Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence

NCT00749658

PHASE2|PHASE3INTERVENTIONAL

University of Minnesota

121 participants

Started 2008-11 · Completed 2010-09

Status: Completed (as of 12-23-2025)

Conditions

Nicotine DependenceNicotine Withdrawal

Interventions

DRUG: Bupropion DRUG: Varenicline

Linked Papers (from SciSciNet-V2)

Total Papers34

Background

2

Result

0

Derived

0

Unknown

32

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

The objective of this proposal is to elucidate effects of bupropion SR + varenicline on smoking-cessation related processes in early abstinence using a human laboratory model. A within-subjects design will be used to assess the additive effects of bupropion and varenicline in 48 treatment seeking smokers \[bupropion SR (300 mg/day)+placebo, varenicline (2 mg/day+placebo, and bupropion SR (300 mg/day)+varenicline (2 mg/day)\]. Outcomes include withdrawal and craving, cognition, stress tolerance, anxiety, the reinforcing effects of smoking, and smoking topography. Hypotheses: We hypothesize that greatest treatment effects will be observed in the bupropion SR+varenicline group followed by varenicline+placebo and bupropion SR+placebo groups.

Sort by:

Background Papers4

Efficacy of bupropion alone and in combination with nicotine gum

Efficacy of bupropion alone and in combination with nicotine gum

Combination Treatment for Nicotine Dependence: State of the Science

Combination Treatment for Nicotine Dependence: State of the Science

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers32

The Fagerström Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire

10,143 citations

Biochemical verification of tobacco use and cessation

1,760 citations

A Controlled Trial of Sustained-Release Bupropion, a Nicotine Patch, or Both for Smoking Cessation

1,635 citations

Efficacy of Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Placebo or Sustained-Release Bupropion for Smoking Cessation<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

1,630 citations

Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Sustained-Release Bupropion and Placebo for Smoking Cessation<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

1,343 citations

Measures of abstinence in clinical trials: issues and recommendations

1,037 citations

Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation

Bupropion: a review of its mechanism of antidepressant activity.

Smoking Cessation With Varenicline, a Selective α4β2 Nicotinic Receptor Partial Agonist

The effect of bupropion on nicotine craving and withdrawal

Combined Use of Nicotine Patch and Gum in Smoking Cessation: A Placebo-Controlled Clinical Trial

A 12-Week Double-Blind, Placebo-Controlled Study of Bupropion SR Added to High-Dose Dual Nicotine Replacement Therapy for Smoking Cessation or Reduction in Schizophrenia

Nicotine-mecamylamine treatment for smoking cessation: The role of pre-cessation therapy.

Extended Nortriptyline and Psychological Treatment for Cigarette Smoking

Nicotine Inhaler and Nicotine Patch as a Combination Therapy for Smoking Cessation

Randomized Clinical Trial of the Efficacy of Bupropion Combined With Nicotine Patch in the Treatment of Adolescent Smokers.

Combination Nicotine Replacement Therapy for Smoking Cessation

A Controlled Trial of Naltrexone Augmentation of Nicotine Replacement Therapy for Smoking Cessation

How does bupropion work as a smoking cessation aid?

Behavioral and biochemical investigations of bupropion metabolites

Nicotine patch and paroxetine for smoking cessation.

Pharmacokinetic Optimisation of Sustained-Release Bupropion for Smoking Cessation

Naltrexone and nicotine patch in smoking cessation: A preliminary study

A randomized controlled trial of oral selegiline plus nicotine skin patch compared with placebo plus nicotine skin patch for smoking cessation

Comparison of nicotine patch alone versus nicotine nasal spray alone versus a combination for treating smokers: A minimal intervention, randomized multicenter trial in a nonspecialized setting

Randomized Comparison of a Nicotine Inhaler and Bupropion for Smoking Cessation and Relapse Prevention

Bupropion for the treatment of nicotine withdrawal and craving

Combined effects of venlafaxine, nicotine replacement, and brief counseling on smoking cessation.

Concurrent agonist-antagonist administration for the analysis and treatment of drug dependence

Effect of bupropion on physiological measures of stress in smokers during nicotine withdrawal

Naltrexone‐Bupropion Combination Therapy for Protracted Abstinence Dysphoria

Nicotine chewing gum and nicotine patch.