Early Specialized Cardiovascular Intervention Based on Impedance Cardiography in Locally Advanced Non-small Cell Lung Cancer Patients

NCT04980716

PHASE3INTERVENTIONAL

Sun Yat-sen University

524 participants

Started 2021-06-01 · Completed 2026-07-01

Status: Recruiting (as of 12-23-2025)

Conditions

Non-small Cell Lung CancerCardiovascular Complication

Interventions

DRUG: Multiple cardiovascular drugs related to "Golden Triangle"

Linked Papers (from SciSciNet-V2)

Total Papers25

Background

8

Result

0

Derived

0

Unknown

17

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

This is a prospective, randomized, controlled, multi-center phase III clinical trial that intends to evaluate the role of early cardiovascular intervention based on impedance cardiography in patients with locally advanced non-small cell lung cancer receiving radical radiochemotherapy±immunotherapy.

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Background Papers16

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer

7,844 citations

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer

7,844 citations

Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study

1,779 citations

Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study

1,779 citations

VEGF Inhibition and Renal Thrombotic Microangiopathy

1,408 citations

VEGF Inhibition and Renal Thrombotic Microangiopathy

1,408 citations

Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy

Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy

Cardiac Toxicity After Radiotherapy for Stage III Non–Small-Cell Lung Cancer: Pooled Analysis of Dose-Escalation Trials Delivering 70 to 90 Gy

Cardiac Toxicity After Radiotherapy for Stage III Non–Small-Cell Lung Cancer: Pooled Analysis of Dose-Escalation Trials Delivering 70 to 90 Gy

Cardiac Events After Radiation Therapy: Combined Analysis of Prospective Multicenter Trials for Locally Advanced Non–Small-Cell Lung Cancer

Cardiac Events After Radiation Therapy: Combined Analysis of Prospective Multicenter Trials for Locally Advanced Non–Small-Cell Lung Cancer

Radiation-induced heart disease: a review of classification, mechanism and prevention

Radiation-induced heart disease: a review of classification, mechanism and prevention

The Role of Biomarkers in Cardio-Oncology

The Role of Biomarkers in Cardio-Oncology

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers17

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

74,955 citations

Early Detection of Anthracycline Cardiotoxicity and Improvement With Heart Failure Therapy

1,395 citations

Use of Myocardial Strain Imaging by Echocardiography for the Early Detection of Cardiotoxicity in Patients During and After Cancer Chemotherapy

Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management

Necitumumab plus gemcitabine and cisplatin versus gemcitabine and cisplatin alone as first-line therapy in patients with stage IV squamous non-small-cell lung cancer (SQUIRE): an open-label, randomised, controlled phase 3 trial

PD-1 deficiency results in the development of fatal myocarditis in MRL mice

Phase II study of docetaxel for recurrent or metastatic non-small-cell lung cancer.

Cardiac Radiation Dose, Cardiac Disease, and Mortality in Patients With Lung Cancer

Is cardiac toxicity a relevant issue in the radiation treatment of esophageal cancer?

Peak Cardiac Power Output, Measured Noninvasively, Is a Powerful Predictor of Outcome in Chronic Heart Failure

Cardiovascular Disease Risk in a Large, Population-Based Cohort of Breast Cancer Survivors

Modern Radiation Therapy and Cardiac Outcomes in Breast Cancer

Prognostic Significance and Measurement of Exercise-Derived Hemodynamic Variables in Patients With Heart Failure

Transthoracic Impedance Accurately Estimates Pulmonary Wedge Pressure in Patients With Decompensated Chronic Heart Failure

Impedance cardiography – Old method, new opportunities. Part I. Clinical applications

Gemcitabine-induced Pleuropericardial Effusion in a Patient with Pancreatic Cancer

Impedance cardiography for monitoring changes in cardiac output.