Effect of a Dietary Intervention on Intracellular Lipid Levels, Insulin Sensitivity, and Glycemic Control in Type 2 Diabetes

NCT04088981

NAINTERVENTIONAL

Physicians Committee for Responsible Medicine

0

Started 2025-07 · Completed 2026-07

Status: Withdrawn (as of 12-23-2025)

Conditions

Diabetes Mellitus, Type 2

Interventions

BEHAVIORAL: Dietary intervention

Linked Papers (from SciSciNet-V2)

Total Papers19

Background

4

Result

0

Derived

0

Unknown

15

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

The purpose of this study is to compare the effects of a low-fat, plant-based dietary intervention and a portion-controlled dietary intervention (compliant with current American Diabetes Association (ADA) guidelines) on changes in intramyocellular and hepatocellular lipid content in adults with type 2 diabetes. Changes in insulin sensitivity and glycemic control will also be assessed in this study. The study duration is 44 weeks.

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Background Papers8

Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes

Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes

Effects of Pioglitazone on Intramyocellular Fat Metabolism in Patients with Type 2 Diabetes Mellitus

Effects of Pioglitazone on Intramyocellular Fat Metabolism in Patients with Type 2 Diabetes Mellitus

Intrahepatic and intramyocellular lipids are determinants of insulin resistance in prepubertal children

Intrahepatic and intramyocellular lipids are determinants of insulin resistance in prepubertal children

Liver and Muscle in Morbid Obesity: The Interplay of Fatty Liver and Insulin Resistance

Liver and Muscle in Morbid Obesity: The Interplay of Fatty Liver and Insulin Resistance

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers15

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1 H NMR spectroscopy study

1,267 citations

Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

A High-Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle

Intramuscular lipid content is increased in obesity and decreased by weight loss

Assessment of Skeletal Muscle Triglyceride Content by 1H Nuclear Magnetic Resonance Spectroscopy in Lean and Obese Adolescents

Insulin Resistance in Morbid Obesity

Effects of Intravenous and Dietary Lipid Challenge on Intramyocellular Lipid Content and the Relation With Insulin Sensitivity in Humans

Diet, weight loss, and liver health in nonalcoholic fatty liver disease: Pathophysiology, evidence, and practice

Intramyocellular Lipids: Anthropometric Determinants and Relationships with Maximal Aerobic Capacity and Insulin Sensitivity

Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance

Metformin Suppresses Lipid Accumulation in Skeletal Muscle by Promoting Fatty Acid Oxidation

Lipid Mobilization Following Roux-en-Y Gastric Bypass Examined by Magnetic Resonance Imaging and Spectroscopy

[Decrease of liver fat content by aerobic exercise or metformin therapy in overweight or obese women].

Effects of pioglitazone versus glimepiride exposure on hepatocellular fat content in type 2 diabetes

Further Lowering of Muscle Lipid Oxidative Capacity in Obese Subjects after Biliopancreatic Diversion