Brain Mechanisms Supporting Meditation-based Analgesia

NCT03414138

NAINTERVENTIONAL

University of California, San Diego

40 participants

Started 2018-04-20 · Completed 2018-08-02

Status: Completed (as of 12-23-2025)

Conditions

Pain

Interventions

BEHAVIORAL: Mindfulness Training BEHAVIORAL: Book Listening Control

Linked Papers (from SciSciNet-V2)

Total Papers57

Background

18

Result

0

Derived

0

Unknown

39

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

Mindfulness meditation has been shown to reduce pain in experimental and clinical settings, and the neural mechanisms underlying this analgesia are distinct from that of placebo related beliefs in the utility of the meditation. Although previous studies have identified potential cortical and sub-cortical targets responsible for mediating these effects, the connectional relationships between them remains largely unexplored. The present study will use blood-oxygen-level dependent (BOLD) neuroimaging to assess functional connections supporting mindfulness meditation.

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Background Papers36

Short-term meditation training improves attention and self-regulation

1,486 citations

Short-term meditation training improves attention and self-regulation

1,486 citations

Tools of the trade: psychophysiological interactions and functional connectivity

Tools of the trade: psychophysiological interactions and functional connectivity

The subjective experience of pain: Where expectations become reality

The subjective experience of pain: Where expectations become reality

Brain Mechanisms Supporting the Modulation of Pain by Mindfulness Meditation

Brain Mechanisms Supporting the Modulation of Pain by Mindfulness Meditation

Neural correlates of interindividual differences in the subjective experience of pain

Neural correlates of interindividual differences in the subjective experience of pain

Mood Influences Supraspinal Pain Processing Separately from Attention

Mood Influences Supraspinal Pain Processing Separately from Attention

Mindfulness Meditation-Based Pain Relief Employs Different Neural Mechanisms Than Placebo and Sham Mindfulness Meditation-Induced Analgesia

Mindfulness Meditation-Based Pain Relief Employs Different Neural Mechanisms Than Placebo and Sham Mindfulness Meditation-Induced Analgesia

Roles of the Insular Cortex in the Modulation of Pain: Insights from Brain Lesions

Roles of the Insular Cortex in the Modulation of Pain: Insights from Brain Lesions

Mindfulness meditation-related pain relief: Evidence for unique brain mechanisms in the regulation of pain

Mindfulness meditation-related pain relief: Evidence for unique brain mechanisms in the regulation of pain

Pain Attenuation through Mindfulness is Associated with Decreased Cognitive Control and Increased Sensory Processing in the Brain

Pain Attenuation through Mindfulness is Associated with Decreased Cognitive Control and Increased Sensory Processing in the Brain

Therapeutic mechanisms of a mindfulness-based treatment for IBS: effects on visceral sensitivity, catastrophizing, and affective processing of pain sensations

Therapeutic mechanisms of a mindfulness-based treatment for IBS: effects on visceral sensitivity, catastrophizing, and affective processing of pain sensations

BOLD signal in insula is differentially related to cardiac function during compassion meditation in experts vs. novices

BOLD signal in insula is differentially related to cardiac function during compassion meditation in experts vs. novices

Differential effects on pain intensity and unpleasantness of two meditation practices.

Differential effects on pain intensity and unpleasantness of two meditation practices.

Breathing‐Based Meditation Decreases Posttraumatic Stress Disorder Symptoms in U.S. Military Veterans: A Randomized Controlled Longitudinal Study

Breathing‐Based Meditation Decreases Posttraumatic Stress Disorder Symptoms in U.S. Military Veterans: A Randomized Controlled Longitudinal Study

Temporal Filtering of Nociceptive Information by Dynamic Activation of Endogenous Pain Modulatory Systems

Mindfulness-Meditation-Based Pain Relief Is Not Mediated by Endogenous Opioids

Mindfulness-Meditation-Based Pain Relief Is Not Mediated by Endogenous Opioids

Temporal Filtering of Nociceptive Information by Dynamic Activation of Endogenous Pain Modulatory Systems

Mindfulness, Acceptance and Catastrophizing in Chronic Pain

Mindfulness, Acceptance and Catastrophizing in Chronic Pain

Brain mechanisms supporting violated expectations of pain

Brain mechanisms supporting violated expectations of pain

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers39

Development and validation of brief measures of positive and negative affect: The PANAS scales.

30,173 citations

An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: Theoretical considerations and preliminary results

3,892 citations

The validation of visual analogue scales as ratio scale measures for chronic and experimental pain

3,619 citations

Psychophysiological and Modulatory Interactions in Neuroimaging

3,055 citations

Temporal Autocorrelation in Univariate Linear Modeling of FMRI Data

2,798 citations

Construct Validity of the Five Facet Mindfulness Questionnaire in Meditating and Nonmeditating Samples

2,597 citations

Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex

2,540 citations

A Three-Dimensional Statistical Analysis for CBF Activation Studies in Human Brain

2,062 citations

Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain

1,961 citations

The clinical use of mindfulness meditation for the self-regulation of chronic pain

1,666 citations

Mindfulness meditation improves cognition: Evidence of brief mental training

1,170 citations

A comparison of pain measurement characteristics of mechanical visual analogue and simple numerical rating scales

1,136 citations

Catastrophizing, pain, and disability in patients with soft-tissue injuries

Retinoic acid delays transcription of human retinal pigment neuroepithelium marker genes in ARPE-19 cells

Sensory-affective relationships among different types of clinical and experimental pain

Cortical thickness and pain sensitivity in zen meditators.

The Effects of Brief Mindfulness Meditation Training on Experimentally Induced Pain

Relation between catastrophizing and depression in chronic pain patients.

Effects of Brief and Sham Mindfulness Meditation on Mood and Cardiovascular Variables

Hemispheric Lateralization of Somatosensory Processing

Low mindfulness predicts pain catastrophizing in a fear-avoidance model of chronic pain

Pain Sensitivity and Analgesic Effects of Mindful States in Zen Meditators: A Cross-Sectional Study

The relation between catastrophizing and the communication of pain experience

A prefrontal non-opioid mechanism in placebo analgesia

Mindful Attention Awareness Scale (MAAS): Psychometric properties of the French translation and exploration of its relations with emotion regulation strategies.

Parietal and cingulate processes in central pain. A combined positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) study of an unusual case

Beck depression inventory in general practice.

Mindfulness, functioning and catastrophizing after multidisciplinary pain management for chronic low back pain

The roles of spatial recruitment and discharge frequency in spinal cord coding of pain: a combined electrophysiological and imaging investigation

The relationship between mindfulness, pain intensity, pain catastrophizing, depression, and quality of life among cancer survivors living with chronic neuropathic pain

Global Cerebral Blood Flow Decreases during Pain

Effects of mindfulness and distraction on pain depend upon individual differences in pain catastrophizing: An experimental study

Pain modulation induced by respiration: Phase and frequency effects

An Investigation of the Associations Between Measures of Mindfulness and Pain Catastrophizing

The absorption scale: A factor-analytic assessment

A Single, Global Patient-Centered Measure from the SF-36 Instrument to Assess Surgical Outcomes and Quality of Life: A Pilot Study