Effect of Structural Modifications on the Biological Properties of Aminoglycoside Antibiotics Containing 2-Deoxystreptamine

The Molecular Basis of Antibiotic Action

1981 • 1,237 citations

Streptomycin, a Substance Exhibiting Antibiotic Activity Against Gram-Positive and Gram-Negative Bacteria.*

1944 • 1,046 citations

Aminoglycoside Antibiotic-Inactivating Enzymes in Actinomycetes Similar to Those Present in Clinical Isolates of Antibiotic-Resistant Bacteria

1973 • 497 citations

Antibiotic and Chemotherapy

1965 • 433 citations

Neomycin, a New Antibiotic Active against Streptomycin-Resistant Bacteria, including Tuberculosis Organisms

1949 • 356 citations

Mechanisms of antibiotic resistance in bacteria.

1987 • 340 citations

BB-K8, A NEW SEMISYNTHETIC AMINOGLYCOSIDE ANTIBIOTIC

1972 • 328 citations

The Molecular Basis of Antibiotic Action

1973 • 298 citations

Gentamicin,¹ a New Antibiotic Complex from Micromonospora

1963 • 246 citations

AMA Drug Evaluations

1974 • 228 citations

Mechanism of Streptomycin Action on Bacteria: A Unitary Hypothesis

1961 • 227 citations

STREPTOMYCIN ACTION AND THE RIBOSOME

1964 • 186 citations

STUDIES ON THE RIBOSOMES OF STREPTOMYCIN-SENSITIVE AND RESISTANT STRAINS OF ESCHERICHIA COLI

1964 • 182 citations

PAROMOMYCIN. I. PAROMAMINE, A GLYCOSIDE OF D-GLUCOSAMINE¹

1959 • 168 citations

3'', 4''-DIDEOXY-KANAMYCIN B ACTIVE AGAINST KANAMYCIN-RESISTANT ESCHERICHIA COLI AND PSEUDOMONAS AERUGINOSA

1971 • 165 citations

Index of antibiotics from actinomycetes

1968 • 162 citations

Antibiotic inhibitors of the bacterial ribosome

1968 • 155 citations

R‐factor mediated gentamicin resistance: A new enzyme which modifies aminoglycoside antibiotics

1971 • 153 citations

Enzymic acetylation of aminoglycoside antibiotics by Excherichia coli carrying an R factor

1971 • 151 citations

Aminoglycoside Antibiotics: Inactivation by Phosphorylation inEscherichia coliCarrying R Factors

1969 • 143 citations

Phosphorylative Inactivation of Aminoglycosidic Antibiotics by Escherichia coli Carrying R Factor

1967 • 133 citations

Comparative pharmacokinetics of tobramycin and gentamicin

1973 • 126 citations

ANTIBIOTIC 6640, A NEW MICROMONOSPORA-PRODUCBD AMINOGLYCOSIDE ANTIBIOTIC

1970 • 125 citations

Inhibition of polypeptide synthesis by streptomycin

1962 • 116 citations

Activity of BB-K8 (Amikacin) Against Clinical Isolates Resistant to One or More Aminoglycoside Antibiotics

1974 • 115 citations

Inhibition of Protein Synthesis by Spectinomycin

1965 • 115 citations

Gentamicin resistance in strains of Pseudomonas aeruginosa mediated by enzymic N-acetylation of the deoxystreptamine moiety

1972 • 113 citations

Mechanism of Resistance to Antibiotic Synergism in Enterococci

1971 • 108 citations

Structure-Activity Relationships Among the Aminoglycoside Antibiotics: Role of Hydroxyl and Amino Groups

1973 • 105 citations

Enzymatic Inactivation of Streptomycin by R Factor-resistant Escherichia coli

1968 • 102 citations

Colonization with Gentamicin-Resistant Pseudomonas aeruginosa, Pyocine Type 5, in a Burn Unit

1971 • 89 citations

Serratia marcescens : Biochemical, Serological, and Epidemiological Characteristics and Antibiotic Susceptibility of Strains Isolated at Boston City Hospital

1970 • 86 citations

A Comparative Study of the Ototoxicity of Tobramycin and Gentamicin

1972 • 82 citations

Enzymatic Acetylation as a Means of Determining Serum Aminoglycoside Concentrations

1973 • 73 citations

The Isolation of a Second Antibiotic from Streptomyces hygroscopicus

1958 • 72 citations

ADENYL YLSTREPTOMYCIN, A PRIDUCT OF STREPTOMYCIN INACTIVATED BY E.COLI CARRYING R FACTOR

1968 • 71 citations

Comparative Tests of Gentamicin Ototoxicity

1969 • 70 citations

A Virulent Nosocomial Klebsiella with a Transferable R Factor for Gentamicin: Emergence and Suppression

1971 • 70 citations

DEVELOPMENT OF STREPTOMYCIN RESISTANCE DURING TREATMENT

1946 • 68 citations

STUDIES ON ANTIBIOTIC SF-733, A NEW ANTIBIOTIC. II

1970 • 68 citations

STUDIES ON ADENYLYLSTREPTOMYCIN, A PRODUCT OF STREPTOMYCIN INACTIVATION BY E. COLI CARRYING THE R-FACTOR

1968 • 68 citations

Butirosin, a New Aminoglycosidic Antibiotic Complex: Isolation and Characterization

1972 • 65 citations

Biological activity of the antibiotic components of the gentamicin complex

1967 • 64 citations

Inactivation of Kanamycin, Neomycin, and Streptomycin by Enzymes Obtained in Cells of Pseudomonas aeruginosa

1968 • 61 citations

Chemistry of the Neomycins. XII¹ The Absolute Configuration of Deoxystreptamine in the Neomycins, Paromomycins and Kanamycins

1963 • 60 citations

Aminoglycoside resistance in bacteria mediated by gentamicin acetyltransferase II, an enzyme modifying the 2'-amino group of aminoglycoside antibiotics

1974 • 58 citations

Mechanisms and Spectrum of Streptomycin Resistance in a Natural Population of Pseudomonas aeruginosa

1972 • 58 citations

Resistance Factor-mediated Streptomycin Resistance

1969 • 57 citations

SYNTHESIS OF 3''-DEOXYKANAMYCIN EFFECTIVE AGAINST KANAMYGIN-RESISTANT ESCHERICHIA COLI AND PSEUDOMONAS AERUGINOSA

1971 • 57 citations

The Neomycins and Related Antibiotics.

1964 • 57 citations

A NEW ENZYME IN ESCHERICHIA COLI CARRYING R-FAGTOR PHOSPHORYLATING 3''-HYDROXYL OF BUTIROSIN A, KANAMYCIN, NEAMINE AND RIBOSTAMYGIN

1972 • 56 citations

Streptomycin–Origin, Nature, and Properties*††Journal Series Paper of the Department of Microbiology of the New Jersey Agricultural Experiment Station, Rutgers University.

1945 • 56 citations

KANAMYCIN PHOSPHOTRANSFERASE I: MECHANISM OF CROSS RESISTANCE BETWEEN KANAMYCIN AND LIVIDOMYCIN

1973 • 56 citations

Polyribosome depletion and blockage of the ribosome cycle by streptomycin in Escherichia coli

1969 • 56 citations

ISOLATION OF KANAMYCIN AND PAROMAMINE INACTIVATED BY E. COLI CARRYING R FACTOR

1968 • 56 citations

ANTIBIOTIC 6640. III

1970 • 55 citations

PHOSPHORYLATION AND INACTIVATION OF AMINOGLYCOSIDIC ANTIBIOTICS BY E. COLI CARRYING R FACTOR

1968 • 55 citations

Mechanism of Inhibition of Ribosomes by Streptomycin

1969 • 53 citations

Butirosins A and B, aminoglycoside antibiotics. III. Structures

1971 • 53 citations

Serratia marcescens: Biochemical, Serological, and Epidemiological Characteristics and Antibiotic Susceptibility of Strains Isolated at Boston City Hospital

1970 • 51 citations

Resistance of Gram-Negative Bacilli to Gentamicin

1971 • 50 citations

NOSOCOMIAL INFECTIONS DUE TO KANAMYCIN-RESISTANT, [R]-FACTOR CARRYING ENTERIC ORGANISMS IN AN INTENSIVE CARE NURSERY

1972 • 50 citations

Preclinical toxicology studies with tobramycin

1973 • 49 citations

Structure of hygromycin B, an antibiotic from Streptomyces hygroscopicus; The use of CMR. spectra in structure determination, I

1970 • 49 citations

Butirosin, a New Aminoglycosidic Antibiotic Complex: Bacterial Origin and Some Microbiological Studies

1972 • 48 citations

KANAMYCIN. V. THE STRUCTURE OF KANOSAMINE

1958 • 47 citations

A New Challenge in the Treatment of Thermal Injury

1973 • 47 citations

Bacterial Resistance to Aminoglycoside Antibiotics

1971 • 46 citations

Determination of streptomycin sensitivity by a subunit of the 30 s ribosome of Escherichia coli

1966 • 46 citations

Toxic Effect of Streptomycin upon Balance and Hearing

1957 • 46 citations

STUDIES ON NEW ANTIBIOTIC LIVIDOMYCINS. III

1971 • 46 citations

ISOLATION AND PURIFICATION OF STREPTOMYCIN

1945 • 45 citations

Antibiotic and Chemotherapy.

1968 • 45 citations

STREPTOMYCIN RESISTANCE OF GONOCOCCI AND MENINGOCOCCI

1946 • 45 citations

NEBRAMYCIN: SEPARATION OF THE COMPLEX AND IDENTIFICATION OF FACTORS 4, 5, AND 5''

1973 • 44 citations

PAROMOMYCIN. IV. STRUCTURAL STUDIES

1959 • 43 citations

Chemistry of the Neomycins. X.¹ Neomycins B and C

1962 • 42 citations

Inactivation and Phosphorylation of Kanamycin by Drug-resistant Staphylococcus aureus

1968 • 41 citations

Recent Developments in the Chemistry of Gentamicin

1969 • 39 citations

SYNTHESIS OF 3''-DEOXYKANAMYCIN B

1973 • 39 citations

SYNTHESES OF (S)-4-AMINO-2-HYDROXYBUTYRYL DERIVATIVES OF 3'', 4''-DIDEOXYKANAMYCIN B AND THEIR ANTIBACTERIAL ACTIVITIES

1973 • 38 citations

MICROBIAL SEMI-SYNTHESIS OF AMINOGLYCOSIDIC ANTIBIOTICS BY MUTANTS OF S. RIBOSIDIFICUS AND S. KANAMYCETICUS

1973 • 38 citations

13C-NMR STUDIES ON RIBOSTAMYCIN AND ITS RELATED COMPOUNDS

1973 • 38 citations

STUDIES ON ANTIBIOTIC SF-733, A NEW ANTIBIOTIC. I

1970 • 37 citations

Structure of sisomicin, a novel unsaturated aminoglycoside antibiotic from Micromonospora inyoensis

1971 • 37 citations

Two Enzymes Which Phosphorylate Neomycin and Kanamycin in Escherichia coli Strains Carrying R Factors

1973 • 37 citations

Inactivation of Kanamycin, Neomycin, and Streptomycin by Enzymes Obtained in Cells of Pseudomonas aeruginosa

1968 • 37 citations

PHOSPHORYLATION AND INACTIVATION OF KANAMYGIN BY PSEUDOMONAS AERUGINOSA

1968 • 36 citations

The neomycins and related antibiotics

1964 • 36 citations

SYNTHESES OF 6''-N-METHYL-KANAMYGIN AND 3'', 4''-DIDEOXY-6''-N-METHYLKANAMYCIN B ACTIVE AGAINST RESISTANT STRAINS HAVING 6''-N-ACETYLATING ENZYMES

1972 • 36 citations

Chemical Determination of Component Ratio and Potency of Gentamicin Complex

1973 • 35 citations

Aspects of the Chronic Toxicity of Gentamicin Sulfate in Cats

1971 • 35 citations

Studies of Aminosugars. XXIII. The Total Synthesis of Kanamycin B

1969 • 34 citations

The Chemistry of Bluensomycin. II. the Structure of Bluensomycin

1963 • 34 citations

ISOLATION AND CHARACTERIZATION OF LIVIDOMYCIN A INACTIVATED BY PSEUDOMONAS AERUGINOSA AND ESCHERICHIA COLI CARRYING R FACTOR

1972 • 33 citations

SYNTHESIS OF 3'', 4''-DIDEOXYNEAMINE ACTIVE AGAINST KANAMYCIN-RESISTANT E. COLI AND P. AERUGINOSA

1971 • 33 citations

STUDIES ON NEW ANTIBIOTIC LIVIDOMYCINS

1971 • 31 citations

Studies of Aminosugars. XXI. The Total Synthesis of Kanamycin C

1969 • 31 citations

Streptomycin sensitivity and the structural components of the 30 s ribosomes of Escherichia coli

1966 • 31 citations

NEOMYGINS D, E AND F: IDENTITY WITH PAROMAMINE, PAROMOMYGIN I AND PAROMOMYGIN II

1970 • 31 citations

Ototoxic Side Effects Following Treatment with Streptomycin, Dihydrostreptomycin, and Kanamycin

1964 • 31 citations

The Synthesis of Kanamycin Analogs I. α-<scp>D</scp>-Glucopyranosyl Derivatives of Deoxystreptamine

1973 • 29 citations

Effect of Streptomycin on Vestibular Function

1951 • 29 citations

THE STRUCTURE DETERMINATION OF AN ENZYMATIC INACTIVATION PRODUCT OF 3'', 4''-DIDEOXYKANAMYCIN B

1971 • 28 citations

Streptomyces Antibiotics. XVIII. Structure of Streptomycin

1948 • 28 citations

SYNTHESIS OF BUTIROSIN B

1972 • 27 citations

STUDIES ON NEW ANTIBIOTIC LIVIDOMYCINS. IV

1971 • 27 citations

ISOLATION AND GROSS STRUCTURE OF A NEW ANTIBIOTIC SS-56 C AND RELATED COMPOUNDS

1973 • 27 citations

Strains ofStreptomyces tenebrarius and biosynthesis of nebramycin

1971 • 26 citations

Aminoglycoside antibiotics. II. Configurational and positional isomers of BB-K8.

1973 • 26 citations

Studies on new antibiotic lividomycins. II. Isolation and characterization of lividomycins A, B and other aminoglycosidic antibiotics produced by Streptomyces lividus.

1971 • 26 citations

Mass spectral studies on aminocyclitol antibiotics

1971 • 26 citations

STREPTOMYCES ANTIBIOTICS. XIV. THE POSITION OF THE LINKAGE OF STREPTOBIOSAMINE TO STREPTIDINE IN STREPTOMYCIN

1947 • 26 citations

Proteus Infections in a General Hospital. I. Biochemical Characteristics and Antibiotic Susceptibility of the Organisms

1971 • 26 citations

Inactivation and Phosphorylation of Kanamycin by Drug-resistant Staphylococcus aureus

1968 • 25 citations

Studies on Aminosugars. XXIX. The Synthesis of 3′-O-Methylkanamycin

1972 • 25 citations

Butirosin, a New Aminoglycosidic Antibiotic Complex: Antibacterial Activity In Vitro and in Mice

1972 • 25 citations

ANTIBIOTIC 6640. II

1970 • 24 citations

BIOCHEMICAL STUDIES ON GENTAMICIN RESISTANCE

1970 • 24 citations

CHEMICAL CONVERSION OF LIVIDOMYCIN A INTO LIVIDOMYCIN B

1972 • 24 citations

KANAMYCIN. III. KANAMYCIN B

1958 • 24 citations

Chemistry of the gentamycins. I. Characterization and gross structure of gentamycin A

1967 • 24 citations

GENTAMICIN ACETYLTRANSFERASE IN ESCHERICHIA COLI CARRYING R FACTOR

1973 • 24 citations

AMINOGLYCOSIDE ANTIBIOTICS. IV

1973 • 24 citations

Inhibition of polypeptide synthesis by kasugamycin, an aminoglycosidic antibiotic.

1966 • 23 citations

Development of Streptomycin Resistance of Gram-Negative Bacilli In vitro and During Treatment.

1946 • 23 citations

SYNTHESIS OF PAROMAMINE

1972 • 22 citations

THE STRUCTURE OF NEAMINE

1961 • 22 citations

LOCALIZATION OF SENSITIVITY TO KANAMYCIN AND STREPTOMYCIN IN 30S RIBOSOMAL PROTEINS OF ESCHERICHIA COLI

1969 • 22 citations

AMINOGLYCOSIDE ANTIBIOTICS. III

1973 • 22 citations

SYNTHESIS OF LIVIDOMYCIN A 5''''-PHOSPHATE, AN ENZYMATICALLY INACTIVATED LIVIDOMYCIN A

1972 • 22 citations

AMINOGLYCOSIDE ANTIBIOTICS. II.

1973 • 21 citations

KANAMYCIN 6''-ACETATE AND RIBOSTAMYCIN 6''-ACETATE, ENZYMATICALLY INACTIVATED PRODUCTS BY PSEUDOMONAS AERUGINOSA

1972 • 21 citations

Purification by affinity chromatography of an enzyme involved in gentamicin inactivation

1973 • 21 citations

PLASMID-MEDIATED GENTAMIGIN RESISTANCE NOT ASSOCIATED WITH KANAMYCIN RESISTANCE IN ENTEROBACTERIACEAE

1972 • 21 citations

The preparation and biological activity of novel amino acid analogs of butirosin

1973 • 21 citations

Studies on new antibiotic lividomycins. I. Taxonomic studies on the lividomycin-producing strain Streptomyces lividus nov. sp.

1971 • 20 citations

Studies of Aminosugars. XXII. The Total Synthesis of Kanamycin A

1969 • 20 citations

SYNTHESES OF 3'', 4''-DIDEOXY AND 3'', 4'', 5''''-TRIDEOXYRIBOSTAMYGIN ACTIVE AGAINST KANAMYCIN-RESISTANT E. COLI AND P. AERUGINOSA

1972 • 19 citations

NEOMYCIN PRODUCTION BY MICROMONOSPORA SPECIES 69-683

1973 • 19 citations

Activity of Lividomycin Against Pseudomonas aeruginosa: Its Inactivation by Phosphorylation Induced by Resistant Strains

1972 • 18 citations

INAGTIVATION OF 3'', 4''-DIDEOXY-KANAMYGIN B BY AN ENZYME SOLUTION OF RESISTANT E. COLI AND ISOLATION OF 3'', 4''-DIDEOXYKANAMYCIN B 2''''-GUANYLATE AND 2''''-INOSINATE

1972 • 18 citations

Effect of Streptomycin on the Incorporation of Tyrosine labelled with Carbon-14 into Protein of Mycobacterium Cell Fractions in vivo

1960 • 17 citations

STRUCTURAL FEATURE OF ANTIBIOTIC A-396-I

1970 • 17 citations

SYNTHESIS OF 1-N-((s)-4-AMINO-2-HYDROXYBUTYRYL)-3'', 4''-DIDEOXYNEAMINE

1973 • 17 citations

SYNTHESIS OF 3''-DEOXYRIBOSTAMYCIN

1973 • 17 citations

Über die Hemmung der neuromuskulären Übertragung durch einige Antibiotika

1960 • 17 citations

LOCALIZATION OF KANAMYGIN SENSITIVITY IN THE 23S CORE OF 30S RIBOSOMES OF E. COLI

1968 • 16 citations

STUDIES ON NEW ANTIBIOTIC LIVIDOMYCINS

1971 • 16 citations

SYNTHESIS OF 3'', 4''-DIDEOXYBUTIROSIN B

1973 • 16 citations

EXTRACTION AND PURIFICATION OF STREPTOMYCIN, WITH A NOTE ON STREPTOTHRICIN

1946 • 16 citations

THE PREPARATION OF GARAMINE, A NOVEL PSEUDODISACCHARIDE FROM SISOMICIN

1973 • 16 citations

PREPARATION OF TWO NEW AMINOGLYCOSIDE ANTIBIOTICS

1970 • 15 citations

Synthesis of 3-amino-2,3-dideoxy-α-D-arabino-hexopyranosyl gentamine C1

1973 • 15 citations

STUDIES ON NEW ANTIBIOTIC LIVIDOMYCINS. V

1972 • 14 citations

SYNTHESES OF ISOSERYL DERIVATIVES OF KANAMYCINS AND THEIR ANTIBACTERIAL ACTIVITIES

1974 • 13 citations

SYNTHESIS OF 5''''-DEOXYLIVIDOMYCIN B

1972 • 13 citations

Aminoglycoside antibiotics: chemical transformation of paromamine into 3′-epiparomamine

1973 • 13 citations

5"-AMINO-5"-DEOXYBUTIROSIN, A NEW SEMI-SYNTHETIC AMINOGLYCOSIDE ANTIBIOTIC

1973 • 13 citations

TRANSGLYGOSYLATION OF NEAMINE

1972 • 12 citations

BYCONVERSION OF RIBOSTAMYCIN (SF-733)

1973 • 12 citations

SYNTHESIS OF TETRA-N-PHENYLALKYLKANAMYCINS AND THEIR ANTIMICROBIAL ACTIVITIES

1968 • 12 citations

Evaluation of Non-lactose-fermenting Members of the Klebsiella–Enterobacter–Serratia Division: II. Antibiotic Susceptibility

1970 • 12 citations

Gentamicin antibiotics. 4. Some condensation products of gentamicin C2 with aromatic and aliphatic aldehydes

1971 • 12 citations

Structure-activity relationships among the aminoglycoside antibiotics: comparison of the neomycins and hybrimycins

1970 • 11 citations

STREPTOMYCIN: CORRELATION BETWEEN IN VIVO AND IN VITRO ACTIVITY OF TEN REPRESENTATIVE DERIVATIVES

1972 • 11 citations

SYNTHESES OF 3''- AND 4''-O-METHYLENEAMINE

1972 • 10 citations

Streptomycin Tolerance of Saprophytic and Pathogenic Fungi

1947 • 10 citations

Contribution of the Cationic Groups of Dihydrostreptomycin to Biological Activity

1965 • 10 citations

THE SYNTHESIS OF KANAMYCIN-6"-UR0NIC ACID, ITS ESTER AND AMIDE

1970 • 10 citations

SYNTHESES OF 5''''-DEOXYLIVIDO-MYCIN A AND ITS AMINO DERIVATIVE

1972 • 10 citations

SYNTHESIS OF 1-N-((s)-4-AMINO-2-HYDROXYBUTYRYL) LIVIDOMYCIN A

1973 • 9 citations

ON THE STEREOCHEMISTRY OF THE PIMARIC ACIDS

1958 • 9 citations

THE SYNTHESIS OF 4"-DEOXYGENTAMICIN C1

1973 • 8 citations

SYNTHESES OF 6''-AMINO-6''-DEOXYLIVI-DOMYCIN B AND 6''-DEOXY-6''-METHYLAMINO- AND 6''-DEOXY-6''-(2-HYDROXYETHYLAMINO)- LIVIDOMYCIN B

1973 • 7 citations

THE STRUCTURE OF MANNOSYLPAROMOMYGIN (No. 2230-C)

1972 • 7 citations

Antibacterial Activity of Lividomycin Toward R Factor-Resistant Strains of Escherichia coli

1972 • 7 citations

The Prolongation of the Viability of Cultures of E. histolytica by the Addition of Streptomycin

1947 • 7 citations

THE TRANSGLYCOSYLATION OF KANAMYGIN A

1972 • 5 citations

Chemical Modification of Kanamycin. II. Syntheses of 3'-Amino-3'-deoxykanamycin and 3'-Amino-3'-deoxy-2'-mannokanamycin

1968 • 5 citations

CHEMISTRY AND BIOCHEMISTRY OF THE NEOMYCINS. XVI

1973 • 4 citations

RECENT LABORATORY STUDIES WITH GENTAMICIN WITH REFERENCE TO STRUCTURE AND RESISTANCE

1970 • 4 citations