Relationship between antioxidants, lipid peroxidation and aging

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Free Radicals in Biology

1976 • 1,879 citations

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

1990 • 1,100 citations

Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects

1990 • 581 citations

A case‐control study of gastric cancer and diet in Italy

1989 • 547 citations

Mechanisms and Consequences of Lipid Peroxidation in Biological Systems

1985 • 520 citations

Free Radical Theory of Aging: Effect of Free Radical Reaction Inhibitors on the Mortality Rate of Male LAF1 Mice

1968 • 339 citations

Influences of Dietary Restriction and Age on Liver Enzyme Activities and Lipid Peroxidation in Mice

1987 • 280 citations

Antioxidants, Aging, and Longevity

1984 • 279 citations

The antioxidant hypothesis of cardiovascular disease: epidemiology and mechanisms

1990 • 276 citations

Glutathione contents of tissues in the aging mouse

1980 • 268 citations

Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat

1987 • 241 citations

A case‐control study of gastric cancer and diet in Italy: II. Association with nutrients

1990 • 240 citations

Effect of Dietary Restriction on the Age-Dependent Changes in the Expression of Antioxidant Enzymes in Rat Liver

1990 • 206 citations

Prediagnostic serum levels of carotenoids and vitamin E as related to subsequent cancer in Washington County, Maryland

1991 • 204 citations

Superoxide dismutase, glutathione peroxidase, catalase, and lipid peroxidation in the major organs of the aging rats

1989 • 204 citations

Free Radicals in Molecular Biology, Aging, and Disease

1985 • 203 citations

An integrated theory of aging as the result of mitochondrial-DNA mutation in differentiated cells

1991 • 198 citations

Age-related changes in antioxidant enzymes and prooxidant generation in tissues of the rat with special reference to parameters in two insect species

1990 • 193 citations

Effect of age on the expression of antioxidant enzymes in male Fischer F344 rats

1990 • 189 citations

Effect of age on superoxide dismutase, catalase, glutathione reductase, inorganic peroxides, TBA-reactive material, GSH/GSSG, NADPH/NADP+ and NADH/NAD+ in Drosophila melanogaster

1990 • 180 citations

Changes in the expression of superoxide dismutase and catalase as a function of age and dietary restriction

1989 • 178 citations

Hydrogen peroxide production by liver mitochondria in different species

1990 • 173 citations

Regional Distributions of Thiobarbituric Acid‐Reactive Products, Activities of Enzymes Regulating the Metabolism of Oxygen Free Radicals, and Some of the Related Enzymes in Adult and Aged Rat Brains

1986 • 163 citations

Superoxide anion radical production in different animal species

1989 • 162 citations

Comparison of cytoplasmic superoxide dismutase in liver, heart and brain of aging rats and mice

1976 • 161 citations

Effect of chronic food restriction in aging rats II. Liver cytosolic antioxidants and related enzymes

1989 • 127 citations

Superoxide Dismutase in the Rat and Mouse as a Function of Age and Longevity

1976 • 125 citations

Anti-oxidant defences and peroxidation in liver and brain of aged rats

1990 • 124 citations

Sex-dependent differences in the effects of aging on antioxidant defense mechanisms of rat liver

1991 • 122 citations

Antioxidant Enzymes and Related Trace Elements in Aging Brain Capillaries and Choroid Plexus

1989 • 118 citations

Expression of supreoxide dismutase and catalase in rat brain as a function of age

1991 • 111 citations

Effect of Antioxidants on Life-Span of C57BL Mice

1971 • 109 citations

Differential Changes in Superoxide Dismutase Activity in Brain and Liver of Old Rats and Mice

1983 • 105 citations

Effect of aging on aqueous-phase antioxidants in tissues of male Fischer rats

1988 • 103 citations

Effect of catalase inactivation on levels of inorganic peroxides, superoxide dismutase, glutathione, oxygen consumption and life span in adult houseflies (Musca domestica)

1983 • 88 citations

Vitamin E, Immune Response, and Disease Resistance^a

1989 • 78 citations

Effect of age on oxygen consumption, superoxide dismutase, catalase, glutathione, inorganic peroxides and chloroform-soluble antioxidants in the adult male housefly, Musca domestica

1984 • 68 citations

Age‐Dependent Variations in Peroxide‐Utilizing Enzymes from Rat Brain Mitochondria and Cytoplasm

1984 • 65 citations

Effect of age and ambient temperature on n-pentane production in adult housefly, Musca domestica

1985 • 62 citations

Effects of diethyldithiocarbamate on life span, metabolic rate, superoxide dismutase, catalase, inorganic peroxides and glutathione in the adult male housefly, Musca domestica

1984 • 58 citations

Mitochondrial function and superoxide generation from submitochondrial particles of aged rat hearts

1990 • 57 citations

Physical-Chemical and Biochemical Differences in Liver Plasma Membranes in Aging F-344 Rats

1985 • 56 citations

Effect of Age on Vitamin E Concentrations in Various Regions of the Brain and a Few Selected Peripheral Tissues of the Rat, and on the Uptake of Radioactive Vitamin E by Various Regions of Rat Brain

1984 • 53 citations

Aging influence on delta-6-desaturase activity and fatty acid composition of rat liver microsomes.

1988 • 52 citations

Aging and lung antioxidant enzymes, glutathione, and the lipid peroxidation in the rat☆

1991 • 51 citations

Changes induced by aging and drug treatment on cerebral enzymatic antioxidant system

1988 • 46 citations

Influence of aging and drug treatment on the cerebral glutathione system

1988 • 43 citations

Copper-Zinc and Manganese Superoxide Dismutase Activities in Cardiac and Skeletal Muscles during Aging in Male Rats

1984 • 42 citations

Superoxide dismutase and cytochrome oxidase activities in light and heavy synaptic mitochondria from rat cerebral cortex during aging

1989 • 40 citations

Differences in the influence of diet on Hepatic Glutathione S-transferase activity and glutathione content between young and old C57 black female mice

1989 • 39 citations

Persistent protein damage despite reduced oxygen radical formation in the aging rat brain

1991 • 39 citations

Effect of Vitamin E Supplementation on Immune Responsiveness of the Aged^a

1989 • 38 citations

Influence of oxidative stress on the age‐linked alterations of the cerebral glutathione system

1990 • 37 citations

Recent progress in testing the longevity determinant and dysdifferentiation hypotheses of aging

1991 • 36 citations

Age-related changes in lipid peroxidation and protective enzymes in the central nervous system.

1989 • 33 citations

Cerebral Enzyme Antioxidant System. Influence of Aging and Phosphatidylcholine

1989 • 30 citations

Senescence‐associated decrease of NADPH‐induced lipid peroxidation in rat liver microsomes

1986 • 30 citations

<b>SENSITIVE IMMUNOASSAY OF RAT Cu/Zn SUPEROXIDE DISMUTASE: CONCENTRATIONS IN THE BRAIN, LIVER, AND KIDNEY ARE NOT AFFECTED BY </b><b>AGING </b>

1990 • 25 citations

Effect of natural ageing and antioxidant inhibition on liver antioxidant enzymes, glutathione system, peroxidation, and oxygen consumption inRana perezi

1991 • 22 citations

Lung antioxidant enzymes, peroxidation, glutathione system and oxygen consumption in catalase inactivated young and old Rana perezi frogs

1990 • 20 citations

Changes in ascorbate-induced lipid peroxidation of hepatic rough and smooth microsomes during postnatal development and ageing of rats

1986 • 18 citations

Changes on cerebral antioxidant enzymes, peroxidation, and the glutathione system of frogs after aging and catalase inhibition

1990 • 14 citations

Liver and Brain

1963 • 10 citations