Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury

NCT03602014

PHASE4INTERVENTIONAL

James J. Peters Veterans Affairs Medical Center

22 participants

Started 2018-06-01 · Completed 2021-12-31

Status: Completed (as of 12-23-2025)

Conditions

Hypotension, OrthostaticHypotensionSpinal Cord Injuries

Interventions

DRUG: Northera OTHER: Placebo

Linked Papers (from SciSciNet-V2)

Total Papers115

Background

29

Result

0

Derived

0

Unknown

86

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

The goal of this study is to determine the efficacy of the drug Droxidopa (Northera) in increasing blood pressure in subject with hypotension, low blood pressure, which is classified as blood pressure less than 110/70 in males and 100/70 in females. The first aim is to determine the proportion of subject with Spinal Cord Injury (SCI) who have a normotensive response to Droxidopa. The second is to determine the proportion of subject with SCI who express a hypertensive response to Droxidopa. A Normal blood pressure ranges from 111-139 in males and 101-139 in females and a hypertensive blood pressure is anything higher than 140 in males and females. The study would take place in James J. Peters VA Medical Center (JJPVAMC) and The Icahn School of Medicine at Mount Sinai (ISMMS) in Manhattan, New York.

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Background Papers58

Orthostatic hypotension predicts all-cause mortality and coronary events in middle-aged individuals (The Malmo Preventive Project)

Orthostatic hypotension predicts all-cause mortality and coronary events in middle-aged individuals (The Malmo Preventive Project)

Droxidopa for neurogenic orthostatic hypotension

Droxidopa for neurogenic orthostatic hypotension

Life-threatening outcomes associated with autonomic dysreflexia: A clinical review

Life-threatening outcomes associated with autonomic dysreflexia: A clinical review

Symptoms of low blood pressure: a population study.

Symptoms of low blood pressure: a population study.

Association of low blood pressure with anxiety and depression: the Nord-Trondelag Health Study

Association of low blood pressure with anxiety and depression: the Nord-Trondelag Health Study

A Systematic Review of the Management of Orthostatic Hypotension After Spinal Cord Injury

A Systematic Review of the Management of Orthostatic Hypotension After Spinal Cord Injury

Low blood pressure, low mood?

Low blood pressure, low mood?

Low blood pressure and depression in older men: a population based study

Low blood pressure and depression in older men: a population based study

Regional Neurovascular Coupling and Cognitive Performance in Those with Low Blood Pressure Secondary to High-Level Spinal Cord Injury: Improved by Alpha-1 Agonist Midodrine Hydrochloride

Regional Neurovascular Coupling and Cognitive Performance in Those with Low Blood Pressure Secondary to High-Level Spinal Cord Injury: Improved by Alpha-1 Agonist Midodrine Hydrochloride

Cognitive performance in hypotensive persons with spinal cord injury

Cognitive performance in hypotensive persons with spinal cord injury

Droxidopa in neurogenic orthostatic hypotension

Droxidopa in neurogenic orthostatic hypotension

Low systolic blood pressure and self perceived wellbeing in middle aged men.

Low systolic blood pressure and self perceived wellbeing in middle aged men.

Does constitutional hypotension exist?

Does constitutional hypotension exist?

Incidence of Autonomic Dysreflexia and Silent Autonomic Dysreflexia in Men With Spinal Cord Injury Undergoing Sperm Retrieval: Implications for Clinical Practice

Incidence of Autonomic Dysreflexia and Silent Autonomic Dysreflexia in Men With Spinal Cord Injury Undergoing Sperm Retrieval: Implications for Clinical Practice

Orthostatic Hypotension and Cognitive Function: The Atherosclerosis Risk in Communities Study

Orthostatic Hypotension and Cognitive Function: The Atherosclerosis Risk in Communities Study

Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine

Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine

Decentralized cardiovascular autonomic control and cognitive deficits in persons with spinal cord injury

Decentralized cardiovascular autonomic control and cognitive deficits in persons with spinal cord injury

Impact of Blood Pressure Dysregulation on Health-Related Quality of Life in Persons With Spinal Cord Injury: Development of a Conceptual Model

Impact of Blood Pressure Dysregulation on Health-Related Quality of Life in Persons With Spinal Cord Injury: Development of a Conceptual Model

A retrospective chart review of heart rate and blood pressure abnormalities in veterans with spinal cord injury

A retrospective chart review of heart rate and blood pressure abnormalities in veterans with spinal cord injury

Neurogenic orthostatic hypotension in Parkinson&#39;s disease: evaluation, management, and emerging role of droxidopa

Neurogenic orthostatic hypotension in Parkinson&#39;s disease: evaluation, management, and emerging role of droxidopa

A prospective report on the prevalence of heart rate and blood pressure abnormalities in veterans with spinal cord injuries

A prospective report on the prevalence of heart rate and blood pressure abnormalities in veterans with spinal cord injuries

Normalization of Supine Blood Pressure After Nitric Oxide Synthase Inhibition in Persons With Tetraplegia

Normalization of Supine Blood Pressure After Nitric Oxide Synthase Inhibition in Persons With Tetraplegia

Effects of midodrine and L-NAME on systemic and cerebral hemodynamics during cognitive activation in spinal cord injury and intact controls

Effects of midodrine and L-NAME on systemic and cerebral hemodynamics during cognitive activation in spinal cord injury and intact controls

Acute Onset of Intracerebral Hemorrhage due to Autonomic Dysreflexia

Acute Onset of Intracerebral Hemorrhage due to Autonomic Dysreflexia

Prevalence of Abnormal Systemic Hemodynamics in Veterans With and Without Spinal Cord Injury

Orthostatic responses to anticholinesterase inhibition in spinal cord injury

Prevalence of Abnormal Systemic Hemodynamics in Veterans With and Without Spinal Cord Injury

Orthostatic responses to anticholinesterase inhibition in spinal cord injury

Neurogenic orthostatic hypotension &ndash; management update and role of droxidopa

Neurogenic orthostatic hypotension &ndash; management update and role of droxidopa

Refractory orthostatic hypotension in a patient with a spinal cord injury: Treatment with droxidopa

Refractory orthostatic hypotension in a patient with a spinal cord injury: Treatment with droxidopa

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers86

The Association Between Midlife Blood Pressure Levels and Late-Life Cognitive Function

Orthostatic hypotension in older adults. The Cardiovascular Health Study. CHS Collaborative Research Group.

Cardiovascular consequences of loss of supraspinal control of the sympathetic nervous system after spinal cord injury

Orthostatic Hypotension Predicts Mortality in Elderly Men

Relationship of life satisfaction to impairment, disability, and handicap among persons with spinal cord injury living in the community.

Orthostatic Hypotension as a Risk Factor for Stroke

Cardiovascular abnormalities accompanying acute spinal cord injury in humans: Incidence, time course and severity

Orthostatic hypotension following spinal cord injury: understanding clinical pathophysiology

Orthostatic Hypotension Predicts Mortality in Middle-Aged Adults

Pyridostigmine Treatment Trial in Neurogenic Orthostatic Hypotension

Orthostatic hypotension and the incidence of coronary heart disease: the atherosclerosis risk in communities study

A Pilot Randomized Trial of Induced Blood Pressure Elevation: Effects on Function and Focal Perfusion in Acute and Subacute Stroke

Orthostatic Hypotension and Autonomic Pathways after Spinal Cord Injury

Autonomic Dysreflexia in Acute Spinal Cord Injury: An Under-Recognized Clinical Entity

Orthostatic Hypotension-Related Hospitalizations in the United States

Depression After Spinal Cord Injury: Comorbidities, Mental Health Service Use, and Adequacy of Treatment

Assessment of autonomic dysfunction following spinal cord injury: Rationale for additions to International Standards for Neurological Assessment

Plasma Catecholamines, Plasma Renin Activity and Plasma Aldosterone in Tetraplegic Man, Horizontal and Tilted

A Longitudinal Study of Depression From 1 to 5 Years After Spinal Cord Injury

The prevalence of orthostatic hypotension during physiotherapy treatment in patients with an acute spinal cord injury

Norepinephrine Precursor Therapy in Neurogenic Orthostatic Hypotension

Co-occurrence of Metabolic Syndrome With Depression and Anxiety in Young Adults: The Northern Finland 1966 Birth Cohort Study

Factors associated with the quality of life of long-term spinal cord injured persons

Effect of anxiety and depression on blood pressure: 11-year longitudinal population study

Droxidopa for the <scp>S</scp>hort‐<scp>T</scp>erm <scp>T</scp>reatment of <scp>S</scp>ymptomatic <scp>N</scp>eurogenic <scp>O</scp>rthostatic <scp>H</scp>ypotension in <scp>P</scp>arkinson's <scp>D</scp>isease (n<scp>OH</scp>306<scp>B</scp>)

Relationship between orthostatic hypotension and cognitive impairment in the elderly

Population-Based Study on the Prevalence and Correlates of Orthostatic Hypotension/Hypertension and Orthostatic Dizziness

The Art and Science of Nondisease

The treatment of neurogenic orthostatic hypotension with 3,4-DL-threo-dihydroxyphenylserine

Low blood pressure and risk of depression in the elderly

Cognitive performance and cerebral blood flow in essential hypotension

L-dihydroxyphenylserine (Droxidopa): a new therapy for neurogenic orthostatic hypotension

Essential Hypotension Is Accompanied by Deficits in Attention and Working Memory

L-dihydroxyphenylserine (Droxidopa) in the treatment of orthostatic hypotension

Circadian blood pressure rhythm in patients with higher and lower spinal cord injury

Autonomic Dysreflexia and Sudden Death in People With Traumatic Spinal Cord Injury

Orthostatic Hypotension Is Associated With Lower Cognitive Performance in Adults Aged 50 Plus With Supine Hypertension

Enhancement of cerebral blood flow and cognitive performance following pharmacological blood pressure elevation in chronic hypotension

Cognitive Performance in Orthostatic Hypotension: Findings from a Nationally Representative Sample

Orthostatic Hypotension, Hypotension and Cognitive Status: Early Comorbid Markers of Primary Dementia?

Effect of tilting on the cardiovascular responses and plasma catecholamine levels in spinal man

Relationship Between Low Blood Pressure and Depressive Symptomatology in Older People

Acetylcholinesterase Inhibition in Patients With Orthostatic Intolerance

Blood pressure changes during sexual stimulation, ejaculation and midodrine treatment in men with spinal cord injury

The blood pressure in paraplegia I

Orthostatic Hypotension in Spinal Cord Injured Patients

Autonomic Dysreflexia

Clinical pharmacokinetics of the norepinephrine precursor L-threo-DOPS in primary chronic autonomic failure

Early contingent negative variation of the EEG and attentional flexibility are reduced in hypotension

Cardiac Consequences of Autonomic Dysreflexia in Spinal Cord Injury

Midodrine hydrochloride and the treatment of orthostatic hypotension in tetraplegia: two cases and a review of the literature

Cardiac autonomic responses to progressive head-up tilt in individuals with paraplegia

Droxidopa: A Review of Its Use in Symptomatic Neurogenic Orthostatic Hypotension

Double-Blinded, Placebo-Controlled Trial Of Midodrine For Exercise Performance Enhancement In Tetraplegia:A Pilot Study

Orthostatic hypotension and cognitive impairment: a dangerous association?

Diurnal Blood Pressure Variation in Quadriplegic Chronic Spinal Cord Injury Patients

Association of hypotension with positive and negative affect and depressive symptoms in the elderly

Treatment for a nondisease: The case of low blood pressure

Pharmacological evidence of alpha1- and alpha2-adrenergic supersensitivity in orthostatic hypotension due to spinal cord injury: a case report

Midodrine for the management of orthostatic hypotension in patients with spinal cord injury: A case report

Effects of Midodrine Hydrochloride on Blood Pressure and Cerebral Blood Flow During Orthostasis in Persons With Chronic Tetraplegia

Home Blood Pressure Is Associated with Depressive Symptoms in an Elderly Population Aged 70 Years and Over: A Population-Based, Cross-Sectional Analysis

Systemic and cerebral hemodynamics during cognitive testing

Both High and Low Blood Pressures Risk Indicators of Death in Middle‐aged Males: Isotonic Regression of Blood Pressure on Age Applied to Data from a 13‐Year Prospective Study

Orthostatic hypotension and orthostatic hypertension in American veterans

Depression and neuropsychological test peformance in acute spinal cord injury patients: Lack of correlation

Partial Angiotensin–Converting Enzyme Inhibition During Acute Orthostatic Stress in Persons With Tetraplegia

Direct and reflexive effects of nitric oxide synthase inhibition on blood pressure

Depressive symptoms in elderly adults with hypotension: Different associations with positive and negative affect

Dissociation between cortical activation and cognitive performance under pharmacological blood pressure elevation in chronic hypotension

Orthostatic Effects of Midodrine Versus L-NAME on Cerebral Blood Flow and the Renin-Angiotensin-Aldosterone System in Tetraplegia

Long-term safety of droxidopa in patients with symptomatic neurogenic orthostatic hypotension

Droxidopa for orthostatic hypotension

Pyridostigmine in autonomic failure: can we treat postural hypotension and bladder dysfunction with one drug?

Low blood pressure associated with low mood: A red herring?

Hemodynamic Effects of l-Threo-3,4-Dihydroxyphenylserine (Droxidopa) in Hypotensive Individuals With Spinal Cord Injury

Orthostatic Responses to Nitric Oxide Synthase Inhibition in Persons With Tetraplegia

Current literature on orthostatic hypotension and training in SCI patients.

iNOS expression in rat aorta is increased after spinal cord transection: A possible cause of orthostatic hypotension in man

Cerebral Blood Flow Responses to Autonomic Dysreflexia in Humans with Spinal Cord Injury

A case of cerebellar hemorrhage secondary to autonomic dysreflexia (AD) in a patient with cervical spinal cord injury

Circadian desynchronization in pulse rate, systolic and diastolic blood pressure, rectal temperature and urine output in traumatic tetraplegics.

Diagnosis and treatment of low blood pressure in a Canadian community.

Effect of L-threo-3,4-dihydroxyphenylserine on orthostatic hypotension in a patient with spinal cord injury.