APC and K-ras gene mutation in aberrant crypt foci of human colon

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: Preliminary findings

1987 • 1,036 citations

Aberrant crypts: putative preneoplastic foci in human colonic mucosa.

1991 • 448 citations

Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons.

1994 • 286 citations

p53 in colorectal cancer: clinicopathological correlation and prognostic significance

1991 • 221 citations

Altered expression of β-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis

2000 • 167 citations

Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa

1997 • 132 citations

Aberrant crypt foci in human colons: Distribution and histomorphologic characteristics*1, *2

1998 • 95 citations

Histology of aberrant crypt foci in the human colon

1997 • 82 citations

K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients.

1997 • 79 citations

Infrequent K-ras codon 12 mutation in serrated adenomas of human colorectum

1998 • 75 citations

Promotion of Aberrant Crypt Foci and Cancer in Rat Colon by Thermolyzed Protein

1992 • 72 citations

The I1307K polymorphism of the APC gene in colorectal cancer

1999 • 72 citations

K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients

1997 • 71 citations

Aberrant crypt foci in patients with neoplastic and nonneoplastic colonic disease

1999 • 71 citations

Reduction in formation and growth of 1,2-dimethylhydrazine-induced aberrant crypt foci in rat colon by docosahexaenoic acid.

1993 • 69 citations

Infrequent somatic mutation of the adenomatous polyposis coli gene in aberrant crypt foci of human colon tissue

1998 • 68 citations

Detection of somatic DNA alterations in azoxymethane-induced F344 rat colon tumors by random amplified polymorphic DNA analysis

2000 • 68 citations

K-ras AND p53 MUTATIONS IN HUMAN COLORECTAL ABERRANT CRYPT FOCI

1996 • 66 citations

Aberrant crypt foci in patients with colorectal cancer

1998 • 63 citations

Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?

1995 • 62 citations

Somatic instability of the APC I1307K allele in colorectal neoplasia.

1998 • 60 citations

Mutations of the Apc gene in experimental colorectal carcinogenesis induced by azoxymethane in F344 rats

1998 • 58 citations

Effect of K-ras mutation on morphogenesis of colorectal adenomas and early cancers: Relationship to distribution of proliferating cells

1996 • 52 citations

APC mutation and the crypt cycle in murine and human intestine.

1997 • 51 citations

Association of APC gene mutations and histological characteristics of colorectal adenomas.

1994 • 49 citations

Natural history of aberrant crypt foci

1996 • 49 citations

K-ras gene mutation is a useful predictor of the survival of early stage colorectal cancers.

1996 • 48 citations

K-ras codon 12 mutation determines the polypoid growth of colorectral cancer.

1998 • 47 citations

K-ras mutations in patients with early colorectal cancers

1997 • 40 citations

Genetic analysis of multiple synchronous lesions of the colon adenoma–carcinoma sequence

2000 • 38 citations

Molecular profiling of sporadic colorectal tumors by microsatellite analysis.

2000 • 24 citations

K-ras mutations in colorectal adenocarcinomas and neighbouring transitional mucosa

1998 • 21 citations

APC mutations in human colorectal adenomas: analysis of the mutation cluster region with temperature gradient gel electrophoresis and clinicopathological features

1998 • 20 citations

Optimizing the APC Gene Mutation Analysis in Archival Colorectal Tumor Tissue

1999 • 19 citations

Inhibition of aberrant crypt foci by chemopreventive agents.

1998 • 18 citations

Ras oncogene activation in benign and malignant colorectal tumours.

1995 • 14 citations

c-Ki-ras mutations in colorectal adenocarcinomas from a country with a rapidly changing colorectal cancer incidence

1999 • 14 citations

Methylation status ofp16gene in colorectal carcinoma and normal colonic mucosa

1999 • 13 citations

Comparison of gene expression between normal colon mucosa and colon carcinoma by means of messenger RNA differential display

1999 • 12 citations

Colonic aberrant crypts may originate from impaired fissioning: Relevance to increased risk of neoplasia*1

1999 • 11 citations

Tumor suppressor genes in molecular medicine

1994 • 11 citations

Differential activation of the c-Ki-ras-2 proto-oncogene in human colorectal carcinoma.

1998 • 6 citations

[Aberrant crypt foci as biomarkers in chemoprevention for colorectal cancer].

1998 • 6 citations

Early molecular biological events of the adenomas from familial adenomatous polyposis:analysis of single crypt microdissection

2000 • 2 citations

[Genome analyses for precancerous lesions in the gastrointestinal tract].

2000 • 2 citations

Clinical significance of immunohistochemical study of p53 protein in colorectal carcinoma

1996 • 2 citations

Expression of P53 oncoprotein in benign and malignant lesions of large bowel

1996 • 2 citations

Relationship between loss of heterozygosity of microsatellite on DCC gene and prognosis of colorectal adenocarcinoma

1997 • 1 citations

Relationship between loss of heterozygosity of deleted in colorectal carcinoma gene microsatellites and prognosis of colorectal adenocarcinoma

2011 • 1 citations