Soy, Selenium and Breast Cancer Risk

NCT00555386

NAINTERVENTIONAL

University of East Anglia

27 participants

Started 2007-04 · Completed 2008-08

Status: Completed (as of 12-23-2025)

Conditions

Breast Cancer Risk

Interventions

DIETARY_SUPPLEMENT: Soy and Selenium

Linked Papers (from SciSciNet-V2)

Total Papers32

Background

1

Result

0

Derived

0

Unknown

31

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

There is evidence to suggest that some dietary components can reduce the risk of breast cancer. In this pilot study two such components, isoflavones (compounds found in soy products) and selenium, will be given to women classed as at moderate to high risk of the disease. The aim is to determine some novel biomarkers of risk and to see the effect of supplementation on them.

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Background Papers2

BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells

BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers31

Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.

10,659 citations

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

3,602 citations

Estrogen and the Risk of Breast Cancer

1,081 citations

Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women

Lessons from Basic Research in Selenium and Cancer Prevention

Selenium and its relationship to cancer: an update

Meta-Analysis of Soy Intake and Breast Cancer Risk

Soy for Breast Cancer Survivors: A Critical Review of the Literature

Detection of epithelial ovarian cancer using ¹H‐NMR‐based metabonomics

Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium.

Biological effects of isoflavones in young women: importance of the chemical composition of soyabean products

Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases

Application of biofluid 1H nuclear magnetic resonance-based metabonomic techniques for the analysis of the biochemical effects of dietary isoflavones on human plasma profile

Premenopausal equol excretors show plasma hormone profiles associated with lowered risk of breast cancer.

Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women.

Independent Validation of Candidate Breast Cancer Serum Biomarkers Identified by Mass Spectrometry

Selenium and Mortality in the Elderly: Results from the EVA Study

Mechanisms of mammary cancer chemoprevention by organoselenium compounds

Soy Isoflavones Exert Modest Hormonal Effects in Premenopausal Women1

IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC)

Biofluid 1H NMR-based metabonomic techniques in nutrition research — metabolic effects of dietary isoflavones in humans

Selenium and Cancer Chemoprevention: Hypotheses Integrating the Actions of Selenoproteins and Selenium Metabolites in Epithelial and Non-Epithelial Target Cells

Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation

2Phytoestrogens and breast cancer

The initiation of breast and prostate cancer

Soy isoflavone genistein modulates cell cycle progression and induces apoptosis in HER-2/neu oncogene expressing human breast epithelial cells

Selenium Disrupts Estrogen Signaling by Altering Estrogen Receptor Expression and Ligand Binding in Human Breast Cancer Cells

Selenium disrupts estrogen receptor α signaling and potentiates tamoxifen antagonism in endometrial cancer cells and tamoxifen-resistant breast cancer cells

Dietary Factors Modifying Breast Cancer Risk and Relation to Time of Intake

A Comparative Study of Growth-Inhibitory Effects of Isoflavones and Their Metabolites on Human Breast and Prostate Cancer Cell Lines

Analysis and classification of proton NMR spectra of lipoprotein fractions from healthy volunteers and patients with cancer or CHD.