Pharmacodynamic and Safety Results of PEG-Hirudin in Healthy Volunteers
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Abstract
References (19)
Platelet aggregation in partially obstructed vessels and its elimination with aspirin.
1976 • 765 citations
The Standardized Normal Ivy Bleeding Time and Its Prolongation by Aspirin
1969 • 672 citations
THE RELATION OF BLOOD PLATELETS TO HEMORRHAGIC DISEASE
1910 • 473 citations
The development of hirudin as an antithrombotic drug
1994 • 246 citations
Prevention of deep-vein thrombosis after total hip replacement: direct thrombin inhibition with recombinant hirudin, CGP 39393
1996 • 182 citations
Pharmacological Studies on the Antithrombotic Action of Hirudin in Experimental Animals
1982 • 121 citations
A polyexponential deconvolution method. Evaluation of the “gastrointestinal bioavailability” and meanin vivo dissolution time of some ibuprofen dosage forms
1985 • 72 citations
Standardization of symbols in clinical pharmacology
1988 • 60 citations
Effects of chemotherapeutic and immunosuppressive drugs on the production of erythropoietin in human hepatoma cultures
1993 • 40 citations
Effects of Hirudin on Activated Partial Thromboplastin Time Determined with Ten Different Reagents
1993 • 39 citations
Development of a chromogenic substrate assay for the determination of hirudin in plasma
1991 • 32 citations
On the isolation of the thrombin inhibitor hirudin
1985 • 31 citations
The effect of a long-acting recombinant hirudin (PEG-hirudin) on experimental disseminated intravascular coagulation (DIC) in rabbits
1993 • 28 citations
The effect of hirudin on endotoxin induced disseminated intravascular coagulation (DIC)
1980 • 24 citations
Prevention of Early Reocclusion after Thrombolysis of Copper Coil-induced Thrombi in the Canine Carotid Artery: Comparison of PEG-Hirudin and Unfractionated Heparin
1996 • 22 citations
Preparation of dextran-bound recombinant hirudin and its pharmacokinetic behaviour.
1990 • 17 citations
Accelerated thrombin generation during conjunctive treatment of myocardial-infarction with t-pa and r-hirudin (cgp-39-393)
1995 • 17 citations
Alteration of pharmacokinetics and pharmacodynamics of recombinant hirudin (rHV2-Lys 47) after repeated intravenous administration in dogs
1993 • 15 citations
Effect of Recombinant Hirudin (LU 52369) on Reocclusion Rates after Thrombolysis in Rabbits
1991 • 8 citations