A 6 Month, Open-Label, Pilot Futility Clinical Trial of Oral Salsalate for Progressive Supranuclear Palsy

NCT02422485

PHASE1INTERVENTIONAL

Adam Boxer

10 participants

Started 2015-04 · Completed 2019-12

Status: Completed (as of 12-23-2025)

Conditions

Progressive Supranuclear Palsy

Interventions

DRUG: Salsalate

Linked Papers (from SciSciNet-V2)

Total Papers25

Background

14

Result

0

Derived

0

Unknown

11

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

This is a multi-center, open label, pilot futility clinical trial of the safety, tolerability, pharmacodynamics and preliminary efficacy of oral salsalate in up to 10 patients with PSP.

Sort by:

Background Papers27

The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

16,302 citations

The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

16,302 citations

Cognitive Stimulation in Patients with Dementia: Randomized Controlled Trial

3,343 citations

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

The acetylation of tau inhibits its function and promotes pathological tau aggregation

The acetylation of tau inhibits its function and promotes pathological tau aggregation

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

Development of methodology for conducting clinical trials in frontotemporal lobar degeneration

Development of methodology for conducting clinical trials in frontotemporal lobar degeneration

Sleep and Circadian Rhythm Regulation in Early Parkinson Disease

Sleep and Circadian Rhythm Regulation in Early Parkinson Disease

Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: The NNIPPS Study

Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: The NNIPPS Study

Natural history and survival of 14 patients with corticobasal degeneration confirmed at postmortem examination

Natural history and survival of 14 patients with corticobasal degeneration confirmed at postmortem examination

Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial

Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial

Salicylate (Salsalate) in Patients With Type 2 Diabetes

Salicylate (Salsalate) in Patients With Type 2 Diabetes

Comparison of Analytical Platforms for Cerebrospinal Fluid Measures of β-Amyloid 1-42, Total tau, and P-tau₁₈₁ for Identifying Alzheimer Disease Amyloid Plaque Pathology

Comparison of Analytical Platforms for Cerebrospinal Fluid Measures of β-Amyloid 1-42, Total tau, and P-tau₁₈₁ for Identifying Alzheimer Disease Amyloid Plaque Pathology

Therapeutic strategies for tau mediated neurodegeneration

Therapeutic strategies for tau mediated neurodegeneration

Intrinsic connectivity network disruption in progressive supranuclear palsy

Intrinsic connectivity network disruption in progressive supranuclear palsy

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers11

Development and validation of a geriatric depression screening scale: A preliminary report

14,099 citations

Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome)

2,426 citations

The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): Preliminary Clinical Validity

2,199 citations

Progressive Supranuclear Palsy

1,864 citations

Validity and Reliability of the Alzheimerʼs Disease Cooperative Study-Clinical Global Impression of Change

Prevalence of progressive supranuclear palsy and multiple system atrophy: a cross-sectional study

A clinical rating scale for progressive supranuclear palsy

Accuracy of clinical criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome)

Prevalence and natural history of progressive supranuclear palsy

Equivalence of the Color Trails Test and Trail Making Test in Nonnative English-Speakers

Measuring quality of life in PSP