Lactulose Supplementation in Premature Infants

NCT00616876

PHASE2INTERVENTIONAL

Bnai Zion Medical Center

28 participants

Started 2005-02 · Completed 2007-01

Status: Completed (as of 12-23-2025)

Conditions

Necrotizing EnterocolitisSepsis

Interventions

DRUG: Lactulose DIETARY_SUPPLEMENT: Dextrose

Linked Papers (from SciSciNet-V2)

Total Papers39

Background

7

Result

0

Derived

0

Unknown

32

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

A pilot study to test the safety of use of lactulose in preterm infants and to preliminary assess the hypothesis that lactulose would support the early growth of Lactobacilli in the stools of premature infants and possibly would also improve nutritional status and decrease NEC and late-onset sepsis.

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Background Papers14

A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age

A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age

Supplementation of a bovine milk formula with an oligosaccharide mixture increases counts of faecal bifidobacteria in preterm infants

Supplementation of a bovine milk formula with an oligosaccharide mixture increases counts of faecal bifidobacteria in preterm infants

Stool microflora in extremely low birthweight infants

Stool microflora in extremely low birthweight infants

Early administration of Bifidobacterium breve to preterm infants: randomised controlled trial

Early administration of Bifidobacterium breve to preterm infants: randomised controlled trial

Enteral feeding of premature infants with Lactobacillus GG.

Enteral feeding of premature infants with Lactobacillus GG.

Factors influencing the presence of faecal lactobacilli in early infancy.

Factors influencing the presence of faecal lactobacilli in early infancy.

Probiotics for preterm infants?

Probiotics for preterm infants?

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers32

Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics

7,436 citations

Gut flora in health and disease

3,233 citations

Demonstration of safety of probiotics — a review

Oral Probiotics Reduce the Incidence and Severity of Necrotizing Enterocolitis in Very Low Birth Weight Infants

Review article: prebiotics in the gastrointestinal tract

Oral Probiotics Prevent Necrotizing Enterocolitis in Very Low Birth Weight Neonates

Dosage-Related Bifidogenic Effects of Galacto- and Fructooligosaccharides in Formula-Fed Term Infants

The Intestinal Microflora of Infants: Composition of Fecal Flora in Breast-Fed and Bottle-Fed Infants

Probiotics Feeding in Prevention of Urinary Tract Infection, Bacterial Sepsis and Necrotizing Enterocolitis in Preterm Infants

Nosocomial infections among neonates in high-risk nurseries in the United States. National Nosocomial Infections Surveillance System.

Colon Microflora in Infants Fed Formula with Galacto- and Fructo-Oligosaccharides: More Like Breast-Fed Infants

Reduced incidence of necrotizing enterocolitis associated with enteral administration of Lactobacillus acidophilus and Bifidobacterium infantis to neonates in an intensive care unit

The development of the bacterial flora in normal neonates

Probiotics for prevention of necrotising enterocolitis in preterm neonates with very low birthweight: a systematic review of randomised controlled trials

Development of the intestinal flora in very low birth weight infants compared to normal full-term newborns

Enteral feeding of premature infants with Saccharomyces boulardii

Medical, nutritional and technological properties of lactulose. An update

Increase of faecal bifidobacteria due to dietary oligosaccharides induces a reduction of clinically relevant pathogen germs in the faeces of formula-fed preterm infants

Fecal bacterial microflora of newborn infants during intensive care management and treatment with five antibiotic regimens

The Developing Intestinal Ecosystem: Implications for the Neonate

Effects of Oral Lactobacillus GG on Enteric Microflora in Low-Birth-Weight Neonates

Prebiotic Oligosaccharides in Dietetic Products for Infants: A Commentary by the ESPGHAN Committee on Nutrition

Prebiotic oligosaccharides reduce stool viscosity and accelerate gastrointestinal transport in preterm infants

Bifidusflora bei Flaschenkindern durch bifidogene Substanzen (Bifidusfaktor)

Neonatal Necrotizing Enterocolitis: Possible Role of Probiotic Supplementation

Redefining Lactose as a Conditional Prebiotic

Use of Lactulose to Create a Preponderance of Lactobacilli in the Intestine of Bottle-Fed Infants

Probiotics in Pediatrics

Oligosaccharides might stimulate calcium absorption in formula‐fed preterm infants

[Effects of oral administration of bifidobacteria on intestinal microflora in premature and newborn infants].