A tale of two termini:

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

Intracellular Aspects of the Process of Protein Synthesis

1975 • 3,560 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

On protein synthesis.

1958 • 1,174 citations

A SMALL PARTICULATE COMPONENT OF THE CYTOPLASM

1955 • 949 citations

The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency.

1991 • 795 citations

Initiation of Protein Synthesis in Eukaryotic Cells

1996 • 715 citations

Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G.

1996 • 679 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.

1993 • 660 citations

A MULTIPLE RIBOSOMAL STRUCTURE IN PROTEIN SYNTHESIS

1963 • 575 citations

The poly(A) binding protein is required for poly(A) shortening and 60S ribosomal subunit-dependent translation initiation

1989 • 561 citations

Mapping of Functional Domains in Eukaryotic Protein Synthesis Initiation Factor 4G (eIF4G) with Picornaviral Proteases

1995 • 541 citations

Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript.

1994 • 511 citations

Cap-independent enhancement of translation by a plant potyvirus 5' nontranslated region

1990 • 408 citations

ATP-dependent unwinding of messenger RNA structure by eukaryotic initiation factors.

1985 • 404 citations

Microsomal particles and protein synthesis

1958 • 391 citations

A common function for mRNA 5' and 3' ends in translation initiation in yeast.

1995 • 374 citations

Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation

1998 • 369 citations

mRNA poly(A) tail, a 3' enhancer of translational initiation.

1990 • 353 citations

Turnover Mechanisms of the Stable Yeast PGK1 mRNA

1995 • 341 citations

An essential component of the decapping enzyme required for normal rates of mRNA turnover

1996 • 328 citations

Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation

1997 • 314 citations

A Novel Functional Human Eukaryotic Translation Initiation Factor 4G

1998 • 297 citations

Human Eukaryotic Translation Initiation Factor 4G (eIF4G) Possesses Two Separate and Independent Binding Sites for eIF4A

1997 • 289 citations

Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form.

1994 • 285 citations

Heat shock-induced translational alterations in HeLa cells. Initiation factor modifications and the inhibition of translation.

1984 • 282 citations

Multiple functions for the poly(A)-binding protein in mRNA decapping and deadenylation in yeast.

1995 • 278 citations

Cap-dependent and cap-independent translation by internal initiation of mRNAs in cell extracts prepared from Saccharomyces cerevisiae.

1994 • 274 citations

Dual function of the messenger RNA cap structure in poly(A)-tail-promoted translation in yeast

1998 • 268 citations

Translation Initiation Factors eIF-iso4G and eIF-4B Interact with the Poly(A)-binding Protein and Increase Its RNA Binding Activity

1997 • 261 citations

eIF4G Dramatically Enhances the Binding of eIF4E to the mRNA 5′-Cap Structure

1997 • 235 citations

Mutations affecting stability and deadenylation of the yeast MFA2 transcript.

1992 • 228 citations

2 The Pathway and Mechanism of Eukaryotic Protein Synthesis

1996 • 225 citations

The C-terminal domain of eukaryotic protein synthesis initiation factor (eIF) 4G is sufficient to support cap-independent translation in the absence of eIF4E.

1996 • 207 citations

Messenger RNA deadenylylation precedes decapping in mammalian cells

1997 • 205 citations

Translation Initiation and Ribosomal Biogenesis: Involvement of a Putative rRNA Helicase and RPL46

1990 • 204 citations

Protein synthesis and protein phosphorylation during heat stress, recovery, and adaptation.

1989 • 203 citations

Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters.

1990 • 197 citations

Translational Efficiency Is Regulated by the Length of the 3′ Untranslated Region

1996 • 193 citations

The Yeast Pan2 Protein Is Required for Poly(A)-binding Protein-stimulated Poly(A)-nuclease Activity

1996 • 182 citations

Tales of poly(A): a review

1990 • 171 citations

RNA Recognition Motif 2 of Yeast Pab1p Is Required for Its Functional Interaction with Eukaryotic Translation Initiation Factor 4G

1998 • 165 citations

PAN3 Encodes a Subunit of the Pab1p-Dependent Poly(A) Nuclease in Saccharomyces cerevisiae

1996 • 160 citations

Possible Involvement of poly(A) in protein synthesks

1983 • 160 citations

A phylogenetically conserved sequence within viral 3' untranslated RNA pseudoknots regulates translation.

1993 • 153 citations

Five pseudoknots are present at the 204 nucleotides long 3' noncoding region of tobacco mosak virus RNA

1985 • 153 citations

RNA pseudoknot domain of tobacco mosaic virus can functionally substitute for a poly(A) tail in plant and animal cells.

1990 • 152 citations

7 Translational Control of GCN4: Gene-specific Regulation by Phosphorylation of elF2

1996 • 143 citations

3'-UTR-dependent deadenylation by the yeast poly(A) nuclease.

1992 • 140 citations

Wheat Germ Poly(A) Binding Protein Enhances the Binding Affinity of Eukaryotic Initiation Factor 4F and (iso)4F for Cap Analogues

1998 • 133 citations

The tobacco etch viral 5′ leader and poly(A) tail are functionally synergistic regulators of translation

1995 • 121 citations

Effect of sequence context at stop codons on efficiency of reinitiation in GCN4 translational control

1994 • 115 citations

Histone 3' ends: essential and regulatory functions.

1992 • 115 citations

The Phosphorylation State of Translation Initiation Factors Is Regulated Developmentally and following Heat Shock in Wheat

1997 • 114 citations

Circular polysomes predominate on the rough endoplasmic reticulum of somatotropes and mammotropes in the rat anterior pituitary

1987 • 114 citations

Cap binding protein complex that restores protein synthesis in heat-shocked Ehrlich cell lysates contains highly phosphorylated eIF-4E.

1990 • 110 citations

Poly(A) binds to initiation factors and increases cap-dependent translation in vitro.

1994 • 101 citations

Mechanism of inhibition of polypeptide chain initiation in heat-shocked Ehrlich cells involves reduction of eukaryotic initiation factor 4F activity.

1985 • 101 citations

The histone 3'-terminal stem-loop is necessary for translation in Chinese hamster ovary cells

1996 • 94 citations

Heat shock impairs the interaction of cap-binding protein complex with 5' mRNA cap.

1991 • 87 citations

The role of the 3'-untranslated region of non-polyadenylated plant viral mRNAs in regulating translational efficiency

1994 • 86 citations

The poly(A)‐binding protein facilitates in vitro translation of poly(A)‐rich mRNA

1988 • 84 citations

iPABP, an Inducible Poly(A)-Binding Protein Detected in Activated Human T Cells

1995 • 80 citations

Two structural domains of initiation factor eIF-4B are involved in binding to RNA.

1994 • 73 citations

Effect of sequence context at stop codons on efficiency of reinitiation in GCN4 translational control.

1994 • 72 citations

19 Initiation of Translation by Picornavirus RNAs

1996 • 65 citations

Regulation of Hemoglobin Synthesis

1972 • 59 citations

Heat Shock Disrupts Cap and Poly(A) Tail Function during Translation and Increases mRNA Stability of Introduced Reporter mRNA

1995 • 54 citations

The Role of Ribosomal Subunits in Mammalian Cells

1969 • 50 citations

In vitro synthesis of human protein synthesis initiation factor 4 gamma and its localization on 43 and 48 S initiation complexes.

1994 • 45 citations

Haemoglobin Synthesis and Polysomes in Intact Reticulocytes

1965 • 42 citations

Mutational Analysis of the Functional Domains of the Large Subunit of the Isozyme Form of Wheat Initiation Factor eIF4F

1996 • 36 citations

Ribosomal Association of Poly(A)-binding Protein in Poly(A)-deficient Saccharomyces cerevisiae

1996 • 34 citations

Electron microscopic visualization of a discrete class of giant translation units in salivary gland cells of Chironomus tentans

1982 • 32 citations

Serum and insulin regulate cap function in 3T3-L1 cells.

1994 • 23 citations

The effect of the length of the 3′‐untranslated region on expression in plants

1996 • 19 citations

Secretory protein synthesis in Chironomus salivary gland cells is not coupled with protein translocation across endoplasmic reticulum membranes

1989 • 18 citations

5'-Terminal caps, cap-binding proteins and eukaryotic mRNA function.

1982 • 10 citations