Neurobiology of Bulimia Nervosa

NCT04225221

PHASE2INTERVENTIONAL

University of North Carolina, Chapel Hill

10 participants

Started 2020-02-24 · Completed 2022-04-04

Status: Completed (as of 12-23-2025)

Conditions

Bulimia Nervosa

Interventions

DRUG: Estradiol DRUG: Micronized progesterone DRUG: Leuprolide Acetate DRUG: Placebo Oral Capsule

Linked Papers (from SciSciNet-V2)

Total Papers37

Background

13

Result

0

Derived

0

Unknown

24

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

This pilot study experimentally manipulates ovarian hormones to examine the direct impact of estrogen (E2) and progesterone (P4) on binge eating symptom burden and the behavioral reward response in women with bulimia nervosa (n=15). This is completed by taking medications that change ovarian hormone levels. This line of research could lead to the development of pharmacological interventions developed to target specific areas of the brain, brain receptors, or pathways identified to be involved in the mechanism underlying ovarian hormone change and binge eating.

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Background Papers26

Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods

Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods

Modulation of cognition-specific cortical activity by gonadal steroids: A positron-emission tomography study in women

Modulation of cognition-specific cortical activity by gonadal steroids: A positron-emission tomography study in women

Premenstrual Dysphoric Disorder Symptoms Following Ovarian Suppression: Triggered by Change in Ovarian Steroid Levels But Not Continuous Stable Levels

Premenstrual Dysphoric Disorder Symptoms Following Ovarian Suppression: Triggered by Change in Ovarian Steroid Levels But Not Continuous Stable Levels

Ovarian hormones and binge eating: exploring associations in community samples

Ovarian hormones and binge eating: exploring associations in community samples

Estradiol, Dopamine and Motivation

Estradiol, Dopamine and Motivation

Advances from neuroimaging studies in eating disorders

Advances from neuroimaging studies in eating disorders

The role of reproductive hormones in the development and maintenance of eating disorders

The role of reproductive hormones in the development and maintenance of eating disorders

Impact of Physiologic Estrogen Replacement on Anxiety Symptoms, Body Shape Perception, and Eating Attitudes in Adolescent Girls With Anorexia Nervosa

Impact of Physiologic Estrogen Replacement on Anxiety Symptoms, Body Shape Perception, and Eating Attitudes in Adolescent Girls With Anorexia Nervosa

Pharmacologically Induced Hypogonadism and Sexual Function in Healthy Young Women and Men

Pharmacologically Induced Hypogonadism and Sexual Function in Healthy Young Women and Men

Estrogen moderates genetic influences on binge eating during puberty: Disruption of normative processes?

Estrogen moderates genetic influences on binge eating during puberty: Disruption of normative processes?

Effects of Pharmacologically Induced Hypogonadism on Mood and Behavior in Healthy Young Women

Effects of Pharmacologically Induced Hypogonadism on Mood and Behavior in Healthy Young Women

ACTH and Cortisol Response to Dex/CRH Testing in Women with and without Premenstrual Dysphoria during GnRH Agonist-Induced Hypogonadism and Ovarian Steroid Replacement

ACTH and Cortisol Response to Dex/CRH Testing in Women with and without Premenstrual Dysphoria during GnRH Agonist-Induced Hypogonadism and Ovarian Steroid Replacement

Association of premenstrual syndrome and premenstrual dysphoric disorder with bulimia nervosa and binge‐eating disorder in a nationally representative epidemiological sample

Association of premenstrual syndrome and premenstrual dysphoric disorder with bulimia nervosa and binge‐eating disorder in a nationally representative epidemiological sample

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers24

Postmenopausal Estrogen Therapy and Cardiovascular Disease

2,008 citations

FMRI Visualization of Brain Activity during a Monetary Incentive Delay Task

1,346 citations

Effects of Gonadal Steroids in Women With a History of Postpartum Depression

GnRH agonist (buserelin) or hCG for ovulation induction in GnRH antagonist IVF/ICSI cycles: a prospective randomized study

Development and validation of the Eating Pathology Symptoms Inventory (EPSI).

Sensitivity to reward and punishment in eating disorders

Gray's model of personality and addiction

The effectiveness of GnRHa with and without ‘add‐back’ therapy in treating premenstrual syndrome: a meta analysis

Ovarian hormones and binge eating in bulimia nervosa

Effects of natural progesterone on the morphology of the endometrium in patients with primary ovarian failure

Optimization of estradiol supplementation during the luteal phase improves the pregnancy rate in women undergoing in vitro fertilization–embryo transfer cycles

Cortisol Response to Ovine Corticotropin-Releasing Hormone in a Model of Pregnancy and Parturition in Euthymic Women with and without a History of Postpartum Depression

Sex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression

Symptom fluctuation in bulimia nervosa: relation to menstrual-cycle phase and cortisol levels

Luteal support with micronized progesterone following in-vitro fertilization using a down-regulation protocol with gonadotrophin-releasing hormone agonist: a comparative study between vaginal and oral administration

Effects of an antiandrogenic oral contraceptive on appetite and eating behavior in bulimic women

Estradiol is a critical regulator of food-reward behavior

Addition of estradiol to progesterone for luteal supplementation in patients stimulated with GnRH antagonist/rFSH for IVF: a randomized controlled trial

Prevention of bone loss and hypoestrogenic symptoms by estrogen and interrupted progestogen add-back in long-term GnRH-agonist down-regulated patients with endometriosis and premenstrual syndrome

Pronuclear stage cryopreservation after intracytoplasmic sperm injection and conventional IVF: implications for timing of the freeze

Premenstrual exacerbation of bulimia

Fibrinolytic parameters in women undergoing ovulation induction

Differential Behavioral Effects of Gonadal Steroids in Women With and in Those Without Premenstrual Syndrome

A case of symptom relapse post placement of intrauterine device (IUD) in a patient with bulimia nervosa: consequence or coincidence