Death of Two Subjects Due to Imipramine and Desipramine Metabolite Accumulation During Chronic Therapy: A Review of the Literature and Possible Mechanisms

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1982 • 1,876 citations

Comprehensive Textbook of Psychiatry

1994 • 1,370 citations

Disposition of Toxic Drugs and Chemicals in Man

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Clinical significance of the sparteine/debrisoquine oxidation polymorphism

1989 • 292 citations

The Forensic Science Implications of Site and Temporal Influences on Postmortem Blood-Drug Concentrations

1990 • 269 citations

Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds

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Recent Developments in Hepatic Drug Oxidation

1990 • 189 citations

Sudden Death in Children Receiving Norpramin®: A Review of Three Reported Cases and Commentary

1991 • 182 citations

Another Sudden Death in a Child Treated with Desipramine

1993 • 177 citations

Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver.

1993 • 168 citations

Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype

1991 • 162 citations

The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine

1991 • 139 citations

Site Dependence of Drug Concentrations in Postmortem Blood—A Case Study*

1987 • 139 citations

Fluoxetine Drug-Drug Interactions

1990 • 128 citations

Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine

1991 • 114 citations

Treatment of childhood hyperactivity with desipramine: Plasma drug concentration, cardiovascular effects, plasma and urinary catecholamine levels, and clinical response

1986 • 101 citations

Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism

1986 • 98 citations

Inhibition of desmethylimipramine 2-hydroxylation by drugs in human liver microsomes

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Steady-state levels of imipramine and its metabolites: Significance of dose-dependent kinetics

1986 • 77 citations

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Desipramine in the Treatment of Children with Attention Deficit Disorder

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Tricyclic antidepressants: plasma levels and clinical findings in overdose

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Liver and Blood Postmortem Tricyclic Antidepressant Concentrations

1988 • 50 citations

The role of S‐mephenytoin 4'‐hydroxylase in imipramine metabolism by human liver microsomes: a two‐enzyme kinetic analysis of N‐ demethylation and 2‐hydroxylation.

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Sudden Death Putatively Related to Desipramine Treatment in Youth: A Fifth Case and a Review of Speculative Mechanisms

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Fluoxetine: Adverse Effects and Drug-Drug Interactions

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Postmortem Tricyclic Antidepressant Concentrations: Assessing Cause of Death Using Parent Drug to Metabolite Ratio

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Plasma Levels of Imipramine and Metabolites in 68 Hospitalized Children

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Genetically Determined Adverse Drug Reactions Involving Metabolism

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Evaluation of Sudden Death in Psychiatric Patients with Special Reference to Phenothiazine Therapy: Forensic Pathology

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Determination of Thioridazine Enantiomers in Human Serum by Sequential Achiral and Chiral High-Performance Liquid Chromatography

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Analysis of imipramine and three metabolites produced by isozyme CYP2D6 expressed in a human cell line

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Postmortem Tricyclic Antidepressant Concentrations

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The Pharmacotherapy of Depressive Illness in Adolescence: III. Diagnostic and Conceptual Issues in Studies of Tricyclic Antidepressants

1992 • 14 citations

Postmortem Pharmacokinetics of Tricyclic Antidepressants: Are Some Deaths During Treatment Misattributed to Overdose?

1993 • 7 citations