIBUTION OF LINKAGE DISEQUILIBRIUM

1984 • 84 citations

DETECTION OF NONRANDOM ASSOCIATION OF ALLELES FROM THE DISTRIBUTION OF THE NUMBER OF HETEROZYGOUS LOCI IN A SAMPLE

1984 • 72 citations

Estimation of the marker gene frequency and linkage disequilibrium from conditional marker data.

1984 • 27 citations

Tracing the mutations in cystic fibrosis by means of closely linked DNA markers.

1989 • 17 citations

Race for Cystic Fibrosis Gene Nears End

1988 • 11 citations

Tracing the mutations in cystic fibrosis by means of closely linked DNA markers.

1989 • 7 citations