From toxicological problem to therapeutic use: The discovery of the mode of action of 2‐(2‐nitro‐4‐trifluoromethylbenzoyl)‐1,3‐cyclohexanedione (NTBC), its toxicology and development as a drug

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

Effects of ingestion of disproportionate amounts of amino acids.

1970 • 1,123 citations

Treatment of hereditary tyrosinaemia type I by inhibition of 4-hydroxyphenylpyruvate dioxygenase

1992 • 625 citations

On the enzymic defects in hereditary tyrosinemia.

1977 • 453 citations

The discovery and structural requirements of inhibitors of p-hydroxyphenylpyruvate dioxygenase

1997 • 211 citations

SC‐0051, a 2‐benzoyl‐cyclohexane‐1,3‐dione bleaching herbicide, is a potent inhibitor of the enzyme p‐hydroxyphenylpyruvate dioxygenase

1993 • 190 citations

Inhibition of 4-Hydroxyphenylpyruvate Dioxygenase by 2-(2-Nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione and 2-(2-Chloro-4-methanesulfonylbenzoyl)-cyclohexane-1,3-dione

1995 • 111 citations

Inhibition of Barnyardgrass 4-Hydroxyphenylpyruvate Dioxygenase by Sulcotrione

1994 • 93 citations

Purification and some properties of human 4-hydroxyphenylpyruvate dioxygenase (I).

1977 • 81 citations

The occurrence of β-triketones in the steam-volatile oils of some myrtaceous Australian plants

1968 • 63 citations

Four-Hydroxyphenylpyruvic Acid Oxidase Deficiency with Normal Fumarylacetoacetase: a New Variant Form of Hereditary Hypertyrosinemia

1983 • 59 citations

Purification and some properties of 4-hydroxyphenylpyruvate dioxygenase from Pseudomonas sp. P.J. 874

1977 • 49 citations

Tissue Distribution of 2-(2-Nitro-4-trifluoromethylbenzoyl)cyclohexane-1,3-dione (NTBC): Effect on Enzymes Involved in Tyrosine Catabolism and Relevance to Ocular Toxicity in the Rat

1996 • 48 citations

Chronic Tyrosinemia Associated with 4-Hydroxyphenylpyruvate Dioxygenase Deficiency with Acute Intermittent Ataxia and without Visceral and Bone Involvement

1983 • 45 citations

Evaluation of the mechanism of action of the bleaching herbicide SC-0051 by HPLC analysis

1989 • 38 citations

Characterization of the Interaction of 2-[2-Nitro-4-(trifluoromethyl)benzoyl]-4,4,6,6-tetramethylcyclohexane-1,3,5-trione with Rat Hepatic 4-Hydroxyphenylpyruvate Dioxygenase

1996 • 33 citations

[19] 4-Hydroxyphenylpyruvate dioxygenase from human liver

1987 • 30 citations

Inhibition of pigment synthesis by 1,3-dimethyl-4-(2,4-dichlorobenzoyl)-5-hydroxypyrazole, norflurazon, and new herbicidal compounds in radish and flatsedge plants

1987 • 27 citations

Excess dietary tyrosine and corneal lesions

1973 • 23 citations

Tyrosinemia II: Lessons in Molecular Pathophysiology

1983 • 23 citations

Weed Control in No-tillage and Conventional Corn (Zea mays) with ICIA-0051 and SC-0774

1990 • 15 citations

Response of the lysosomal system of the corneal epithelium to tyrosine-induced cell injury.

1977 • 11 citations

The effect of diet on the ophthalmological, clinical and biochemical aspects of Richner-Hanhart syndrome: A morphological ultrastructural study of the cornea and the conjunctiva

1987 • 10 citations

The Corneal Effects of 2-(2-Nitro-4-Trifluoromethyl-Benzoyl)-Cyclohexane 1,3-Dione (NTBC) in the Rat

1995 • 9 citations

Benzoylcyclohexanedione herbicides are strong inhibitors of purified p‐hydroxyphenylpyruvic acid dioxygenase of maize

1995 • 8 citations

Inhibition of phenylalanine hydroxylase, a pterin-requiring monooxygenase, by oudenone and its derivatives.

1982 • 7 citations

Keratopathy in tyrosinemia.

1976 • 6 citations

Keratopathy in tyrosinemia.

1976 • 5 citations