Host Genetic Susceptibility to Avian Influenza A/H5N1

NCT01074736

NULLOBSERVATIONAL

South East Asia Infectious Disease Clinical Research Network

500 participants

Started 2008-07 · Completed 2010-10

Status: Completed (as of 12-23-2025)

Conditions

Influenza A Virus/H5N1 Subtype

Interventions

Linked Papers (from SciSciNet-V2)

Total Papers55

Background

18

Result

0

Derived

0

Unknown

37

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

The identification and characterization of susceptibility loci for H5N1 infection in humans could have profound implications. The detection of host genetic factors may shed light on key pathogenic interactions between H5N1 and human cells, assisting in identifying the viral characteristics determining pandemic potential. In addition, the identification and verification of susceptibility loci would be followed by functional studies which might point the way to new therapeutic and preventive options. The objective of this study is to investigate if host genetic factors are associated with susceptibility to influenza H5N1 illness

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Background Papers36

Human and avian influenza viruses target different cell types in cultures of human airway epithelium

Human and avian influenza viruses target different cell types in cultures of human airway epithelium

Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus

Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus

Role of Host Cytokine Responses in the Pathogenesis of Avian H5N1 Influenza Viruses in Mice

Role of Host Cytokine Responses in the Pathogenesis of Avian H5N1 Influenza Viruses in Mice

Influenza A Virus (H5N1) Infection in Cats Causes Systemic Disease with Potential Novel Routes of Virus Spread within and between Hosts

Influenza A Virus (H5N1) Infection in Cats Causes Systemic Disease with Potential Novel Routes of Virus Spread within and between Hosts

Mannose-Binding Lectin in Severe Acute Respiratory Syndrome Coronavirus Infection

Mannose-Binding Lectin in Severe Acute Respiratory Syndrome Coronavirus Infection

Probable Tiger-to-Tiger Transmission of Avian Influenza H5N1

Probable Tiger-to-Tiger Transmission of Avian Influenza H5N1

Genetic susceptibility to infectious diseases: big is beautiful, but will bigger be even better?

Genetic susceptibility to infectious diseases: big is beautiful, but will bigger be even better?

Receptor binding specificity of recent human H3N2 influenza viruses

Receptor binding specificity of recent human H3N2 influenza viruses

Inefficient Transmission of H5N1 Influenza Viruses in a Ferret Contact Model

Inefficient Transmission of H5N1 Influenza Viruses in a Ferret Contact Model

Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection

Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection

Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population

Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population

Low Frequency of Poultry-to-Human H5N1 Transmission, Southern Cambodia, 2005

Low Frequency of Poultry-to-Human H5N1 Transmission, Southern Cambodia, 2005

Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes: a case-control study

Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes: a case-control study

Lack of H5N1 Avian Influenza Transmission to Hospital Employees, Hanoi, 2004

Lack of H5N1 Avian Influenza Transmission to Hospital Employees, Hanoi, 2004

Interaction Between Humans and Poultry, Rural Cambodia

Interaction Between Humans and Poultry, Rural Cambodia

Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data

Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers37

Principal components analysis corrects for stratification in genome-wide association studies

9,771 citations

Influenza virus receptors in the human airway

1,329 citations

Avian Influenza A (H5N1) Infection in Humans

1,274 citations

Problems of reporting genetic associations with complex outcomes

1,221 citations

A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection

1,174 citations

Probable Person-to-Person Transmission of Avian Influenza A (H5N1)

Avian Influenza A (H5N1) in 10 Patients in Vietnam

Transmission of H7N7 avian influenza A virus to human beings during a large outbreak in commercial poultry farms in the Netherlands

H5N1 Virus Attachment to Lower Respiratory Tract

Host Species Barriers to Influenza Virus Infections

Association of variants of the gene for mannose-binding lectin with susceptibility to meningococcal disease

Three Indonesian Clusters of H5N1 Virus Infection in 2005

Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract

Genetic Susceptibility to Respiratory Syncytial Virus Bronchiolitis Is Predominantly Associated with Innate Immune Genes

Key concepts in genetic epidemiology

Aspects of Genetic Susceptibility to Human Infectious Diseases

Antibody Response in Individuals Infected with Avian Influenza A (H5N1) Viruses and Detection of Anti‐H5 Antibody among Household and Social Contacts

Quantitative Analysis of the Bidirectional Fetomaternal Transfer of Nucleated Cells and Plasma DNA

Risk of Influenza A (H5N1) Infection among Health Care Workers Exposed to Patients with Influenza A (H5N1), Hong Kong

Avian Influenza A (H5N1) Infection in Eastern Turkey in 2006

Association of Severe Respiratory Syncytial Virus Bronchiolitis with Interleukin‐4 and Interleukin‐4 Receptor α Polymorphisms

Human-specific Regulation of α2–6-linked Sialic Acids

Epidemiology of Cases of H5N1 Virus Infection in Indonesia, July 2005–June 2006

Dynamic patterns of avian and human influenza in east and southeast Asia

Familial Properdin Deficiency and Fatal Meningococcemia

Evidence for a Heritable Predisposition to Death Due to Influenza

Duffy blood group and malaria

Two clusters of human infection with influenza A/H5N1 virus in the Republic of Azerbaijan, February–March 2006

Factor H, a regulator of complement activity, is a major determinant of meningococcal disease susceptibility in UK Caucasian patients

Effective replication of human influenza viruses in mice lacking a major α2,6 sialyltransferase

Lack of Evidence of Avian‐to‐Human Transmission of Avian Influenza A (H5N1) Virus among Poultry Workers, Kano, Nigeria, 2006

Is Exposure to Sick or Dead Poultry Associated With Flulike Illness?

Seroprevalence of Anti-H5 Antibody among Thai Health Care Workers after Exposure to Avian Influenza (H5N1) in a Tertiary Care Center

Inhibition of influenza viral neuraminidase activity by collectins

Detection of maternal deoxyribonucleic acid in umbilical cord plasma by using fluorescent polymerase chain reaction amplification of short tandem repeat sequences

Human Genetic Polymorphisms Affecting HIV-1 Diseases