The X chromosome shows less genetic variation at restriction sites than the autosomes.

Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

1980 • 8,270 citations

Molecular basis of base substitution hotspots in Escherichia coli

1978 • 1,185 citations

Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.

1978 • 804 citations

Restriction sites containing CpG show a higher frequency of polymorphism in human DNA

1984 • 586 citations

DNA sequence variants in the Gγ-, Aγ-, δ- and β-globin genes of man

1979 • 464 citations

A strategy to reveal high-frequency RFLPs along the human X chromosome.

1984 • 361 citations

Ancient Linkage Groups and Frozen Accidents

1973 • 338 citations

An estimate of unique DNA sequence heterozygosity in the human genome

1985 • 297 citations

Cloning of a representative genomic library of the human X chromosome after sorting by flow cytometry

1981 • 277 citations

Report of the committee on human gene mapping by recombinant DNA techniques

1984 • 274 citations

Genetic mapping and diagnosis of haemophilia A achieved through a BclI polymorphism in the factor VIII gene

1985 • 231 citations

Isolation of probes detecting restriction fragment length polymorphisms from X chromosome-specific libraries: potential use for diagnosis of Duchenne muscular dystrophy

1985 • 217 citations

Regional localization on the human X of DNA segments cloned from flow sorted chromosomes

1982 • 191 citations

DNA restriction fragment length polymorphisms and heterozygosity in the human genome

1984 • 147 citations

Unusual scarcity of restriction site polymorphism in the human thyroglobulin gene. A linkage study suggesting autosomal dominance of a defective thyroglobulin allele

1984 • 119 citations

The occurrence of new mutants in the X-linked recessive Lesch-Nyhan disease.

1976 • 109 citations

Estimation of genetic variation at the DNA level from restriction endonuclease data.

1981 • 100 citations

Linkage disequilibrium and evolutionary relationships of DNA variants (restriction enzyme fragment length polymorphisms) at the serum albumin locus.

1984 • 79 citations

Strategies for detecting and characterizing restriction fragment length polymorphisms (RFLP's).

1982 • 77 citations

Molecular cloning and DNA sequence analysis of genes encoding cytotoxic T lymphocyte-defined HLA-A3 subtypes: the E1 subtype.

1985 • 42 citations

Separation and analysis of human chromosomes by combined velocity sedimentation and flow sorting applying single‐ and dual‐laser flow cytometry

1984 • 30 citations

A study of restriction fragment length polymorphisms at the human alpha-1-antitrypsin locus

1985 • 25 citations

Optimizing selection of restriction enzyme in the search for ONA variants

1984 • 23 citations