Methyltransferase Enzymes in the Metabolism of Physiologically Active Compounds and Drugs

Enzymatic O-Methylation of Epinephrine and Other Catechols

1958 • 1,291 citations

Regional Neurochemistry

1962 • 815 citations

Purification and Properties of Phenylethanolamine-N-methyl Transferase

1962 • 620 citations

Control of Enzymatic Synthesis of Adrenaline in the Adrenal Medulla by Adrenal Cortical Steroids

1966 • 558 citations

STRUCTURE OF MELATONIN¹

1959 • 443 citations

Melatonin Synthesis in the Pineal Gland: Control by Light

1963 • 430 citations

Enzymatic O-Methylation of N-Acetylserotonin to Melatonin

1960 • 427 citations

Purification and Properties of Hydroxyindole-O-methyl Transferase

1961 • 409 citations

The Distribution and Properties of a Histamine-methylating Enzyme

1959 • 371 citations

O-Methylation of Epinephrine and Other Catechols in vitro and in vivo

1957 • 359 citations

3-Methoxy-4-hydroxy-D-mandelic acid, a urinary metabolite of norepinephrine

1957 • 351 citations

Melatonin Synthesis in the Pineal Gland: Effect of Light Mediated by the Sympathetic Nervous System

1964 • 284 citations

Fate of Tritiated Noradrenaline at the Sympathetic Nerve-Endings

1961 • 271 citations

Retinal and pineal hydroxyindole-o-methyl transferase activity in vertebrates

1965 • 243 citations

ACTIVATION OF METHIONINE FOR TRANSMETHYLATION

1951 • 198 citations

The formation of adrenaline from noradrenaline

1957 • 194 citations

The enzymic cleavage of aromatic ethers

1956 • 192 citations

METHYLATION OF NICOTINAMIDE WITH A SOLUBLE ENZYME SYSTEM FROM RAT LIVER

1951 • 187 citations

The enzymatic N-methylation of serotonin and other amines.

1962 • 184 citations

Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds

1961 • 178 citations

ACTIVATION OF METHIONINE FOR TRANSMETHYLATION

1957 • 165 citations

Pituitary Gland: Enzymic Formation of Methanol from S -Adenosylmethionine

1965 • 159 citations

STIMULATION OF C ¹⁴ -MELATONIN SYNTHESIS FROM C ¹⁴ -TRYPTOPHAN BY NORADRENALINE IN RAT PINEAL IN ORGAN CULTURE

1969 • 153 citations

Metabolism of norepinephrine-H3 released by tyramine and reserpine.

1962 • 149 citations

Inhibitor of O-Methylation of Epinephrine and Norepinephrine in vitro and in vivo

1959 • 148 citations

Inhibitory effects of beta-diethylaminoethyl diphenylpropylacetate on a variety of drug metabolic pathways in vitro.

1954 • 143 citations

Melatonin Synthesis in the Hen Pineal Gland and its Control by Light

1964 • 129 citations

ENZYMATIC MECHANISM OF CREATINE SYNTHESIS

1954 • 117 citations

Dynamic Aspects of Enzymatic O-Methylation and -Demethylation of Catechols in Vitro and in Vivo

1960 • 113 citations

ON THE MORPHOLOGY AND ADRENALINE-NORADRENALINE CONTENT OF CHROMAFFIN TISSUE

1953 • 106 citations

Norepinephrine Methylation in Fetal Rat Adrenals

1966 • 103 citations

Enzymatic conversion of norepinephrine to epinephrine by the brain.

1969 • 97 citations

Enzymatic p-O-Methylation by Catechol O-Methyl Transferase

1959 • 96 citations

Inhibition of O-Methyltransferase by Catechol and Sensitization to Epinephrine

1959 • 83 citations

THE METABOLISM OF HISTAMINE IN VARIOUS SPECIES

1956 • 83 citations

Indole(ethyl)amine N -Methyltransferase in the Brain

1969 • 81 citations

Occupancy of Adrenergic Receptors and Inhibition of Catechol O-Methyl Transferase by Tropolones^1,2

1963 • 81 citations

Formation and catabolism of histamine in cat brain in vivo

1960 • 80 citations

Development of HYDROXYINDOLE-O-methyl transferase activity in eye and brain of the amphibian,

1965 • 79 citations

Changes in the Enzymatic Synthesis of Melatonin in the Pineal During the Estrous Cycle

1965 • 76 citations

Factors affecting the enzymatic formation of o-methylated dihydroxy derivatives

1965 • 74 citations

Heterogeneity of N-and O-methyltransferases.

1970 • 74 citations

O-methylation in the conversion of tyrosine to melanin

1963 • 73 citations

Enzyme reactions with phenolic compounds: a meta-O-methyltransferase in plants

1963 • 73 citations

Alkaloids and Plant Metabolism

1963 • 69 citations

Enzymatic Synthesis of Melatonin in Avian Pineal Body: Extraretinal Response to Light

1968 • 67 citations

Sex differences and hormonal control of histamine methyltransferase activity

1965 • 62 citations

Species Differences in Inducibility of Phenylethanolamine-N-Methyl Transferase

1968 • 61 citations

Alkaloids and Plant Metabolism

1963 • 61 citations

Effect of drugs on the accumulation and metabolism of extraneuronal norepinephrine in the rat heart.

1967 • 61 citations

THE METHYLATION OF NORADRENALINE BY MINCED SUPRARENAL TISSUE

1949 • 60 citations

THE DISPOSITION OF CATECHOLAMINES IN THE RAT UTERUS AND THE EFFECT OF DRUGS AND HORMONES.

1964 • 60 citations

Synthesis of Serotonin by Pineal Glands of the Rat in Organ Culture

1967 • 58 citations

Enzymatic Synthesis of the Skin-lightening Agent, Melatonin, in Amphibians

1965 • 57 citations

Catechol-o-methyltransferase in nerve endings of rat brain

1965 • 53 citations

Catechol-O-methyl transferase and monoamine oxidase activities in the heart and liver of the embryonic and developing chick.

1968 • 53 citations

Biliary and Urinary Excretion of Metabolites of 7-H3-Epinephrine in the Rat

1962 • 51 citations

THE ORIGIN OF THE METHYL GROUP OF EPINEPHRINE

1950 • 50 citations

Neuronally dependent induction of adrenal phenylethanolamine-N-methyltransferase by 6-hydroxydopamine

1970 • 48 citations

Alkaloids and Plant Metabolism

1963 • 46 citations

Substrate specificity of phenethanolamine N-methyl transferase

1965 • 45 citations

Catecholamines and methyltransferases in the South American toad (Bufo marinus)

1962 • 43 citations

Phenol-O-methyltransferase

1968 • 41 citations

The Role of Cations in Non-enzymatic and Enzymatic O-Methylations of Catechol Derivatives

1962 • 39 citations

Purification and properties of catechol-O-methyltransferase

1968 • 38 citations

Hydroxyindole-O-methyltransferase in several avian species

1968 • 38 citations

Cardiac catechol O-methyltransferase and monoamine oxidase activity in congestive heart failure

1968 • 36 citations

Synthese von Catechol-O-methyl-transferase-hemmenden Verbindungen. In den Catecholaminmetabolismus eingreifende Substanzen. 1. Mitteilung

1962 • 36 citations

Demonstration of Hydroxyindole-O-methyl Transferase, Melatonin, and Serotonin in a Metastatic Parenchymatous Pinealoma

1964 • 33 citations

Increased biosynthesis of cardiac norepinephrine after hypophysectomy.

1969 • 31 citations

Inhibition of phenylethanolamine-N-methyl transferase

1967 • 29 citations

Viral Neoplastic Transformation of Hamster Pineal Cells in vitro: Retention of Enzymatic Function

1966 • 25 citations

Hydroxyindole-O-methyltransferase II. Inhibitory Activities of Some N-Acyltryptamines

1968 • 23 citations

Inhibition of histamine methylation in vivo by drugs

1964 • 22 citations

Catechol-O-Methyltransferase Activity in Neuroblastoma Tumour

1962 • 20 citations

Enzymic O-Methylation of Iodinated Phenols and Thyroid Hormones

1964 • 20 citations

Catechol O-Methyl Transferase in Skin**From the Section of Dermatology, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.

1964 • 19 citations

Inhibition of catechol-o-methyl transferase by some acid degradation products of adrenaline and noradrenaline

1967 • 15 citations

Enzymatic N-O-methylation of hydroxamic acids

1968 • 8 citations

Catecholamine metabolism in elasmobranch interrenal body

1968 • 8 citations

The enzymic conversion of adenine to 3-methyladenine

1962 • 7 citations