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Checkpoint Inhibitor and Radiotherapy for Recurrent Gastric Cancer (CIRCUIT)
NCT03453164
PHASE1|PHASE2INTERVENTIONAL
Fukushima Medical University
41 participants
Started 2018-03-28 · Completed 2021-01-31
Status: Completed (as of 12-23-2025)
Conditions
Gastric Cancer
Interventions
Linked Papers (from SciSciNet-V2)
Total Papers4
Background
2Result
0Derived
0Unknown
2Total Citations Per Year
Brief Summary
This study aims to evaluate safety and efficacy of nivolumab (anti-PD-1 antibody), which is approved as tertiary therapy, and neoadjuvant short-term limited local radiotherapy in patients with unresectable recurrent gastric cancer who progressed (intolerance or PD) after standard treatment (primary and secondary chemotherapy) and have more than one lesion assessable in diagnostic imaging (one lesion must be \>=2cm).
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Background Papers4
Radiotherapy-Induced Anti-Tumor Immunity Contributes to the Therapeutic Efficacy of Irradiation and Can Be Augmented by CTLA-4 Blockade in a Mouse Model
2014
115 citations
Radiotherapy-Induced Anti-Tumor Immunity Contributes to the Therapeutic Efficacy of Irradiation and Can Be Augmented by CTLA-4 Blockade in a Mouse Model
2014
115 citations
An abscopal effect in a case of concomitant treatment of locally and peritoneally recurrent gastric cancer using adoptive T‐cell immunotherapy and radiotherapy
2017
28 citations
An abscopal effect in a case of concomitant treatment of locally and peritoneally recurrent gastric cancer using adoptive T‐cell immunotherapy and radiotherapy
2017
28 citations
Result Papers0
No result papers linked
Derived Papers0
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Unknown Papers2
Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial
2017
1,956 citations
Immunogenic Tumor Cell Death Induced by Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma
2012
201 citations