Subthalamic Stimulation in Tourette's Syndrome

NCT02619084

PHASE2INTERVENTIONAL

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

10 participants

Started 2011-12 · Completed 2015-12

Status: Completed (as of 12-23-2025)

Conditions

Tourette's SyndromeTourette SyndromeGilles de la Tourette SyndromeTourette Disorder

Interventions

PROCEDURE: STN DBS

Linked Papers (from SciSciNet-V2)

Total Papers43

Background

8

Result

0

Derived

0

Unknown

35

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

The main objective of this project is to evaluate the efficacy of subthalamic nucleus deep brain stimulation (STN DBS) in treating motor and phonic tics in medically refractory Tourette's syndrome (TS). Secondary objectives are to individuate and standardize the best electrical parameters for STN stimulation in TS, to evaluate the efficacy and safety on non-motor TS features, such as behavioral abnormalities and psychiatric disorders, during chronic STN stimulation, to correlate the improvement of TS motor and non-motor symptoms to the modification in brain activity recorded by PET study and to explore the pathophysiology of TS, and to evaluate the safety of STN DBS in TS patients.

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Background Papers16

Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behavior

Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behavior

Tourette's syndrome and deep brain stimulation

Tourette's syndrome and deep brain stimulation

Contemporary assessment and pharmacotherapy of Tourette syndrome

Contemporary assessment and pharmacotherapy of Tourette syndrome

Deep Brain Stimulation in Tourette’s Syndrome

Deep Brain Stimulation in Tourette’s Syndrome

IMPROVEMENT OF TICS AFTER SUBTHALAMIC NUCLEUS DEEP BRAIN STIMULATION

IMPROVEMENT OF TICS AFTER SUBTHALAMIC NUCLEUS DEEP BRAIN STIMULATION

Tourette syndrome and obsessive–compulsive disorder

Tourette syndrome and obsessive–compulsive disorder

The treatment of Gilles de la Tourette syndrome by limbic leucotomy.

The treatment of Gilles de la Tourette syndrome by limbic leucotomy.

High-Frequency Stimulation of the Anterior Subthalamic Nucleus Reduces Stereotyped Behaviors in Primates

High-Frequency Stimulation of the Anterior Subthalamic Nucleus Reduces Stereotyped Behaviors in Primates

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers35

Subthalamic Nucleus Stimulation in Severe Obsessive–Compulsive Disorder

Tourette's Syndrome

Neural correlates of tic generation in Tourette syndrome: an event-related functional MRI study

The prevalence and epidemiology of Gilles de la Tourette syndrome

Deep brain stimulation in 18 patients with severe Gilles de la Tourette syndrome refractory to treatment: the surgery and stimulation

Chronic bilateral thalamic stimulation: a new therapeutic approach in intractable Tourette syndrome

Pathological gambling in Parkinson's disease improves on chronic subthalamic nucleus stimulation

Internal Pallidal and Thalamic Stimulation in Patients With Tourette Syndrome

Tourette's syndrome: from behaviour to biology

Prevalence of tics in schoolchildren and association with placement in special education

Phenomenology of tics and natural history of tic disorders

Patient selection and assessment recommendations for deep brain stimulation in Tourette syndrome

GPi deep brain stimulation for Tourette syndrome improves tics and psychiatric comorbidities

Deep Brain Stimulation of the Anterior Internal Capsule for the Treatment of Tourette Syndrome: Technical Case Report

Efficient internal pallidal stimulation in Gilles de la Tourette syndrome: A case report

Deep brain stimulation in Tourette's syndrome: Two targets?

[Stereotaxic treatment of tics and inarticulate cries or coprolalia considered as motor obsessional phenomena in Gilles de la Tourette's disease].

Subthalamic Stimulation in Parkinson Disease

Therapy‐refractory tourette syndrome: Beneficial outcome with globus pallidus internus deep brain stimulation

Deep Brain Stimulation in Movement and Psychiatric Disorders

Functional neurosurgery for movement disorders: a historical perspective

Lack of benefit of accumbens/capsular deep brain stimulation in a patient with both tics and obsessive–compulsive disorder

Hemi tics and deep brain stimulation

Deep brain stimulation of the right nucleus accumbens in a patient with Tourette syndrome. Case report.

Hassler and Dieckmann's seminal paper on stereotactic thalamotomy for Gilles de la Tourette syndrome: Translation and critical reappraisal

Dysfunction of the subthalamic nucleus induces behavioral and movement disorders in monkeys

Emerging drugs in Tourette syndrome

DBS in Tourette syndrome: rationale, current status and future prospects

Stereotactic Surgery in Gilles de la Tourette Syndrome

The clinical spectrum of motor tics.