Potential of immobilized artificial membranes for predicting drug penetration across the blood-brain barrier.

Substituent constants for correlation analysis in chemistry and biology

1979 • 2,909 citations

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

1980 • 799 citations

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

1988 • 514 citations

Transporting therapeutics across the blood-brain barrier

1996 • 429 citations

Transport of Steroid Hormones through the Rat Blood-Brain Barrier

1979 • 422 citations

Transport of small molecules through the blood-brain barrier: biology and methodology

1995 • 265 citations

A method to determine the ability of drugs to diffuse through the blood-brain barrier.

1994 • 195 citations

Hydrophobicity estimations by reversed-phase liquid chromatography

1993 • 194 citations

The blood‐brain barrier

1993 • 191 citations

Membrane Partition Coefficients Chromatographically Measured Using Immobilized Artificial Membrane Surfaces

1995 • 177 citations

Immobilized Artificial Membranes — screens for drug membrane interactions

1997 • 161 citations

Determination of solute lipophilicity, as log P(octanol) and log P(alkane) using poly(styrene–divinylbenzene) and immobilised artificial membrane stationary phases in reversed-phase high-performance liquid chromatography

1997 • 161 citations

The use of the intestinal epithelial cell culture model, Caco-2, in pharmaceutical development

1996 • 138 citations

Comparison of lipid-mediated blood-brain-barrier penetrability in neonates and adults

1982 • 117 citations

Chromatographic hydrophobicity parameter determined on an immobilized artificial membrane column: relationships to standard measures of hydrophobicity and bioactivity

1994 • 72 citations

Predicting blood-brain transport of drugs: a computational approach.

1996 • 65 citations

Methods of Study

1992 • 49 citations

The pH-dependence in the partitioning behaviour of (RS)-[3H]propranolol between MDCK cell lipid vesicles and buffer.

1996 • 37 citations

Fatty acid composition of brain capillary endothelial cells: effect of the coculture with astrocytes

1995 • 35 citations

Partitioning of teniposide into membranes and the role of lipid composition

1990 • 27 citations

Immobilized Artificial Membrane Chromatography: Surface Chemistry and Applications

1991 • 24 citations

Immobilized Artificial Membrane Chromatography Prediction of Drug Transport across Biological Barriers

1993 • 11 citations