The functional subunit of a dimeric transcription activator protein depends on promoter architecture.

Experiments in molecular genetics

1972 • 28,260 citations

Crystal Structure of a CAP-DNA Complex: the DNA Is Bent by 90°

1991 • 1,109 citations

TRANSCRIPTIONAL REGULATION BY cAMP AND ITS RECEPTOR PROTEIN

1993 • 819 citations

A Third Recognition Element in Bacterial Promoters: DNA Binding by the α Subunit of RNA Polymerase

1993 • 790 citations

Structure of a complex of catabolite gene activator protein and cyclic AMP refined at 2.5 Å resolution

1987 • 478 citations

Selection of DNA binding sites by regulatory proteins

1988 • 364 citations

Transcription activation at Class I CAP‐dependent promoters

1993 • 350 citations

Bipartite functional map of the E. coli RNA polymerase α subunit: Involvement of the C-terminal region in transcription activation by cAMP-CRP

1991 • 346 citations

Stringent spacing requirements for transcription activation by CRP

1990 • 265 citations

Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli

1984 • 241 citations

Mechanism of CRP-cAMP activation of lac operon transcription initiation activation of the P1 promoter

1984 • 228 citations

Evidence of DNA Bending in Transcription Complexes Imaged by Scanning Force Microscopy

1993 • 199 citations

Consensus DNA site for theEscherichia colicatabolite gene activator protein (CAP): CAP exhibits a 450-fold higher affinity for the consensus DNA site than for theE.coli lacDNA site

1989 • 178 citations

Mutations that alter the ability of theEscherichia colicyclic AMP receptor protein to activate transcription

1990 • 174 citations

Identification of the Target of a Transcription Activator Protein by Protein-Protein Photocrosslinking

1994 • 166 citations

Use of mono Q high resolution ion exchange chromatography to obtain highly pure and active Escherichia coli RNA polymerase

1990 • 155 citations

Identification of the activating region of catabolite gene activator protein (CAP): isolation and characterization of mutants of CAP specifically defective in transcription activation.

1993 • 146 citations

Helical phase dependent action of CRP: effect of the distance between the CRP site and the −35 region on promoter activity

1990 • 142 citations

DNA sequence determinants for binding of the Escherichia coli catabolite gene activator protein.

1992 • 130 citations

Functional map of the alpha subunit of Escherichia coli RNA polymerase: two modes of transcription activation by positive factors.

1991 • 122 citations

Mapping the cAMP receptor protein contact site on the α subunit of Escherichia coli RNA polymerase

1992 • 113 citations

Synergy between Escherichia coli CAP protein and RNA polymerase in the lac promoter open complex

1989 • 110 citations

Escherichia coli catabolite gene activator protein mutants defective in positive control of lac operon transcription

1991 • 103 citations

E.coliRNA polymerase, deleted in the C-terminal part of its α-subunit, interacts differently with the cAMP-CRP complex at thelacP1 and at thegaP1 promoter

1993 • 94 citations

Role of glutamic acid-181 in DNA-sequence recognition by the catabolite gene activator protein (CAP) of Escherichia coli: altered DNA-sequence-recognition properties of [Val181]CAP and [Leu181]CAP.

1987 • 89 citations

The role of two surface exposed loops in tranction activation by theEscherichia ColiCRP and FNR proteins

1991 • 88 citations

Identification of the functional subunit of a dimeric transcription activator protein by use of oriented heterodimers

1993 • 77 citations

Interactions between the Escherichia coli cyclic AMP receptor protein and RNA polymerase at Class II promoters

1993 • 67 citations

Upstream curved sequences influence the initiation of transcription at the Escherichia coli galactose operon

1992 • 62 citations

Conversion of a helix-turn-helix motif sequence-specific DNA binding protein into a site-specific DNA cleavage agent.

1990 • 62 citations

Regulation of open complex formation at the Escherichia coli galactose operon promoters

1992 • 58 citations

Determination of the orientation of a DNA binding motif in a protein-DNA complex by photocrosslinking.

1992 • 47 citations

Derivatives of CAP Having No Solvent-Accessible Cysteine Residues, or Having a Unique Solvent-Accessible Cysteine Residue at Amino Acid 2 of the Helix-Turn-Helix Motif

1991 • 42 citations

Mutants of the lac promoter with large insertions and deletions between the CAP binding site and the −35 region

1984 • 41 citations

Modulation of the stability of a gene-regulatory protein dimer by DNA and cAMP.

1989 • 39 citations

Use of “Loss-of-Contact” Substitutions to Identify Residues Involved in an Amino Acid-Base Pair Contact: Effect of Substitution of Gln18 of Lac Repressor by Gly, Ser, and Leu

1985 • 39 citations

Catabolite gene activator protein (CAP) is not an “acidic activating region” transcription activator protein. Negatively charged amino acids of CAP that are solvent-accessible in the CAP-DNA complex play no role in transcription activation at the lac promoter.

1992 • 29 citations

The Structure of the RNA Polymerase-Promoter Complex

1994 • 23 citations

Phenyl-azide-mediated Photocrosslinking Analysis of Cro-DNA Interaction

1993 • 20 citations