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Preeclampsia Research on Vitamin D, Inflammation, & Depression

NCT03018132

NAINTERVENTIONAL
Cedars-Sinai Medical Center
200 participants
Started 2017-04-01 · Completed 2025-07
Status: Active Not Recruiting (as of 12-23-2025)

Conditions

Pre-EclampsiaDepressionInflammationVitamin D Deficiency

Linked Papers (from SciSciNet-V2)

Total Papers52
Background
18
Result
0
Derived
0
Unknown
34

Total Citations Per Year

Brief Summary

This study is designed to comprehensively investigate the anti-inflammatory role of vitamin D in reproductive aged women, and its association with preeclampsia and depression. Findings will have substantial impact providing new information implicated in the development of preeclampsia (a condition that may include hypertension, tissue swelling caused by excessive fluid, and kidney stress) and postpartum depression (after birth). Additionally, the study is designed to understand how early mental health screening and evaluation can help pregnant women reduce their risk of developing postpartum depression. Testing the acceptability and effectiveness of this mental health screening, education and referral program at Cedars-Sinai Medical Center will provide valuable patient centered qualitative and quantitative data that can be used in future services planning. The study will enroll up to 200 pregnant women (in third trimester of pregnancy) in total.

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Background Papers36

From inflammation to sickness and depression: when the immune system subjugates the brain
2007
6,294 citations
From inflammation to sickness and depression: when the immune system subjugates the brain
2007
6,294 citations
The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know
2010
3,789 citations
The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know
2010
3,789 citations
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
2009
3,395 citations
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
2009
3,395 citations
A Meta-analysis of Depression During Pregnancy and the Risk of Preterm Birth, Low Birth Weight, and Intrauterine Growth Restriction
2010
1,708 citations
A Meta-analysis of Depression During Pregnancy and the Risk of Preterm Birth, Low Birth Weight, and Intrauterine Growth Restriction
2010
1,708 citations
Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials
2014
891 citations
Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials
2014
891 citations
Validation of a brief measure of anxiety-related severity and impairment: The Overall Anxiety Severity and Impairment Scale (OASIS)
2008
332 citations
Validation of a brief measure of anxiety-related severity and impairment: The Overall Anxiety Severity and Impairment Scale (OASIS)
2008
332 citations
Prenatal Depression and Adverse Birth Outcomes: An Updated Systematic Review
2014
277 citations
Prenatal Depression and Adverse Birth Outcomes: An Updated Systematic Review
2014
277 citations
Vitamin D insufficiency in pregnant and nonpregnant women of childbearing age in the United States
2010
238 citations
Vitamin D insufficiency in pregnant and nonpregnant women of childbearing age in the United States
2010
238 citations
Perinatal depression—The fourth inflammatory morbidity of pregnancy?
2013
206 citations
Perinatal depression—The fourth inflammatory morbidity of pregnancy?
2013
206 citations
Depressive symptoms are associated with elevated serum proinflammatory cytokines among pregnant women
2009
195 citations
Depressive symptoms are associated with elevated serum proinflammatory cytokines among pregnant women
2009
195 citations
Psychoneuroimmunology in pregnancy: Immune pathways linking stress with maternal health, adverse birth outcomes, and fetal development
2011
172 citations
Psychoneuroimmunology in pregnancy: Immune pathways linking stress with maternal health, adverse birth outcomes, and fetal development
2011
172 citations
Early-Pregnancy Vitamin D Deficiency and Risk of Preterm Birth Subtypes
2015
145 citations
Depression during pregnancy: a risk factor for adverse neonatal outcomes? A critical review of the literature
2013
145 citations
Early-Pregnancy Vitamin D Deficiency and Risk of Preterm Birth Subtypes
2015
145 citations
Depression during pregnancy: a risk factor for adverse neonatal outcomes? A critical review of the literature
2013
145 citations
Antenatal Depressive Symptoms and the Risk of Preeclampsia or Operative Deliveries: A Meta-Analysis
2015
115 citations
Antenatal Depressive Symptoms and the Risk of Preeclampsia or Operative Deliveries: A Meta-Analysis
2015
115 citations
A survey of the clinical acceptability of screening for postnatal depression in depressed and non-depressed women
2006
94 citations
A survey of the clinical acceptability of screening for postnatal depression in depressed and non-depressed women
2006
94 citations
The relationship between severe maternal morbidity and psychological health symptoms at 6–8 weeks postpartum: a prospective cohort study in one English maternity unit
2014
68 citations
The relationship between severe maternal morbidity and psychological health symptoms at 6–8 weeks postpartum: a prospective cohort study in one English maternity unit
2014
68 citations
Lower prenatal vitamin D status and postpartum depressive symptomatology in African American women: Preliminary evidence for moderation by inflammatory cytokines
2015
64 citations
Lower prenatal vitamin D status and postpartum depressive symptomatology in African American women: Preliminary evidence for moderation by inflammatory cytokines
2015
64 citations
Vitamin D Elicits Anti-Inflammatory Response, Inhibits Contractile-Associated Proteins, and Modulates Toll-Like Receptors in Human Myometrial Cells
2012
63 citations
Vitamin D Elicits Anti-Inflammatory Response, Inhibits Contractile-Associated Proteins, and Modulates Toll-Like Receptors in Human Myometrial Cells
2012
63 citations

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers34

Detection of Postnatal Depression
1987
11,990 citations
Impact of Event Scale: A Measure of Subjective Stress
1979
7,783 citations
The Structured Clinical Interview for DSM-III-R (SCID)
1992
4,294 citations
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
2006
3,773 citations
Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis
2009
2,576 citations
Screening for Depression in Adults
2016
1,262 citations
Inter‐rater reliability of the Structured Clinical Interview for DSM‐IV Axis I Disorders (SCID I) and Axis II Disorders (SCID II)
2010
1,068 citations
Impact of Disseminating Quality Improvement Programs for Depression in Managed Primary Care
2000
1,040 citations
Vitamin D deficiency and depression in adults: systematic review and meta-analysis
2013
714 citations
Depression Is Associated With Decreased 25-Hydroxyvitamin D and Increased Parathyroid Hormone Levels in Older Adults
2008
444 citations
The Lifetime History of Major Depression in Women
1993
325 citations
Postpartum Depression Beyond the Early Postpartum Period
2004
272 citations
Prevalence and correlates of major depressive episode in pregnant and postpartum women in the United States
2011
251 citations
Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression
2007
246 citations
Untreated prenatal maternal depression and the potential risks to offspring: a review
2012
245 citations
Epidemiology of depression throughout the female life cycle.
2002
242 citations
Vitamin D and Pre-Eclampsia: Original Data, Systematic Review and Meta-Analysis
2013
176 citations
Posttraumatic Stress Disorder in New Mothers: Results from a Two-Stage U.S. National Survey
2011
171 citations
Routine screening for postpartum depression.
2001
170 citations
Severe preeclampsia goes along with a cytokine network disturbance towards a systemic inflammatory state
2013
115 citations
Depression screening and patient outcomes in pregnancy or postpartum: A systematic review
2014
112 citations
Marcé International Society position statement on psychosocial assessment and depression screening in perinatal women
2013
106 citations
An Exploratory Study of Postpartum Depression and Vitamin D
2010
76 citations
Women's mental health nursing: depression, anxiety and stress during pregnancy
2010
69 citations
The increased maternal serum levels of IL-6 are associated with the severity and onset of preeclampsia
2012
65 citations
Vitamin D Nutritional Status and Antenatal Depressive Symptoms in African American Women
2012
64 citations
Incidence of postpartum depression in Olmsted County, Minnesota. A population-based, retrospective study.
1999
56 citations
Association between serum 25‐hydroxyvitamin D levels measured 24 hours after delivery and postpartum depression
2014
53 citations
Association of Antenatal Depression Symptoms and Antidepressant Treatment With Preterm Birth
2016
46 citations
Preferences for Mental Health Screening Among Pregnant Women
2015
32 citations
Care for Postpartum Depression: What Do Women and Their Partners Prefer?
2015
30 citations
Early pregnancy vitamin D and patterns of antenatal inflammation in African–American women
2014
21 citations
Depression Management by NICU Nurses
2015
10 citations
Untitled
— citations