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TWICE-IRI: Optimization of Second-line Therapy With Aflibercept, Irinotecan (Day 1 or Day 1,3), 5-Fluorouracile and Folinic Acid in Patients With Metastatic Colorectal Cancer. A Randomized Phase III Study.
NCT04392479
PHASE3INTERVENTIONAL
Hôpital Franco-Britannique-Fondation Cognacq-Jay
202 participants
Started 2020-09-02 · Completed 2024-06
Status: Unknown (as of 12-23-2025)
Conditions
Cancer ColorectalMetastasis
Interventions
Linked Papers (from SciSciNet-V2)
Total Papers19
Background
3Result
0Derived
0Unknown
16Total Citations Per Year
Brief Summary
Optimization of second-line therapy with aflibercept, irinotecan (day1 or day 1,3), 5fluorouracile and folinic acid in patients with metastatic colorectal cancer. A randomized Phase III study.
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Background Papers6
<scp>PEPCOL</scp>: a <scp>GERCOR</scp> randomized phase <scp>II</scp> study of nanoliposomal irinotecan <scp>PEP</scp>02 (<scp>MM</scp>‐398) or irinotecan with leucovorin/5‐fluorouracil as second‐line therapy in metastatic colorectal cancer
2016
45 citations
<scp>PEPCOL</scp>: a <scp>GERCOR</scp> randomized phase <scp>II</scp> study of nanoliposomal irinotecan <scp>PEP</scp>02 (<scp>MM</scp>‐398) or irinotecan with leucovorin/5‐fluorouracil as second‐line therapy in metastatic colorectal cancer
2016
45 citations
A phase II study of FOLFIRI-3 (double infusion of irinotecan combined with LV5FU) after FOLFOX in advanced colorectal cancer patients
2006
40 citations
A phase II study of FOLFIRI-3 (double infusion of irinotecan combined with LV5FU) after FOLFOX in advanced colorectal cancer patients
2006
40 citations
FOLFIRI3-aflibercept in previously treated patients with metastatic colorectal cancer
2018
10 citations
FOLFIRI3-aflibercept in previously treated patients with metastatic colorectal cancer
2018
10 citations
Result Papers0
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Derived Papers0
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Unknown Papers16
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2018
74,955 citations
FOLFIRI Followed by FOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer: A Randomized GERCOR Study
2003
2,844 citations
Addition of Aflibercept to Fluorouracil, Leucovorin, and Irinotecan Improves Survival in a Phase III Randomized Trial in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin-Based Regimen
2012
1,299 citations
Randomized Phase III Study of Panitumumab With Fluorouracil, Leucovorin, and Irinotecan (FOLFIRI) Compared With FOLFIRI Alone As Second-Line Treatment in Patients With Metastatic Colorectal Cancer
2010
971 citations
Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study
2015
837 citations
Pathologic Response to Preoperative Chemotherapy: A New Outcome End Point After Resection of Hepatic Colorectal Metastases
2008
581 citations
Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery
2006
487 citations
Time until definitive quality of life score deterioration as a means of longitudinal analysis for treatment trials in patients with metastatic pancreatic adenocarcinoma
2010
99 citations
Sequence-dependent growth inhibition and DNA damage formation by the irinotecan–5-fluorouracil combination in human colon carcinoma cell lines
1999
97 citations
Sequence-dependent activity of the irinotecan-5FU combination in human colon-cancer model HT-29 in vitro and in vivo.
1997
88 citations
Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN-38) to 5-fluorouracil and folinic acid in HCT-8 cells: elevated dTTP pools and enhanced cytotoxicity
1998
72 citations
Sequence Effect of Irinotecan and Fluorouracil Treatment on Pharmacokinetics and Toxicity in Chemotherapy-Naive Metastatic Colorectal Cancer Patients
2001
55 citations
Efficacy of FOLFIRI-3 (irinotecan D1,D3 combined with LV5-FU) or other irinotecan-based regimens in oxaliplatin-pretreated metastatic colorectal cancer in the GERCOR OPTIMOX1 study
2009
42 citations
Bimonthly Leucovorin, Infusion 5-Fluorouracil, Hydroxyurea, and Irinotecan (FOLFIRI-2) for Pretreated Metastatic Colorectal Cancer
2003
29 citations
Role of leucovorin dosing and administration schedule
1995
15 citations
Fluorouracil, leucovorin and irinotecan associated with aflibercept can induce microscopic colitis in metastatic colorectal cancer patients
2015
6 citations