Molecular Genetics of Aging

Intracellular Protein Degradation in Mammalian and Bacterial Cells

1974 • 1,775 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells: Part 2

1976 • 1,060 citations

THE MAINTENANCE OF THE ACCURACY OF PROTEIN SYNTHESIS AND ITS RELEVANCE TO AGEING

1963 • 950 citations

ON THE NATURE OF THE AGING PROCESS

1959 • 620 citations

Ageing of Clones of Mammalian Cells

1973 • 409 citations

Altered Enzymes in Ageing Human Fibroblasts

1972 • 408 citations

The Importance of Both Synthesis and Degradation in the Control of Arginase Levels in Rat Liver

1964 • 396 citations

Protein Turnover in Skeletal Muscle

1969 • 317 citations

ON THE INFLUENCE OF FOOD AND TEMPERATURE UPON THE DURATION OF LIFE

1917 • 268 citations

Ageing : the biology of senescence

1964 • 253 citations

The Regulation of Physiological Changes During Mammalian Aging

1976 • 245 citations

Detection of Inactive Enzyme Molecules in Ageing Organisms

1970 • 220 citations

Acetyl Coenzyme A Carboxylase

1969 • 218 citations

Essays upon heredity and kindred biological problems /

1892 • 211 citations

The maintenance of the accuracy of protein synthesis and its relevance to ageing: a correction.

1970 • 201 citations

The Dynamics of Synthesis and Degradation of Polyamines in Normal and Regenerating Rat Liver and Brain

1970 • 189 citations

Intrinsic Mutagenesis: A Genetic Basis of Ageing

1974 • 180 citations

Intrinsic Mutagenesis: A Genetic Approach to Ageing.

1975 • 177 citations

Hypertrophy versus Hyperplasia

1966 • 150 citations

Protein Turnover in Skeletal Muscle. II. The Effect of Starvation and a Protein-Free Diet on the Synthesis and Catabolism of Skeletal Muscle Proteins in Comparison to Liver

1970 • 147 citations

Inactive Enzyme Molecules in Aging Mice: Liver Aldolase

1973 • 131 citations

Advances in gerontological research

1968 • 116 citations

Auto-immune Disease: II. Pathology of the Immune Response

1959 • 115 citations

Inactive enzyme molecules in aging organisms. Nematode fructose 1,6-diphosphate aldolase

1973 • 114 citations

Auto-immune Disease: I. Modern Immunological Concepts

1959 • 113 citations

Enzyme activities, gene function and ageing in mammals (review)

1972 • 101 citations

Advances in gerontological research

1972 • 95 citations

Somatic Mutation and Chronic Disease

1965 • 94 citations

Enzyme Changes in Ageing Mammals

1973 • 85 citations

Age-related changes in membrane lipid content and enzyme activities

1972 • 78 citations

Aging: The Biology of Senescence

2000 • 77 citations

Chromosome Aberrations in Liver Cells in Relation to the Somatic Mutation Theory of Aging

1963 • 74 citations

Altered enzyme molecules in senescent organisms: mouse muscle aldolase

1973 • 72 citations

Senescence and the Fidelity of Protein Synthesis in Drosophila

1967 • 63 citations

Relationship between DNA Repair Capacity and Cellular Aging

1976 • 63 citations

Long-term effects of a single whole-body exposure of mice to ionizing radiations I. Life-shortening

1961 • 56 citations

Age Differences in the Succinoxidase Activity of Homogenates and Mitochondria from The Livers and Kidneys of Rats

1960 • 46 citations

Essays upon heredity and kindred biological problems, by Dr. August Weismann ... Ed. by Edward B. Poulton ... Selmar Schönland ... and Arthur E. Shipley...Authorised translation

1891 • 45 citations

A modified mouse liver chromatin preparation displaying age-related differences in salt dissociation and template ability

1972 • 43 citations

Protein synthesis, development, growth and life span.

1975 • 38 citations

Lactate dehydrogenase isoenzymes. Turnover in rat heart, skeletal muscle, and liver

1973 • 37 citations

A Model for Aging Based on Differential Repair of Somatic Mutational Damage

1974 • 29 citations

Experiments on Longevity

1928 • 29 citations

Genetic control of adult life span in Drosophila melanogaster

1970 • 27 citations

Testing the Protein Error Theory of Ageing: A Reply to Baird, Samis, Massie and Zimmerman

1975 • 26 citations

The relationship of γ-aminobutyrate levels and its metabolism to age in brains of mice

1973 • 26 citations

In vivo turnover and its role in the metabolic regulation of enzyme levels.

1968 • 26 citations

Nutrition, aging, and genetic program

1972 • 21 citations

Long-term effects of a single whole-body exposure of mice to ionizing radiation. I. Life-shortening

1961 • 20 citations

Failures of regulation mechanisms as causes of cellular aging.

1971 • 20 citations

THE PROGRAMMED THEORY OF AGING

1974 • 20 citations

A Brief Argument in Opposition to the Orgel Hypothesis

1975 • 17 citations

Test for missynthesis of lactate dehydrogenase in aging mice by use of a monospecific antibody

1973 • 16 citations

Senescence as an Adaptive Trait

1969 • 16 citations

A concept of biological aging: The role of compensatory processes

1966 • 16 citations

Biological Effects of Gamma Irradiation (Series II)

1939 • 14 citations

RADIATION INDUCED AGING IN MICE

1958 • 14 citations

Cybernetics and Aging

1967 • 9 citations

Evolution and Mortality

1928 • 7 citations

A further Note on the Orgel Error Hypothesis and Senescence

1975 • 5 citations

Epilogue

1967 • 1 citations