Impact of eHealth-support on Quality of Life in Metastatic Breast Cancer Patients Treated With Palbociclib and Endocrine Therapy

NCT03220178

PHASE4INTERVENTIONAL

Palleos Healthcare GmbH

532 participants

Started 2017-07-24 · Completed 2021-12-07

Status: Terminated (as of 12-23-2025)

Conditions

Breast Neoplasm

Interventions

DRUG: Palbociclib DRUG: Fulvestrant DRUG: Anastrozole DRUG: Letrozole DRUG: Exemestane

Linked Papers (from SciSciNet-V2)

Total Papers20

Background

7

Result

0

Derived

0

Unknown

13

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

In this study the investigators assess the impact of the eHealth-supported therapy management system CANKADO on Quality of Life in patients with HR+, HER2-locally advanced or metastatic breast cancer treated with the cyclin dependent kinase 4/6 (CDK4/6) Inhibitor Palbociclib in combination with an aromatase inhibitor or fulvestrant. Furthermore this approach will be combined with biomarker screening to identify predictive markers for and to learn more about adherence, symptoms, response, and resistance.

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Background Papers14

Patient-reported outcomes: A new era in clinical research

Patient-reported outcomes: A new era in clinical research

Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity

Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity

Antiretroviral dynamics determines HIV evolution and predicts therapy outcome

Antiretroviral dynamics determines HIV evolution and predicts therapy outcome

Communicating uncertainty can lead to less decision satisfaction: a necessary cost of involving patients in shared decision making?

Communicating uncertainty can lead to less decision satisfaction: a necessary cost of involving patients in shared decision making?

eHealth, Participatory Medicine, and Ethical Care: A Focus Group Study of Patients’ and Health Care Providers’ Use of Health-Related Internet Information

eHealth, Participatory Medicine, and Ethical Care: A Focus Group Study of Patients’ and Health Care Providers’ Use of Health-Related Internet Information

White coat hypertension: improving the patient&ndash;health care practitioner relationship

White coat hypertension: improving the patient&ndash;health care practitioner relationship

CDK-Mediated Regulation of Cell Functions via c-Jun Phosphorylation and AP-1 Activation

CDK-Mediated Regulation of Cell Functions via c-Jun Phosphorylation and AP-1 Activation

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers13

Palbociclib and Letrozole in Advanced Breast Cancer

2,306 citations

The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study

1,707 citations

Reliability and validity of the Functional Assessment of Cancer Therapy-Breast quality-of-life instrument.

1,658 citations

How Common Is White Coat Hypertension?

1,187 citations

Health-Related Quality-of-Life Assessments and Patient-Physician Communication

Meaningful change in cancer-specific quality of life scores: differences between improvement and worsening.

Incorporating the Patient's Perspective into Drug Development and Communication: An Ad Hoc Task Force Report of the Patient-Reported Outcomes (PRO) Harmonization Group Meeting at the Food and Drug Administration, February 16, 2001

Recommendations on Evidence Needed to Support Measurement Equivalence between Electronic and Paper-Based Patient-Reported Outcome (PRO) Measures: ISPOR ePRO Good Research Practices Task Force Report

A combination of distribution- and anchor-based approaches determined minimally important differences (MIDs) for four endpoints in a breast cancer scale

Combining Distribution- and Anchor-Based Approaches to Determine Minimally Important Differences

A Pain Monitoring Program for Nurses

New roles for cyclin-dependent kinases in T cell biology: linking cell division and differentiation

Psychosocial aspects of palliative care in advanced cancer