Monocentric Trial: Stem Cell Emergency Life Threatening Limbs Arteriopathy (SCELTA)

NCT02454231

PHASE2|PHASE3INTERVENTIONAL

University of Florence

45 participants

Started 2009-09 · Completed 2015-10

Status: Completed (as of 12-23-2025)

Conditions

Critical Limb Ischemia

Interventions

BIOLOGICAL: Transplantation of circulating CD14+CD34+cells BIOLOGICAL: Transplantation of BM MNC

Linked Papers (from SciSciNet-V2)

Total Papers19

Background

1

Result

0

Derived

0

Unknown

18

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

The investigators designed a randomized clinical trial (stem cell emergency life threatening arteriopathy or SCELTA) to compare the therapeutic efficacy of the auto-transplant of enriched circulating EPCs (ECEPCs) with auto-transplant of BM-MNCs. ECEPCs, obtained by immunoselection of CD14+ and CD34+ cells, or BM-MNCs, were injected intramuscularly in the affected limb of patients with critical limb ischemia (CLI).

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Background Papers2

Transplantation ofex vivoexpanded endothelial progenitor cells for therapeutic neovascularization

1,869 citations

Transplantation ofex vivoexpanded endothelial progenitor cells for therapeutic neovascularization

1,869 citations

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers18

Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells

3,230 citations

The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells

3,179 citations

Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial

1,724 citations

Diagnosis and Treatment of Chronic Arterial Insufficiency of the Lower Extremities: A Critical Review

Oct‐4 : Gatekeeper in the Beginnings of Mammalian Development

Prevalence of Lower-Extremity Disease in the U.S. Adult Population ≥40 Years of Age With and Without Diabetes

Endothelial Progenitor Cell Vascular Endothelial Growth Factor Gene Transfer for Vascular Regeneration

Enhanced Self-Renewal of Hematopoietic Stem Cells Mediated by the Polycomb Gene Product Bmi-1

Determinants of Peripheral Arterial Disease in the Elderly

CD14+CD34 ^low Cells With Stem Cell Phenotypic and Functional Features Are the Major Source of Circulating Endothelial Progenitors

Therapeutic Potential of Endothelial Progenitor Cells in Cardiovascular Diseases

Post-natal endothelial progenitor cells for neovascularization in tissue regeneration

Peripheral Artery Disease and Cardiovascular Risk Factors in the Elderly

Autologous Bone Marrow Implantation Induced Angiogenesis and Improved Deteriorated Exercise Capacity in a Rat Ischemic Hindlimb Model

False aneurysm of the left ventricular apex after a silent anterior myocardial infarction.

[Value of measuring transcutaneous oxygen pressure in arterial disease of the legs].

[Percutaneous treatment of peripheral obstructive arteriopathy: the reasons for a choice].