Determination of Microbiological Factors Associated With Poor Response to Neoadjuvant Treatment in Rectal Cancers

NCT04103567

NAINTERVENTIONAL

Institut du Cancer de Montpellier - Val d'Aurelle

220 participants

Started 2020-01-14 · Completed 2030-01-30

Status: Recruiting (as of 12-23-2025)

Conditions

Rectal Cancer

Interventions

OTHER: Biological collection

Linked Papers (from SciSciNet-V2)

Total Papers15

Background

3

Result

0

Derived

0

Unknown

12

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

The objective of this project is to determine in a non-invasive manner (fecal samples) the predictive value of the intestinal microbiota and the presence of genotoxin-producing bacteria on the response to neoadjuvant treatment in rectal cancer. This could lead to a better understanding and selection of patients for personalized treatment in rectal cancer.

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Background Papers6

Operative Versus Nonoperative Treatment for Stage 0 Distal Rectal Cancer Following Chemoradiation Therapy

1,647 citations

Operative Versus Nonoperative Treatment for Stage 0 Distal Rectal Cancer Following Chemoradiation Therapy

1,647 citations

High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer

High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer

Microbial markers in colorectal cancer detection and/or prognosis

Microbial markers in colorectal cancer detection and/or prognosis

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers12

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

74,955 citations

Preoperative versus Postoperative Chemoradiotherapy for Rectal Cancer

5,705 citations

MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT

2,394 citations

Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial

1,705 citations

Pathological features of rectal cancer after preoperative radiochemotherapy

1,289 citations

Escherichia coli Induces DNA Double-Strand Breaks in Eukaryotic Cells

Microbiota: a key orchestrator of cancer therapy

Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis

Colonization of the Human Gut by E. coli and Colorectal Cancer Risk

Organ preservation for rectal cancer (GRECCAR 2): a prospective, randomised, open-label, multicentre, phase 3 trial

Cyclomodulins: bacterial effectors that modulate the eukaryotic cell cycle

Tailored Treatment Strategy for Locally Advanced Rectal Carcinoma Based on the Tumor Response to Induction Chemotherapy: Preliminary Results of the French Phase II Multicenter GRECCAR4 Trial