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Efficacy and Safety of Sirolimus in COVID-19 Infection
NCT04461340
PHASE2INTERVENTIONAL
Alexandria University
40 participants
Started 2020-08-15 · Completed 2020-11-30
Status: Unknown (as of 12-23-2025)
Conditions
COVID 19
Interventions
Linked Papers (from SciSciNet-V2)
Total Papers14
Background
11Result
0Derived
0Unknown
3Total Citations Per Year
Brief Summary
This research is planned to illustrate the efficacy and safety of sirolimus as an adjuvant agent to the standard treatment protocol against COVID-19 infection
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Background Papers22
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
2020
49,017 citations
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
2020
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
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A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster
2020
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A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster
2020
9,328 citations
Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China
2020
4,933 citations
Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China
2020
4,933 citations
Clinical and immunological features of severe and moderate coronavirus disease 2019
2020
4,668 citations
Clinical and immunological features of severe and moderate coronavirus disease 2019
2020
4,668 citations
A Review of Coronavirus Disease-2019 (COVID-19)
2020
3,436 citations
A Review of Coronavirus Disease-2019 (COVID-19)
2020
3,436 citations
Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology
2017
2,515 citations
Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology
2017
2,515 citations
Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study
2020
593 citations
Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study
2020
593 citations
Antiviral Potential of ERK/MAPK and PI3K/AKT/mTOR Signaling Modulation for Middle East Respiratory Syndrome Coronavirus Infection as Identified by Temporal Kinome Analysis
2014
388 citations
Antiviral Potential of ERK/MAPK and PI3K/AKT/mTOR Signaling Modulation for Middle East Respiratory Syndrome Coronavirus Infection as Identified by Temporal Kinome Analysis
2014
388 citations
Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer
2012
142 citations
Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer
2012
142 citations
Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and inflammatory cell infiltration
2018
75 citations
Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and inflammatory cell infiltration
2018
75 citations
Result Papers0
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Derived Papers0
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Unknown Papers3
Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2
2020
1,580 citations
Drug treatment options for the 2019-new coronavirus (2019-nCoV)
2020
1,174 citations
Adjuvant Treatment With a Mammalian Target of Rapamycin Inhibitor, Sirolimus, and Steroids Improves Outcomes in Patients With Severe H1N1 Pneumonia and Acute Respiratory Failure*
2013
133 citations