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PD-1 Antibody and Lenvatinib Plus TACE on Downstaging BCLC B/C HCC
NCT04974281
EARLY_PHASE1INTERVENTIONAL
Fudan University
50 participants
Started 2021-01-01 · Completed 2022-12-31
Status: Unknown (as of 12-23-2025)
Conditions
Hepatocellular Carcinoma
Interventions
Linked Papers (from SciSciNet-V2)
Total Papers5
Background
2Result
0Derived
0Unknown
3Total Citations Per Year
Brief Summary
The purpose of this study is to assess the difference of safety and efficacy about PD-1 Antibody and Lenvatinib Plus transcatheter arterial chemoembolization (TACE) on downstaging hepatocellular carcinoma with BCLC B/C.
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Background Papers4
Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial
2019
540 citations
Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial
2019
540 citations
Lenvatinib plus anti-PD-1 antibody combination treatment activates CD8+ T cells through reduction of tumor-associated macrophage and activation of the interferon pathway
2019
351 citations
Lenvatinib plus anti-PD-1 antibody combination treatment activates CD8+ T cells through reduction of tumor-associated macrophage and activation of the interferon pathway
2019
351 citations
Result Papers0
No result papers linked
Derived Papers0
No derived papers linked
Unknown Papers3
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2018
74,955 citations
Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial
2018
4,279 citations
Lipiodol transarterial chemoembolization for hepatocellular carcinoma: A systematic review of efficacy and safety data
2016
597 citations