The Cytoskeleton During Early Development: Structural Transformation and Reorganization of RNA and Protein

Gene Activity in Early Development

1968 • 1,725 citations

A major developmental transition in early xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage

1982 • 1,635 citations

A maternal mRNA localized to the vegetal hemisphere in xenopus eggs codes for a growth factor related to TGF-β

1987 • 747 citations

Evolution and Development

1982 • 729 citations

Intracellular localization of messenger RNAs for cytoskeletal proteins

1986 • 639 citations

Epithelial cytoskeletal framework and nuclear matrix-intermediate filament scaffold: three-dimensional organization and protein composition.

1984 • 545 citations

Generation of asymmetry and segregation of germ-line granules in early C. elegans embryos

1983 • 534 citations

A cytoskeletal structure with associated polyribosomes obtained from HeLa cells

1977 • 530 citations

Organization, Chemistry, and Assembly of the Cytoskeletal Apparatus of the Intestinal Brush Border

1985 • 525 citations

Movement of myosin-coated fluorescent beads on actin cables in vitro

1983 • 502 citations

Translocation and clustering of endosomes and lysosomes depends on microtubules.

1987 • 498 citations

Identification and cloning of localized maternal RNAs from xenopus eggs

1985 • 464 citations

Membrane-cytoskeleton interaction

1983 • 389 citations

Microtubule configurations during fertilization, mitosis, and early development in the mouse and the requirement for egg microtubule-mediated motility during mammalian fertilization.

1985 • 364 citations

Single microtubules from squid axoplasm support bidirectional movement of organelles

1985 • 363 citations

Organization of the cytoskeleton in early Drosophila embryos.

1986 • 352 citations

Translocation of a localized maternal mRNA to the vegetal pole of Xenopus oocytes

1987 • 346 citations

Organelle, bead, and microtubule translocations promoted by soluble factors from the squid giant axon

1985 • 346 citations

Behavior of centrosomes during fertilization and cell division in mouse oocytes and in sea urchin eggs.

1986 • 330 citations

Formation of cytoskeletal elements during mouse embryogenesis. IV. Ultrastructure of primary mesenchymal cells and their cell-cell interactions.

1983 • 320 citations

The Directed Migration of Eukaryotic Cells

1986 • 312 citations

Cytoplasmic microtubules in normal and transformed cells in culture: analysis by tubulin antibody immunofluorescence.

1975 • 307 citations

Movement of organelles along filaments dissociated from the axoplasm of the squid giant axon

1985 • 289 citations

A transient array of parallel microtubules in frog eggs: Potential tracks for a cytoplasmic rotation that specifies the dorso-ventral axis

1988 • 249 citations

Changes in cell surface and cortical cytoplasmic organization during early embryogenesis in the preimplantation mouse embryo

1977 • 239 citations

Gene Activity in Early Development

1988 • 237 citations

The cytoskeletal framework and poliovirus metabolism

1979 • 231 citations

Axis determination in eggs of Xenopus laevis: A critical period before first cleavage, identified by the common effects of cold, pressure and ultraviolet irradiation

1983 • 226 citations

Formation of cytoskeletal elements during mouse embryogenesis

1984 • 218 citations

Localization of actin messenger RNA during early ascidian development

1983 • 204 citations

Behaviour of microtubules and actin filaments in livingDrosophilaembryos

1988 • 198 citations

The spatial distribution of polyribosomes in 3T3 cells and the associated assembly of proteins into the skeletal framework

1980 • 194 citations

Fodrin is the general spectrin-like protein found in most cells whereas spectrin and the TW protein have a restricted distribution

1983 • 191 citations

Intermediate filament protein synthesis in preimplantation murine embryos

1983 • 190 citations

Dynamic changes of the egg cortex

1981 • 189 citations

A yellow crescent cytoskeletal domain in ascidian eggs and its role in early development

1983 • 187 citations

Embryos, genes, and evolution: The developmental-genetic basis of evolutionary change

1983 • 185 citations

Translational initiation factor and ribosome association with the cytoskeletal framework fraction from HeLa cells

1984 • 180 citations

Analysis of the role of microfilaments and microtubules in acquisition of bipolarity and elongation of fibroblasts in hydrated collagen gels.

1984 • 177 citations

Nuclear elongation and cytokinesis in Drosophila montana

1971 • 176 citations

An introductory survey

1979 • 173 citations

Fluorescence visualization of the distribution of microfilaments in gonads and early embryos of the nematode Caenorhabditis elegans.

1986 • 167 citations

A time-lapse video image intensification analysis of cytoplasmic organelle movements during endosome translocation.

1984 • 158 citations

Aster formation in eggs of Xenopus laevis. Induction by isolated basal bodies.

1975 • 158 citations

The cytoskeleton : an introductory survey

1986 • 151 citations

Cytokeratin filament assembly in the preimplantation mouse embryo

1987 • 147 citations

Evidence for a functional role of the cytoskeleton in determination of the dorsoventral axis in Xenopus laevis eggs.

1983 • 141 citations

Electrical currents through full-grown and maturing Xenopus oocytes.

1979 • 138 citations

On the association of mRNA with the cytoskeleton in uninfected and adenovirus-infected human KB cells

1981 • 134 citations

Distribution and mode of arrangement of microfilamentous structures and actin in the cortex of the amphibian oocyte.

1976 • 134 citations

Actin in triton-treated cortical preparations of unfertilized and fertilized sea urchin eggs.

1979 • 131 citations

An analysis of the role of microfilaments in the establishment and maintenance of asymmetry in Caenorhabditis elegans zygotes

1988 • 131 citations

Intermediate-size filaments in a germ cell: Expression of cytokeratins in oocytes and eggs of the frog Xenopus.

1983 • 129 citations

Movement of myosin-coated beads on oriented filaments reconstituted from purified actin

1985 • 127 citations

Determinants of Spatial Organization

1979 • 126 citations

Distribution of F-actin during cleavage of the Drosophila syncytial blastoderm.

1984 • 120 citations

Polar asymmetry in the organization of the cortical cytokeratin system of Xenopus laevis oocytes and embryos

1987 • 119 citations

Aldolase exists in both the fluid and solid phases of cytoplasm [published erratum appears in J Cell Biol 1988 Dec;107(6 Pt 1):following 2463]

1988 • 118 citations

Redistribution of microtubules and pericentriolar material during the development of polarity in mouse blastomeres.

1987 • 112 citations

Antibodies as probes of cellular differentiation and cytoskeletal organization in the mouse blastocyst

1980 • 110 citations

Changes in the distribution of membranous organelles during mouse early development

1985 • 110 citations

Activators of protein kinase C trigger cortical granule exocytosis, cortical contraction, and cleavage furrow formation in Xenopus laevis oocytes and eggs.

1989 • 109 citations

Effect of viral infection on host protein synthesis and mRNA association with the cytoplasmic cytoskeletal structure.

1985 • 107 citations

Cytochalasin separates microtubule disassembly from loss of asymmetric morphology.

1981 • 105 citations

The development of centrifuged eggs of ascidians

1931 • 105 citations

The cytoskeleton. An introductory survey

1986 • 104 citations

Spatial distribution of messenger RNA in the cytoskeletal framework of ascidian eggs

1984 • 103 citations

Expression of cytokeratin polypeptides in mouse oocytes and preimplantation embryos

1983 • 102 citations

Calcium and neurulation in mammalian embryos

1985 • 101 citations

Association of methionyl-tRNA synthetase with detergent-insoluble components of the rough endoplasmic reticulum.

1983 • 98 citations

Bidirectional organelle transport can occur in cell processes that contain single microtubules.

1985 • 95 citations

Localization of cytoskeletal proteins in preimplantation mouse embryos

1980 • 95 citations

Microtubule arrays present during the syncytial and cellular blastoderm stages of the early Drosophila embryo

1986 • 93 citations

Germinal vesicle breakdown in the Xenopus laevis oocyte : description of a transient microtubular structure

1981 • 90 citations

Association of the epidermal growth factor receptor kinase with the detergent-insoluble cytoskeleton of A431 cells.

1985 • 89 citations

The cytoskeletal framework of sea urchin eggs and embryos: Developmental changes in the association of messenger RNA

1983 • 86 citations

Anti-tubulin immunofluorescence microscopy of microtubules present during the pronuclear movements of sea urchin fertilization

1981 • 86 citations

An investigation of microtubule organization and functions in living Drosophila embryos by injection of a fluorescently labeled antibody against tyrosinated alpha-tubulin.

1987 • 84 citations

Activation of rabbit muscle phosphofructokinase by F-actin and reconstituted thin filaments

1980 • 84 citations

The temporal and spatial relationships between cortical contraction, sperm trail formation, and pronuclear migration in fertilizedXenopus eggs

1982 • 82 citations

Transient localizations of messenger RNA in Xenopus laevis oocytes

1982 • 81 citations

Microtubules in ascidian eggs during meiosis, fertilization, and mitosis

1988 • 81 citations

Localization of fodrin during fertilization and early development of sea urchins and mice

1986 • 81 citations

Cytoplasmic phases in the first cell cycle of the activated frog egg

1983 • 80 citations

Reactivation of organelle movements along the cytoskeletal framework of a giant freshwater ameba.

1986 • 77 citations

Intermediate filaments in the Xenopus oocyte: the appearance and distribution of cytokeratin-containing filaments

1984 • 76 citations

Kinesin: possible biological roles for a new microtubule motor

1986 • 75 citations

Segregation of two spectrin forms in the chicken optic system: A mechanism for establishing restricted membrane-cytoskeletal domains in neurons

1984 • 74 citations

Protein kinase C acts downstream of calcium at entry into the first mitotic interphase of Xenopus laevis.

1990 • 70 citations

Changes in levels of polymeric tubulin associated with activation and dorsoventral polarization of the frog egg

1985 • 68 citations

Cytoskeletal reorganization during early mammalian development: Analysis using embedment-free sections

1986 • 68 citations

The cytoskeleton, endocytosis and cell polarity in the mouse preimplantation embryo

1986 • 68 citations

Levels of microtubules during the meiotic maturation of the Xenopus oocyte

1987 • 66 citations

Summary: Organization of the Cytoplasm

1982 • 65 citations

Differential accumulation and localization of maternal poly(A)-containing RNA during early development of the ascidian, Styela

1978 • 65 citations

Cell-cell contact modulation of myosin organization in the early mouse embryo

1983 • 64 citations

Oocytes and early embryos of Xenopus laevis contain intermediate filaments which react with anti-mammalian vimentin antibodies

1984 • 63 citations

Transformation of the amphibian oocyte into the egg: Structural and biochemical events

1990 • 63 citations

Changes in the distribution of a spectrin-like protein during development of the preimplantation mouse embryo.

1985 • 63 citations

Assembly-disassembly of actin bundles in starfish oocytes: An analysis of actin-associated proteins in the isolated cortex

1984 • 62 citations

Wave of cortical actin polymerization in the sea urchin egg

1987 • 61 citations

Formation of the amphibian grey crescent: Effects of colchicine and cytochalasin B

1978 • 60 citations

Cyclic assembly-disassembly of cortical microtubules during maturation and early development of starfish oocytes

1984 • 60 citations

Filamentous actin organization in the unfertilized sea urchin egg cortex

1988 • 57 citations

Distribution of microtubules during the breakdown of the nuclear envelope of the Xenopus oocyte: an immunocytochemical study

1986 • 57 citations

Unfertilized sea urchin eggs contain a discrete cortical shell of actin that is subdivided into two organizational states

1988 • 55 citations

Cell surface and cytoskeletal elements: Cavitation in the mouse preimplantation embryo

1981 • 53 citations

The metabolism of SV40 RNA is associated with the cytoskeletal framework

1981 • 53 citations

Association of creatine phosphokinase with the cytoskeleton of cultured mammalian cells.

1980 • 52 citations

Ooplasmic segregation in theTubifex egg: Mode of pole plasm accumulation and possible involvement of microfilaments

1982 • 51 citations

Localization of myosin in the preimplantation mouse embryo

1983 • 50 citations

In vitro translocation of organelles along microtubules

1985 • 50 citations

Variations in the distribution and migration of centriole duplexes in mitotic ptk2 cells studied by immunofluorescence microscopy

1980 • 50 citations

Tubulin Assembly Sites and the Organization of Microtubule Arrays in Mammalian Cells

1982 • 49 citations

Effects of colcemid on cavitation during mouse blastocoele formation

1980 • 47 citations

Microfilaments during sea urchin fertilization: Fluorescence detection with rhodaminyl phalloidin

1986 • 46 citations

Spectrin in mouse gametogenesis and embryogenesis

1986 • 45 citations

Changes in the distribution of cortical myosin during the cellularization of the Drosophila embryo

1980 • 44 citations

Cytoskeleton in preimplantation mouse development

1988 • 44 citations

Bipolar segregation of mitochondria, actin network, and surface in the Tubifex egg: Role of cortical polarity

1986 • 44 citations

The spatial distribution of maternal mRNA is determined by a cortical cytoskeletal domain in Chaetopterus eggs

1985 • 44 citations

Dynamics of the actin microfilament system in the Tubifex egg during ooplasmic segregation

1984 • 41 citations

The cortical cytoskeleton and its role in sperm penetration of the mammalian egg

1990 • 41 citations

Fate of secretory proteins trapped in oocytes of Xenopus laevis by disruption of the cytoskeleton or by imbalanced subunit synthesis.

1981 • 39 citations

Annual review of cell biology

1986 • 38 citations

Accumulation of fluorescently labeled actin in the cortical layer in sea urchin eggs after fertilization

1988 • 37 citations

SV40 virions and viral RNA metabolism are associated with cellular substructures.

1982 • 37 citations

Vimentin expression in oocytes, eggs and early embryos of Xenopus laevis

1988 • 37 citations

Many cytoskeletal proteins associate with the HeLa cytoskeleton during translation in vitro

1983 • 36 citations

Intracellular signals trigger ultrastructural events characteristic of meiotic maturation in oocytes of Xenopus laevis

1989 • 36 citations

Specialized cytoskeletal elements in mammalian eggs: Structural and biochemical evidence for their composition

1989 • 35 citations

Ooplasmic segregation of the myoplasmic actin network in stratified ascidian eggs

1984 • 35 citations

Influence of cytochalasin B on oocyte maturation in Xenopus laevis

1986 • 35 citations

The Multiple Roles which Cell Division can Play in the Localization of Developmental Potential

1979 • 34 citations

Germinal vesicle migration and dissolution in Rana pipiens oocytes: effect of steroids and microtubule poisons

1987 • 32 citations

Cytoskeleton of the mouse egg and embryo: Reorganization of planar elements

1991 • 32 citations

Localization of actin networks during early development of Tubifex embryos

1988 • 31 citations

Myosin rings and spreading in mouse blastomeres.

1984 • 30 citations

THE EFFECTS OF VINBLASTINE ON ISOLATED XENOPUS OOCYTES

1972 • 29 citations

Soluble cytokeratins in Xenopus laevis oocytes and eggs

1987 • 29 citations

Identification of proteins and mRNAs in isolated yellow crescents of ascidian eggs

1985 • 27 citations

The ultrastructure of surface layers isolated from fertilized and chemically stimulated sea urchin eggs

1980 • 26 citations

Localization of messenger RNA in the cortex ofChaetopterus eggsand early embryos

1983 • 25 citations

Microtubules in immature oocytes of Xenopus laevis.

1985 • 25 citations

Early embryogenesis in Caenorhabditis elegans: The cytoskeleton and spatial organization of the zygote

1988 • 25 citations

Presence of microtubules in isolated cortices of prophase I and metaphase II oocytes in Xenopus laevis

1988 • 25 citations

Actin in Xenopus Development: Indirect Immunofluorescence Study of Actin Localization

1981 • 24 citations

Spatial reorganization of actin, tubulin and histone mRNAs during meiotic maturation and fertilization in Xenopus oocytes

1988 • 24 citations

What Does the Comparative Study of Development Tell Us About Evolution?

1982 • 22 citations

Microtubules during germinal vesicle breakdown (GVBD) of Xenopus oocytes : effect of Ca²⁺ ionophore A-23187 and taxol

1985 • 20 citations

Identification of microtubule‐associated proteins (MAPs) in Xenopus oocyte

1985 • 20 citations

In vitro inhibition of tubulin assembly by a ribonucleoprotein complex associated with the free ribosome fraction isolated from Xenopus laevis oocytes: effect at the level of microtubule-associated proteins

1984 • 19 citations

Role of calcium in the localization of maternal poly(A)+RNA and tubulin mRNA in Xenopus oocytes

1988 • 17 citations

Binding of hela spectrin to a specific hela membrane fraction

1983 • 16 citations

Interaction between rat brain microtubule associated proteins (MAPs) and free ribosomes from Xenopus oocyte: a possible mechanism for the in ovo distribution of MAPs

1984 • 16 citations

Developmental significance of a cortical cytoskeletal domain in Chaetopterus eggs

1985 • 13 citations

A Freeze‐Sectioning Method for Preparation of the Detergent‐Resistant Cytoskeleton Identifies Stage‐Specific Cytoskeleal Proteins and Associated mRNA in Xenopus Oocytes and Embryos

1989 • 12 citations

Synthesis, assembly and organization of the cytoskeleton during early amphibian development.

1990 • 12 citations

A method for analysis of the detergent-resistant cytoskeleton of cells within organs

1987 • 11 citations

Tyrosyl kinases acquired from anchorage-independent cells by a membrane-enveloped virus.

1984 • 7 citations

Quick‐freeze, deep‐etch, rotary‐shadow views of the extracellular matrix and cortical cytoskeleton of Xenopus laevis eggs

1989 • 7 citations

Influence of osmolytes, thin filaments, and solubility state on elasmobranch phosphofructokinase in vitro

1984 • 6 citations

Announcements

1982 • 3 citations

Deleted Work

1955 • 0 citations