3 The Pharmacology of Heparin and Heparinoids

Aliphatic Ammonium Salts in the Assay of Acidic Polysaccharides from Tissues

1960 • 679 citations

Systemic Mast Cell Disease

1988 • 485 citations

Ueber einen neuen Formbestandtheil des Blutes und dessen Rolle bei der Thrombose und der Blutgerinnung

1882 • 415 citations

TWO NEW FACTORS IN BLOOD COAGULATION—HEPARIN AND PRO-ANTITHROMBIN

1918 • 371 citations

THE INHIBITION OF BLOOD CLOTTING: AN UNIDENTIFIED SUBSTANCE WHICH ACTS IN CONJUNCTION WITH HEPARIN TO PREVENT THE CONVERSION OF PROTHROMBIN INTO THROMBIN

1939 • 235 citations

PROTEOLYTIC ENZYMES OF MAST CELLS*

1963 • 197 citations

Heparin Enhancement of Factors Stimulating Bone Resorption in Tissue Culture

1965 • 182 citations

STUDIES ON THE CHEMISTRY OF BLOOD COAGULATION

1937 • 176 citations

The Bacterial Factor in Traumatic Shock

1959 • 174 citations

PLATELET AGGLUTINATION AND VASOCONSTRICTION AS FACTORS IN SPONTANEOUS HEMOSTASIS IN NORMAL, THROMBOCYTOPENIC, HEPARINIZED AND HYPOPROTHROMBINEMIC RATS

1947 • 157 citations

The Elimination from Plasma of Intravenous Heparin An Experimental Study on Dogs and Humans

1963 • 148 citations

The identity and origin of the anticoagulant of anaphylactic shock in the dog

1941 • 143 citations

Studies on fractionated heparin

1961 • 112 citations

The nomenclature of mucopolysaccharides

1960 • 110 citations

Ion-exchange reactions between acid mucopolysaccharides and various cations

1962 • 107 citations

A method for the determination of heparin in blood

1949 • 106 citations

The uronic acid of heparin

1962 • 104 citations

The reaction of heparin with proteins and complex bases

1943 • 102 citations

Endothelial cells and “cement” lines

1959 • 99 citations

Pathogenesis of Fibrinolysis in Defibrination Syndrome: Effect of Heparin Administration

1964 • 96 citations

The Effect of Anticoagulant Therapy on Bone Repair

1956 • 95 citations

Silicones and blood coagulation.

1946 • 92 citations

Protective Action of Heparin in Experimental Immune Nephritis

1965 • 92 citations

STUDIES ON THE INHIBITION OF FIBRINOLYSIS BY LIPIDS

1957 • 85 citations

The inhibition of pancreatic ribonuclease by anionic polymers

1959 • 84 citations

The Inhibition of the Proteolytic Action of Pepsin by Sulfate-Containing Polysaccharides

1954 • 83 citations

Plasma Heparin Levels in Normal Man

1961 • 80 citations

CRITICAL REVIEW: THE MECHANISM OF HAEMOSTASIS

1941 • 79 citations

Heparin, 5-hydroxytryptamine, and histamine in neoplastic mast cells

1960 • 78 citations

Macromolecular properties and biological activity of heparin

1961 • 75 citations

The Tissue Mast Cell

1963 • 73 citations

The Effect of Heparin on Cell Division.

1949 • 71 citations

The action of thromboplastic substances

1953 • 70 citations

THE ISOLATION AND CRYSTALLIZATION OF PLANT VIRUSES AND OTHER PROTEIN MACRO MOLECULES BY MEANS OF HYDROPHILIC COLLOIDS

1942 • 66 citations

Analysis of the native heparin-lipoprotein complex including the identification of a heparin complement (heparin co-factor) obtained from extracts of tissue mast cells

1951 • 64 citations

TISSUE REACTIONS TO ANAPHYLACTIC AND ANAPHYLACTOID STIMULI; PROTEOLYSIS AND RELEASE OF HISTAMINE AND HEPARIN

1955 • 63 citations

Anticoagulant Activity of Human Arterial Mucopolysaccharides

1959 • 62 citations

THE BIOLOGICAL BEHAVIOUR OF A NEW SYNTHETIC ANTICOAGULANT (DEXTRAN SULPHATE) POSSESSING HEPARIN‐LIKE PROPERTIES

1952 • 60 citations

STUDIES ON ISOLATED CELL COMPONENTS

1951 • 60 citations

White Thrombo-embolism and Vascular Fragility in the Hamster Cheek Pouch after Anticoagulants

1953 • 57 citations

On the Determination of Heparin in Blood Plasma and Urine

1947 • 57 citations

THE USE OF HEPARIN AS AN ANTI-INFLAMMATORY AGENT

1960 • 56 citations

ON THE INHOMOGENEITY OF COMMERCIAL HEPARIN PREPARATIONS FROM THE PHYSICOCHEMICAL POINT OF VIEW

1948 • 56 citations

ANTIMITOTIC SUBSTANCES FROM OVARIES

1954 • 55 citations

ELECTROPHORETIC STUDY OF THE ACTION OF ALKYLBENZENESULFONATE DETERGENTS ON EGG ALBUMIN

1943 • 55 citations

Effects of heparin on experimental nephritis in rabbits.

1954 • 53 citations

Physiologic actions of heparin not related to blood clotting

1964 • 52 citations

The linkage of heparin to protein

1964 • 52 citations

Tissue Mast Cells and Tissue Amines

1959 • 50 citations

Two Disaccharides from Carboxyl-Reduced Heparin. The Linkage Sequence in Heparin¹

1964 • 50 citations

Über die Wirkung des Heparins auf das Wachstum von Gewebezellen in vitro

1936 • 49 citations

Transfer of radioactive sulfate from phosphoadenosine phosphosulfate to heparin

1959 • 49 citations

Studies on Lymphocytes. II. The Production of Lymphocytosis by Intravenous Heparin in Calves

1962 • 48 citations

The Natriuretic and Aldosterone-Suppressive Action of Heparin and Some Related Polysulfated Polysaccharides1

1964 • 47 citations

Structural Studies of Heparin. I. Hydrolytic Cleavage of Sulfates^*

1963 • 46 citations

The effect of heparin on the sticking of white cells to endothelium in inflammation

1962 • 45 citations

Prevention of Hormonal Eosinopenia and Lymphopenia by Inhibition of Clotting in Blood

1951 • 45 citations

Viscous Metamorphosis of Blood Platelets: A Study of the Relationship to Coagulation Factors and Fibrin Formation

1958 • 44 citations

Anticoagulants and the Development of Pulmonary Metastases

1962 • 43 citations

Heparin in the treatment of chronic obstructive bronchopulmonary disease

1964 • 43 citations

The Anionic Polyelectrolyte, Polyethylene Sulphonate, as a New Anti-neoplastic Agent

1958 • 42 citations

Die thromboembolischen Erkrankungen

1962 • 41 citations

POLYSACCHARIDES OF NEOPLASTIC MAST CELLS

1963 • 39 citations

THE EFFECT OF INTRAVENOUS INJECTIONS OF HEPARIN IN THE DOG

1938 • 38 citations

Antithormbin and Heparin

1943 • 38 citations

The growth-inhibitory action of heparin on the Ehrlich ascites tumor in mice.

1957 • 37 citations

Trivalent cation binding of acid mucopolysaccharides

1960 • 37 citations

Inhibition of Thrombocytopenia and 5-Hydroxytryptamine Release in Anaphylactic Shock by Heparin

1960 • 37 citations

THROMBOSIS AND ANTICOAGULANT THERAPY

1960 • 37 citations

Enhancement of Jejunal Absorption of Heparinoid by Sodium Ethylenediaminetetraacetate in the Dog.

1962 • 36 citations

Studies Made With Radioactive Heparin in Humans

1960 • 36 citations

The administration of heparin.

1938 • 36 citations

Heparin Inhibition of Anaphylactic Shock

1926 • 36 citations

Principles of general physiology

1918 • 35 citations

Bedeutung von Zink für die Histaminspeicherung in Mastzellen

1963 • 35 citations

The Estimation of Heparin and Similar Substances in Human Blood and Tissues Using a Combined Biological and Colorimetric Method with Paper Electrophoretic Studies

1954 • 35 citations

The structure of heparin proton magnetic resonance spectral observations

1966 • 34 citations

Side reactions of heparin in clinical practice

1964 • 34 citations

Clotting Time of Heparinized Blood

1964 • 34 citations

A new type of heparin “ω-heparin” isolated from whale organs

1964 • 33 citations

A COMPARISON OF THE HEPARINS OF VARIOUS MAMMALIAN SPECIES

1942 • 33 citations

THE RELATIONSHIP BETWEEN HEPARIN DOSAGE AND CLOTTING TIME

1948 • 33 citations

Heparin and the Antithrombic Activity of Plasma

1942 • 32 citations

Inhibition of peptic activity, protection against histamine ulceration in the guinea pig, and combination with gastric mucin by an algal polyanion.

1959 • 31 citations

Hydrolytic sensitivity of the sulfoamino group in heparin and in model compounds

1962 • 31 citations

Mechanism of Heparin Protection Against a Histamine Releasor (48/80).

1956 • 31 citations

THE EFFECT OF HEPARIN ON THE EARLY STAGES OF BLOOD COAGULATION

1960 • 30 citations

Heparin as a prophylactic against postoperative thrombosis

1941 • 30 citations

Effect of Acid Polysaccharides on the Fibrinolytic System in Guinea‐Pig Serum.

1959 • 30 citations

Über die chemische Natur des Heparins. II. Die Reindarstellung des Heparins.

1933 • 29 citations

The Metachromatic Activity of Urine Following the Injection of Heparin

1953 • 29 citations

The probable mechanism of heparin inhibition of mitosis

1952 • 28 citations

EXPERIMENTAL EXCHANGE TRANSFUSION USING PURIFIED HEPARIN

1938 • 28 citations

OBSERVATIONS ON THE EFFECTS OF A SERIES OF DEXTRAN SULPHATES OF VARYING MOLECULAR WEIGHT ON THE FORMED ELEMENTS OF THE BLOOD IN VITRO

1953 • 27 citations

Excretion pattern and mechanism of diuresis induced by heparin

1960 • 27 citations

ON THE POLYELECTROLYTE BEHAVIOR OF HEPARIN. I. BINDING OF SODIUM IONS

1961 • 26 citations

Heparin Precipitability of the Macroglobulin in a Patient with Waldenström's Macroglobulinemia

1960 • 26 citations

Stimulation by Heparin of Parenchymal Liver Cell Proliferation in Normal Adult Rats

1961 • 25 citations

The Comparative Protective Effects of Degraded Carrageenin and Aluminium Hydroxide on Experimentally Produced Peptic Ulceration

1959 • 25 citations

Activation of a globulin system controlling capillary permeability in inflammation

1957 • 25 citations

Interaction Between Fibrinogen and Polysaccharide Polysulfuric Acids

1946 • 25 citations

Function of Heparin

1955 • 25 citations

Some factors influencing the anticoagulant action of heparin

1940 • 24 citations

A Dextrorotatory Polysaccharide of Very High Anticoagulant Activity Newly Isolated From the Whale's Lung and Intestine

1963 • 23 citations

The Kinetics of the Inhibition of Lipoprotein Lipase by Polyanions and Polycations

1962 • 23 citations

Anticoagulant, Lipemia Clearing and Other Effects of Anionic Polysaccharides Extracted from Seaweed

1957 • 23 citations

Anti-Coagulants and Complementary Activity

1941 • 22 citations

Heparin in the Treatment of Toxemia of Pregnancy

1948 • 22 citations

Electrical Hemostasis in Uncontrollable Bleeding States

1961 • 21 citations

Heparin in Blood.

1957 • 21 citations

Further Studies on the Influence of Heparin on Anaphylactic Shock in the Guinea Pig

1928 • 20 citations

The binding of sodium and potassium ions by heparin

1963 • 20 citations

Further Studies With Serotonin and Experimental Pulmonary Embolism*

1960 • 20 citations

Absorption of Heparin from the Intestine.

1959 • 19 citations

STRESS AND MULTIPLE‐FACTOR ETIOLOGY OF BLEEDING*

1964 • 18 citations

Enzymic degradation of heparin

1956 • 18 citations

Coagulation studies on the electrophoretic fractions of AFIF

1962 • 18 citations

Stimulation of Cell Locomotion and Pseudopod Formation by Heparin

1962 • 17 citations

A quantitative method of assay for thrombin and prothrombin

1941 • 16 citations

On the smooth-muscle stimulating activity of preparations of heparin.

1961 • 16 citations

The Release of Histamine and Heparin by Antigen from the Isolated Perfused Liver of the Sensitized Dog

1949 • 16 citations

�ber einen tern�ren Heparin-Metall-Histamin-Komplex

1961 • 16 citations

The release of histamine and heparin by antigen from the isolated perfused liver of the sensitized dog.

1949 • 15 citations

Heparinoide Chemie und tierexperimentelle Prüfung

1961 • 14 citations

INFRARED SPECTROSCOPY OF THE WATER VAPOR SORPTION PROCESS OF MUCOPOLYSACCHARIDES

1963 • 14 citations

In Vivo Effect of Heparin on Acid and Alkaline Ribonuclease Activities of Mouse Liver

1956 • 14 citations

Nudibranch Spicules Made of Amorphous Calcium Carbonate

1951 • 14 citations

Heparin and the Agglutination of Platelets in Vitro.

1943 • 13 citations

Pharmacological Considerations of Antithrombotic Therapy

1962 • 13 citations

Unusual Action of Heparin on Ascites Tumour Cells during Freezing and Thawing

1964 • 13 citations

Vorkommen und Bedeutung des körpereigenen Heparins

1954 • 13 citations

The linkage sequence in heparin

1963 • 13 citations

Antagonismus zwischen Heparin und 5-Hydroxytryptamin (Serotonin)in vitro

1957 • 12 citations

Heparinic Acids: Determination of Equivalent Weights and Sulfate to Carboxyl Ratios

1964 • 12 citations

Effect of heparin on leukocyte response to hydrocortisone injections

1963 • 12 citations

Sur les réactions anaphylactiques des vaisseaux mésentériques du lapin

1956 • 12 citations

Permeabilizing Effects of Heparin and Heparin-like Substances

1958 • 12 citations

Pseudohypocalc�mie im heparinisierten Blut

1961 • 12 citations

Heparin and Thrombocytopenia in Experimental Burn Injuries

1961 • 12 citations

Demonstration of a heparin-like anticoagulant in normal blood. II. Horse blood.

1954 • 12 citations

Clearance of Injected Heparin from the Blood

1957 • 11 citations

The Autoclaving of Drugs for use at the Time of Intraocular Surgery*

1950 • 11 citations

EFFECT OF A LAMINARIN SULPHATE (LM 46) ON BONE GROWTH

1958 • 11 citations

[Anaphylactic reactions of mesenteric vessels of the rabbit].

1956 • 11 citations

Effect of Heparin on Artificial Activation in the Frog Egg.

1949 • 11 citations

The Toxicity of Synthetic Heparin Substitutes

1953 • 11 citations

Investigations on the chemistry of heparin. II. presence of a uronidic linkage with carbon-6 of glucosamine

1960 • 11 citations

THE BIOMEDICAL COMPUTING SECTION IN A GENERAL‐PURPOSE COMPUTING LABORATORY

1964 • 10 citations

Toxicity of Heparinoids, with Special Reference to the Precipitation of Fibrinogen

1964 • 10 citations

The Thromboplastic Activity of Hyaluronate

1951 • 10 citations

Die vasomotorische Wirkung von Heparin bei Normalen und bei an Raynaudscher Krankheit leidenden Patienten

1954 • 10 citations

Alkaline Earths in Heparin

1963 • 10 citations

�ber ein Komplement und Prothrombin mit besonderer Ber�cksichtigung der Antithrombotika 3,3?-methylen-di-(4-oxycumarin) und Heparin

1949 • 10 citations

Examination of the latex fixation test using sulfated mucopolysaccharides

1960 • 9 citations

«Bindung» eines synthetischen Polypeptides (Hypertensin) an Heparin und Freisetzung des Peptides durch Compound 48/80in vitro

1960 • 9 citations

MECHANISM OF ACTION OF HEPARIN AS AN ETIOLOGICAL BASIS FOR HOMEOSTASIS (HEMORRHAGE AND THROMBOSIS)

1955 • 9 citations

Förderung der gastrointestinalen Resorption von Heparin durch Calciumbindungsmittel

1963 • 9 citations

The lack of effect of heparin on mitosis in strain L cells.

1958 • 9 citations

Untersuchungen Über den Angriffspunkt von gerinnungshemmenden Stoffen am Komplement

1956 • 9 citations

ROLE OF VASODILATOR DRUGS IN CORONARY OCCLUSION

1949 • 8 citations

ISOLATION OF RAT HEPARIN

1959 • 8 citations

A Comparison of the Effect of Platelets and Erythrocytes on the Inhibitory Action of Blood Coagulation by Polybrene and Heparin

1964 • 8 citations

Studies on the Relationship between Anticoagulants and Hemolysis

1956 • 8 citations

STUDIES OF INHIBITORS OF BACTERIAL AND OTHER HYALURONIDASES II

1957 • 8 citations

CAPILLARY PERMEABILITY AND INFLAMMATION IN RABBITS GIVEN HEPARIN

1941 • 8 citations

Heparin Suppression of Gastric Acid Secretion.

1963 • 8 citations

Anticoagulant Therapy

1964 • 8 citations

Weitere Untersuchungen über die Pigmentgenese

1952 • 7 citations

HEPARIN-INDUCED BLOCK OF THE LEUKOCYTE RESPONSE TO CORTISONE1

1957 • 7 citations

�ber die Wirkung von Heparin auf den experimentellen Hochdruck bei Ratten

1955 • 7 citations

REVERSAL OF SEROLOGIC REACTIONS BY HEPARIN: THERAPEUTIC IMPLICATIONS. II. IDIOPATHIC ACQUIRED HEMOLYTIC ANEMIA (IAHA).

1964 • 7 citations

REVERSAL OF SEROLOGIC REACTIONS BY HEPARIN: THERAPEUTIC IMPLICATIONS. I. SYSTEMIC LUPUS ERYTHEMATOSUS.

1964 • 6 citations

Hypercoagulability Syndrome Due to Heparin Co-Factor Deficiency

1964 • 6 citations

The effect of heparin and its components on frog heart

1963 • 6 citations

Gerinnungsaktivit�t und Toxicit�t bei Heparinen und Heparinoiden

1957 • 6 citations

Measurement of the Inhibitory Action of Anticoagulants

1938 • 6 citations

Practical application of the heparin-caronamide reaction to the potentiation of heparin in gelatin menstruum.

1948 • 5 citations

Release of Histamine in Hepatectomized Dogs during Anaphylactic, Peptone and Tryptic Shock

1955 • 5 citations

Heparin as a source of error in the determination of plasma albumin on a basis of selective dye-binding

1962 • 5 citations

Thromboembolic Conditions and Their Treatment with Anticoagulants

1951 • 5 citations

Dosiswirkungsrelation von N-Formyl-chitosan-poly-schwefelsäureester (Ro 1-8307) hinsichtlich Klärfaktoraktivierung und Gerinnungshemmung im Vergleich mit Heparin im Tierversuch und am Menschen

1959 • 5 citations

New data on the physico-chemical properties of heparin

1951 • 4 citations

Attempts to Prepare Heparin from Ox Liver Capsules with a Mild Method.

1959 • 4 citations

Die Wirkung hochmolekulärer Esterschwefelsäuren (Heparin und Chondroitinschwefelsäure) auf das Wachstum der Kaulquappe

1938 • 4 citations

Beiträge zur Reversibilität einiger Seruineiweiss-Reaktionen durch Heparin

1959 • 4 citations

SOME OF THE DETOXIFYING PROPERTIES OF HEPARIN

1944 • 4 citations

Heparin and the Water Metabolism with Special Reference to the ADH

1963 • 4 citations

Distribution of Injected Heparin in Different Blood Fractions.

1959 • 4 citations

Wirkung von Polysacchariden bakterieller Herkunft auf die experimentelle Lipämie

1957 • 4 citations

THE INFLUENCE OF HEPARIN ON ALLERGIC CUTANEOUS TESTS FOR ALLERGIC ASTHMA.

1964 • 4 citations

Heparin requirement during dialysis with the parallel flow, straight tube blood dialyzer (MacNeill-Collins)

1964 • 3 citations

The effect of heparin on the arginine (BAEE) esterase activity of blood.

1962 • 3 citations

The Disappearance of Heparin Activity with Liver Globulins and Determinations of Heparinase

1963 • 3 citations

HEPARIN TREATMENT OF BLEEDING DUE TO PRIMARY HYPERCOAGULABILITY.

1963 • 3 citations

The Effect of Mechanical Trauma on Fibrinogen in Heparinized Blood

1960 • 3 citations

Effect of heparin pretreatment on stress-induced adrenal ascorbic acid changes in the rat

1956 • 3 citations

INDUCED COAGULATION OF HEPARINISED BLOOD

1964 • 3 citations

Untersuchungen über die Heparinwirkung am histaminkontrahierten Meerschweinchen-Ileum

1956 • 3 citations

Über die pharmakologie wasserlöslicher polysaccharide und ihrer derivate in abhängigkeit von molekülgröße, molekülgestalt und art der substituenten

1954 • 2 citations

Effect of Histamine and Antihistaminics on Coagulation of Normal and Heparinized Rabbit Plasma

1951 • 2 citations

Klinische Erfahrungen mit einem neuen Sulfamyl-Diureticum (G 33182 – Chlorthalidon)

1961 • 2 citations

Researches on Complement. III. Action of Sulphuric Esters of Polysaeeharides; Antagonistic Effect of Basic Dyes.

1948 • 2 citations

Protaminsulfat als Haemostypticum bei Lungenblutungen

1959 • 2 citations

Effects of heparin, treburon, dicoumarol and tromexan on blood vessels.

1959 • 2 citations

Vergleich der blutgerinnungs-hemmenden und hyaluronidase-hemmenden Wirkung von Xylan-Schwefelsäureestern und Heparin

1955 • 2 citations

The Theory and Practice of Anticoagulant Treatment

1964 • 1 citations

The Effect of Intravascular Injection of Glucose and Heparin on the Heart Electrogram in Acutely Chilled Frogs and Toads

1960 • 1 citations

EFFECT OF HEPARIN ON ISCHEMIC COMPRESSION SHOCK

1947 • 1 citations

Preparation of a Sulfated Mucopolysaccharide

1962 • 1 citations

Effect of heparin on malignant tumor cells in tissue culture

1964 • 1 citations

Inhibition of Fibrinoid Deposition by Heparin

1961 • 1 citations

[The experimental mast cell].

1958 • 1 citations

Effect of Protamine Sulfate in Neutralizing Coagulation Defect Produced by Paritol.

1952 • 1 citations

Selektive Einschleusung von Evans-blue in Tumorzellen durch Heparinoid

1963 • 1 citations

A Clinical Study of a New Heparinoid

1963 • 1 citations