Calcium Regulation of Smooth Muscle Contraction

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Calmodulin Plays a Pivotal Role in Cellular Regulation

1980 • 2,441 citations

Changes in the Cross-Striations of Muscle during Contraction and Stretch and their Structural Interpretation

1954 • 1,655 citations

Structural Changes in Muscle During Contraction: Interference Microscopy of Living Muscle Fibres

1954 • 1,532 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain.

1977 • 865 citations

Cyclic 3′,5′-nucleotide phosphodiesterase

1970 • 824 citations

Calmodulin

1982 • 771 citations

Myosin Phosphorylation and the Cross-Bridge Cycle in Arterial Smooth Muscle

1981 • 705 citations

Identification of the Ca²⁺‐dependent modulator protein as the fourth subunit of rabbit skeletal muscle phosphorylase kinase

1978 • 619 citations

Reconstitution of Troponin Activity from Three Protein Components

1971 • 594 citations

Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.

1980 • 568 citations

Identification of a calcium-binding protein as a calcium-dependent regulator of brain adenylate cyclase.

1975 • 546 citations

Binding of trifluoperazine to the calcium-dependent activator of cyclic nucleotide phosphodiesterase.

1977 • 544 citations

Calcium-induced exposure of a hydrophobic surface on calmodulin

1980 • 520 citations

Purification and characterization of smooth muscle myosin light chain kinase.

1981 • 501 citations

Control of microtubule assembly-disassembly by calcium-dependent regulator protein.

1978 • 493 citations

Phosphodiesterase protein activator mimics red blood cell cytoplasmic activator of (Ca2+-Mg2+)ATPase

1977 • 483 citations

Discovery of A Ca²⁺‐and calmodulin‐dependent protein phosphatase

1982 • 476 citations

Concerted regulation of cardiac sarcoplasmic reticulum calcium transport by cyclic adenosine monophosphate dependent and calcium-calmodulin-dependent phosphorylations

1979 • 454 citations

Purification of a calmodulin-binding protein from chicken gizzard that interacts with F-actin.

1981 • 425 citations

Partial purification of the Ca2+-Mg2+ ATPase activator from human erythrocytes: Its similarity to the activator of 3′:5′ — cyclic nucleotide phosphodiesterase

1977 • 395 citations

Light-chain phosphorylation controls the conformation of vertebrate non-muscle and smooth muscle myosin molecules

1983 • 393 citations

The relationship between calmodulin binding and phosphorylation of smooth muscle myosin kinase by the catalytic subunit of 3‘:5‘ cAMP-dependent protein kinase.

1981 • 388 citations

Phosphorylation of smooth muscle myosin light chain kinase by the catalytic subunit of adenosine 3‘: 5‘-monophosphate-dependent protein kinase.

1978 • 386 citations

Selective binding of antipsychotics and other psychoactive agents to the calcium-dependent activator of cyclic nucleotide phosphodiesterase.

1979 • 378 citations

Hydrophobic regions function in calmodulin-enzyme(s) interactions.

1980 • 363 citations

Protein activator of cyclic 3′:5′-nucleotide phosphodiesterase of bovine or rat brain also activates its adenylate cyclase

1975 • 361 citations

Calcium-regulated modulator protein interacting agents inhibit smooth muscle calcium-stimulated protein kinase and ATPase.

1980 • 335 citations

Purification and Properties of the Components from Troponin

1973 • 329 citations

Force measurements in skinned muscle fibres

1969 • 328 citations

Activation of skeletal muscle myosin light chain kinase by calcium(2+) and calmodulin

1980 • 326 citations

Glycerinated Skeletal and Smooth Muscle: Calcium and Magnesium Dependence

1965 • 305 citations

Effect of phosphorylation of smooth muscle myosin on actin activation and Ca2+ regulation.

1977 • 302 citations

A phosphorylated light-chain component of myosin from skeletal muscle

1973 • 301 citations

The light chains of scallop myosin as regulatory subunits

1973 • 294 citations

A bent monomeric conformation of myosin from smooth muscle.

1982 • 283 citations

Phorbol ester-induced activation of human platelets is associated with protein kinase C phosphorylation of myosin light chains

1983 • 265 citations

Structure and Function of Chicken Gizzard Myosin1

1978 • 265 citations

Electron probe analysis of vascular smooth muscle. Composition of mitochondria, nuclei, and cytoplasm.

1979 • 263 citations

Vascular smooth muscle: The first recorded Ca2+ transients

1982 • 260 citations

Reversible phosphorylation of smooth muscle myosin, heavy meromyosin, and platelet myosin.

1981 • 259 citations

Calcium-dependent regulator of NAD kinase in higher plants

1978 • 254 citations

Modulator binding protein. Bovine brain protein exhibiting the Ca2+-dependent association with the protein modulator of cyclic nucleotide phosphodiesterase.

1977 • 252 citations

Myosin light-chain phosphatase

1976 • 246 citations

Roles of calcium and phosphorylation in the regulation of the activity of gizzard myosin

1978 • 244 citations

Regulation of Smooth Muscle Actomyosin

1981 • 234 citations

[30] Smooth muscle myosin light chain kinase

1983 • 229 citations

Electron Microscopic Studies of Myosin Molecules from Chicken Gizzard Muscle I: The Formation of the Intramolecular Loop in the Myosin Tail1

1982 • 204 citations

Selective inhibitors of Ca2+-binding modulator of phosphodiesterase produce vascular relaxation and inhibit actin-myosin interaction.

1979 • 201 citations

Widespread Occurence of Calcium-Activated, Phospholipid Dependent Protein Kinase in Mammalian Tissues1

1981 • 196 citations

Purification and properties of myosin light-chain kinase from fast skeletal muscle

1977 • 195 citations

Composition of the myosin light chain kinase from chicken gizzard

1977 • 192 citations

Adenosine 5′-0(3-thiotriphosphate) in the control of phosphorytase activity

1974 • 190 citations

Irreversible thiophosphorylation and activation of tension in functionally skinned rabbit ileum strips by [35S]ATP gamma S.

1979 • 181 citations

Troponin C-like proteins (calmodulins) from mammalian smooth muscle and other tissues

1979 • 177 citations

Properties of a Heat-stable Phosphodiesterase Activating Factor isolated from Brain Extract

1970 • 171 citations

A novel vascular relaxing agent, N-(6--aminohexyl)-5-chloro-1-naphthalensulfonamide which affects vascular smooth muscle actomyosin.

1978 • 171 citations

The Croonian Lecture, 1979: Regulation of muscle contraction

1980 • 170 citations

Role of Ca2+ and myosin light chain phosphorylation in regulation of smooth muscle

1982 • 169 citations

Ca2+, cAMP, and changes in myosin phosphorylation during contraction of smooth muscle

1983 • 166 citations

Regulatory light-chains and scallop myosin: Full dissociation, reversibility and co-operative effects

1980 • 166 citations

<b>CONTROL OF ACTIN-MYOSIN INTERACTION OF GIZZARD SMOOTH MUSCLE BY CALMODULIN- AND CALDESMONLINKED FLIP-FLOP </b><b>MECHANISM </b>

1982 • 162 citations

Chicken Gizzard: Relation Between Calcium-Activated Phosphorylation and Contraction

1979 • 160 citations

Calcium-dependent protein binding to phenothiazine columns.

1982 • 159 citations

Myosin filaments have non-phosphorylated light chains in relaxed smooth muscle

1981 • 155 citations

Homology of myosin DTNB light chain with alkali light chains, troponin C and parvalbumin

1976 • 155 citations

The Contractile Apparatus of Smooth Muscle

1980 • 154 citations

Calcium-Dependent Stress Maintenance Without Myosin Phosphorylation in Skinned Smooth Muscle

1983 • 145 citations

Regulation of myosin light chain and phosphorylase phosphorylation in tracheal smooth muscle.

1982 • 140 citations

Dephosphorylation of the 20,000-dalton light chain of myosin by two different phosphatases from smooth muscle.

1980 • 139 citations

Production and characterization of an antibody to myosin light chain kinase and intracellular localization of the enzyme

1981 • 137 citations

Phosphorylation of Smooth Muscle Myosin: Evidence for Cooperativity Between the Myosin Heads

1981 • 136 citations

Calmodulin is essential for smooth muscle contraction

1981 • 134 citations

Myosin-linked regulatory systems

1981 • 132 citations

Isolation of the native form of chicken gizzard myosin light-chain kinase

1984 • 125 citations

Correlation of enzymatic properties and conformation of smooth muscle myosin

1983 • 124 citations

Calcium-dependent interaction of S100b, troponin C, and calmodulin with an immobilized phenothiazine.

1981 • 123 citations

Inhibition of smooth muscle tension by cyclic AMP-dependent protein kinase

1981 • 123 citations

The role of myosin light chain kinase phosphorylation in beta-adrenergic relaxation of tracheal smooth muscle.

1983 • 121 citations

Purification and characterization of a multisubunit phosphatase from turkey gizzard smooth muscle. The effect of calmodulin binding to myosin light chain kinase on dephosphorylation.

1983 • 120 citations

Effects of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide and other calmodulin antagonists (calmodulin interacting agents) on calcium-induced contraction of rabbit aortic strips.

1981 • 116 citations

Reversible phosphorylation and dephosphorylation of the 20,000-dalton light chain of myosin during the contraction-relaxation-contraction cycle of arterial smooth muscle.

1980 • 110 citations

Calcium binding regions of myosin ‘Regulatory’ light chains

1976 • 109 citations

Adenosine 3‘:5‘-monophosphate-mediated inhibition of myosin light chain phosphorylation in bovine aortic actomyosin.

1979 • 108 citations

Myosin phosphorylation during contraction and relaxation of tracheal smooth muscle.

1980 • 103 citations

Calcium ion-regulated thin filaments from vascular smooth muscle

1980 • 103 citations

Calcium-independent myosin light chain kinase of smooth muscle. Preparation by limited chymotryptic digestion of the calcium ion dependent enzyme, purification and characterization

1982 • 101 citations

Phosphorylation of the 20,000-dalton light chain of myosin of intact arterial smooth muscle in rest and in contraction.

1979 • 100 citations

Cyclic nucleotides and smooth muscle.

1974 • 99 citations

Calmodulin-binding proteins from brain and other tissues

1979 • 98 citations

Regulation of Muscle Contraction

1983 • 98 citations

ULTRASTRUCTURAL STUDIES ON THE CONTRACTILE MECHANISM OF SMOOTH MUSCLE

1969 • 93 citations

Circular dichroism studies on Ca2+-dependent protein modulator oxidized with N-chlorosuccinimide.

1978 • 91 citations

Phosphorylation-dependent activated tension in skinned gizzard muscle fibers in the absence of Ca2+.

1982 • 91 citations

Chemical modification studies on the Ca2+-dependent protein modulator: the role of methionine residues in the activation of cyclic nucleotide phosphodiesterase.

1978 • 90 citations

Characterization of antibodies to smooth muscle myosin kinase and their use in localizing myosin kinase in nonmuscle cells.

1981 • 89 citations

Ca2+-phospholipid dependent phosphorylation of smooth muscle myosin

1982 • 85 citations

Role of basic residues in the phosphorylation of synthetic peptides by myosin light chain kinase.

1983 • 83 citations

Myosin phosphorylation and regulation of cross-bridge cycle in tracheal smooth muscle

1983 • 82 citations

Effects of various calmodulin antagonists on contraction of rabbit aortic strips.

1982 • 82 citations

Ordered phosphorylation of the two 20,000 molecular weight light chains of smooth muscle myosin

1983 • 81 citations

Effect of novel specific myosin light chain kinase inhibitors on Ca2+-activated Mg2+-ATPase of chicken gizzard actomyosin

1979 • 79 citations

Fragmentation of gizzard myosin by alpha-chymotrypsin and papain, the effects on ATPase activity, and the interaction with actin.

1980 • 78 citations

Characterization of a Mg2+-dependent phosphatase from turkey gizzard smooth muscle.

1983 • 77 citations

Chemical modification studies on the Ca²⁺ ion-dependent protein modulator: the role of methionine residues in the activation of cyclic nucleotide phosphodiesterase. Appendix: Circular dichroism studies on Ca²⁺ ion-dependent protein modulator oxidized with N-chlorosuccinimide

1978 • 76 citations

Phosphorylation of a light chain component of myosin from smooth muscle

1976 • 76 citations

Involvement of an Acidic Protein in Regulation of Smooth Muscle Contraction by the Tropomyosin-Leiotonin System1

1978 • 76 citations

Adenosine Triphosphate-Induced Reversible Change in the Conformation of Chicken Gizzard Myosin and Heavy Meromyosin1

1982 • 76 citations

Studies on the effect of phosphorylation of the 20,000 Mr light chain of vertebrate smooth muscle myosin

1983 • 75 citations

Bovine stomach myosin light chain kinase: purification, characterization, and comparison with the turkey gizzard enzyme

1982 • 73 citations

Calcium-activated tension: the role of myosin light chain phosphorylation.

1980 • 68 citations

The L‐2 light chain of chicken skeletal muscle myosin

1977 • 67 citations

Calcium and monovalent ions in smooth muscle.

1982 • 67 citations

<b>CALCIUM REGULATORY MECHANISM IN VERTEBRATE SMOOTH </b><b>MUSCLE </b>

1980 • 63 citations

Troponin and Its Components from Ascidian Smooth Muscle1

1981 • 63 citations

Purification of a myosin phosphatase from bovine aortic smooth muscle.

1982 • 62 citations

The binding of smooth muscle myosin light chain kinase to actin

1982 • 62 citations

Caldesmon, a calmodulin‐binding, F actin‐interacting protein, is present in aorta, uterus and platelets

1983 • 57 citations

Does Phosphoryiation of Myosin Light Chain Have Direct Relation to Regulation in Smooth Muscle?1

1977 • 56 citations

Effect of calmodulin, Ca2+, and cAMP protein kinase on skinned tracheal smooth muscle

1984 • 54 citations

Epidermal growth factor stimulates tyrosine phosphorylation of the myosin regulatory light chain from smooth muscle.

1983 • 53 citations

Filament Organization and Contractile Function in Vertebrate Smooth Muscle

1979 • 52 citations

Cyclic-AMP mediated relaxation of chemically skinned fibres of smooth muscle

1981 • 52 citations

Affinity-chromatographic isolation and some properties of troponin C from different muscle types

1977 • 51 citations

Phosphorylation of smooth muscle myosin light chains by cAMP-dependent protein kinase.

1980 • 51 citations

The structural requirements of substrates of cyclic AMP‐dependent protein kinase

1982 • 50 citations

Disruption of the sarcolemma of mammalian skeletal muscle fibers by homogenization

1975 • 49 citations

Inhibition of Ca2+-activated tension and myosin light chain phosphorylation in skinned smooth muscle strips by the phenothiazines

1980 • 48 citations

Calmodulin stimulation and calcium regulation of smooth muscle adenylate cyclase activity.

1983 • 48 citations

Preparation and characterization of frog muscle myosin subfragment 1 and actin

1978 • 47 citations

Calcium regulation of porcine aortic myosin.

1981 • 46 citations

Nonlinear Dependence of Actin-Activated Mg2+-ATPase Activity on the Extent of Phosphorylation of Gizzard Myosin and H-Meromyosin1

1982 • 44 citations

Effect of phosphorylation on the actin-activated atpase activity of myosin

1981 • 42 citations

Cyclic AMP‐dependent inhibition of smooth muscle actomyosin

1979 • 41 citations

Gizzard Troponin1

1975 • 40 citations

Ca2+ Regulation in Vascular Smooth Muscle1

1977 • 40 citations

Trifluoperazine can distinguish between myosin light chain kinase-linked and troponin C-linked control of actomyosin interaction by Ca++

1980 • 40 citations

Cyclic adenosine 3′,5′-monophosphate-dependent regulation of purified bovine aortic calcium/calmodulin-dependent myosin light chain kinase

1981 • 39 citations

Phosphorylation of smooth muscle myosin and myosin light chains.

1980 • 38 citations

Uterine smooth muscle: Troponin

1971 • 38 citations

Ca2+, calmodulin and cycic AMP-dependent modulation of actin-myosin interactions in aorta

1981 • 36 citations

Purification of Gizzard Myosin Light-Chain Phosphatase, and Reversible Changes in the ATPase and Superprecipitation Activities of Actomyosin in the Presence of Purified Preparations of Myosin Light-Chain Phosphatase and Kinase1

1982 • 35 citations

Superprecipitation of gizzard actomyosin, and tension in gizzard muscle skinned fibers in the presence of nucleotides other than ATP

1982 • 35 citations

Phosphorylation of the calcium ion-regulated thin filaments from vascular smooth muscle A new regulatory mechanism?

1981 • 34 citations

Regulation of contraction and thick filament assembly-disassembly in glycerinated vertebrate smooth muscle cells.

1983 • 34 citations

Actomyosin of Smooth Muscle

1982 • 33 citations

Effects of the calmodulin antagonist, fluphenazine, on phosphorylation of myosin and phosphorylase in intact smooth muscle.

1983 • 32 citations

REVERSIBLE DISAGGREGATION OF MYOFILAMENTS IN VERTEBRATE SMOOTH MUSCLE

1973 • 32 citations

Phosphorylation of smooth muscle myosin light chain by five different kinases

1983 • 31 citations

Gizzard Ca2+-independent myosin light chain kinase: evidence in favor of the phosphorylation theory.

1983 • 31 citations

Occurrence and Function of Cyclic Nucleotides in Blood Vessels

1976 • 30 citations

Thiophosphate-activated phosphorylase kinase as a probe in the regulation of phosphorylase phosphatase

1976 • 30 citations

Purification and characterization of myosin light-chain kinase from porcine myometrium and its phosphorylation and modulation by cyclic amp-dependent protein kinase

1983 • 30 citations

Arterial Tropomyosin and a Relaxing Protein Fraction from Vascular Smooth Muscle

1972 • 29 citations

Protein phosphorylation during spontaneous contraction of smooth muscle

1980 • 29 citations

Is smooth muscle myosin a substrate for the cAMP‐dependent protein kinase?

1981 • 29 citations

Activation by actin of ATPase activity of chemically modified gizzard myosin without phosphorylation

1979 • 28 citations

Soluble relaxation factor from vascular smooth muscle: A myosin light chain phosphatase?

1982 • 28 citations

Phosphorylation of a synthetic heptadecapeptide by smooth muscle myosin light chain kinase.

1982 • 27 citations

Subcellular localization of myosin light chain kinase in skeletal, cardiac, and smooth muscles.

1982 • 25 citations

Non-correlation of phosphorylation of the P-light chain and the actin activation of the ATPase of chicken gizzard myosin

1982 • 24 citations

Isolation of two myosin light-chain kinases from bovine carotid artery and their regulation by phosphorylation mediated by cyclic AMP-dependent protein kinase

1982 • 23 citations

Chemical Energetics of contraction in mammalian smooth muscle.

1982 • 22 citations

Properties of the calcium-sensitive components of bovine arterial actomyosin

1977 • 22 citations

Regulation of Myosin-filament Assembly by Light-chain Phosphorylation

1982 • 21 citations

An aortic spontaneously active phosphatase dephosphorylates myosin and inhibits actin-myosin interaction

1983 • 21 citations

Reversible Changes in the State of Phosphorylation of Gizzard Myosin, in That of Gizzard Myosin Assembly, in the ATPase Activity of Gizzard Myosin, in That of Actomyosin and in the Superprecipitation Activity1

1982 • 17 citations

Phosphorylation of chicken gizzard myosin and the Ca²⁺‐sensitivity of the actin‐activated Mg²⁺‐ATPase

1983 • 14 citations

The influence of temperature on the thick filaments of vertebrate smooth muscle

1973 • 14 citations

Properties and function of phosphatases from vascular smooth muscle.

1983 • 13 citations

Purification of Chicken Gizzard Myosin Light-Chain Kinase, and Its Calcium and Strontium Sensitivities as Compared with Those of Superprecipitation and ATPase Activities of Actomyosin1

1982 • 13 citations

Regulatory Protein of Bovine Tracheal Smooth Muscle

1976 • 13 citations

Identification of the native form of chicken gizzard myosin light chain kinase with the aid of monoclonal antibodies

1983 • 12 citations

N-Terminal Region of Gizzard Myosin Heavy Chain Is Critical for the ATPase Activity1

1981 • 11 citations

Thiolysis of dinitrophenylated sulfhydryl groups in gizzard myosin. Restoration of regulatory properties in a reconstituted actomyosin.

1982 • 11 citations

Identification of Myosin A, Actin and Native Tropomyosin Constituting of Arterial Contractile Protein (Myosin B) and Their Characteristics

1973 • 10 citations

Regulatory Protein of Vascular Smooth Muscle

1976 • 10 citations

Dinitrophenylation of chicken gizzard myosin. Reactivity of the 17 000-dalton light chain

1981 • 10 citations

Cyclic AMP-stimulated phosphorylation of bovine tracheal smooth muscle contractile and non-contractile proteins

1976 • 10 citations

A reversible change in the functional organization of thin filaments in smooth muscle fibers.

1982 • 9 citations

Disappearance of Smooth Muscle Thick Filaments during K<SUP>+</SUP> Contraction

1979 • 9 citations

Cooperative behavior of smooth muscle myosin.

1982 • 8 citations

Effects of phenothiazines on calcium induced contractions of chemically skinned smooth muscle.

1980 • 8 citations

Ca2+ Regulation Not Associated with Phosphorylation of Myosin Light Chain in Aortic Intima Smooth Muscle

1983 • 7 citations