Exo-site affinity labeling of human thrombins. Similar labeling on the A chain and B chain/fragments of clotting alpha- and nonclotting gamma/beta-thrombins.

The Reliability of Molecular Weight Determinations by Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis

1969 • 20,498 citations

Proteases and biological control

1976 • 1,380 citations

Sulfonyl Fluorides as Inhibitors of Esterases. I. Rates of Reaction with Acetylcholinesterase, α-Chymotrypsin, and Trypsin

1963 • 646 citations

TRITIUM-LABELING BY EXPOSURE OF ORGANIC COMPOUNDS TO TRITIUM GAS¹

1957 • 633 citations

Human thrombins. Production, evaluation, and properties of alpha-thrombin.

1977 • 587 citations

Comparison of the esterase activities of trypsin, plasmin, and thrombin on guanidinobenzoate esters. Titration of the enzymes

1969 • 433 citations

Design of Active-Site-Directed Irreversible Enzyme Inhibitors.

1967 • 387 citations

Rapid method for the purification of bovine thrombin and the inhibition of the purified enzyme with phenylmethylsulfonyl fluoride

1971 • 281 citations

Homologies in serine proteinases

1970 • 239 citations

Covalent Labeling of Active Sites

1967 • 225 citations

Affinity Labeling—a General Method for Labeling the Active Sites of Antibody and Enzyme Molecules^*

1962 • 217 citations

Equilibrium binding of thrombin to platelets

1976 • 154 citations

A biologist's physical chemistry

1974 • 139 citations

Comparative Studies on the Inhibition of Trypsin, Plasmin, and Thrombin by Derivatives of Benzylamine and Benzamidine

1968 • 133 citations

Human prothrombin activation

1975 • 131 citations

Polyethylene glycol 6,000 enhancement of the clotting of fibrinogen solutions in visual and mechanical assays

1974 • 81 citations

Thrombin adsorption to surfaces and prevention with polyethylene glycol 6,000

1976 • 74 citations

The specific inactivation of trypsin by ethyl p-guanidinobenzoate.

1967 • 60 citations

Human thrombin: Partial primary structure

1977 • 57 citations

Nature of the active site of a subunit of the first component of human complement

1969 • 55 citations

Mechanism of action of thrombin on fibrinogen

1974 • 55 citations

Multiple Active Forms of Thrombin

1973 • 53 citations

The Specific Inactivation of Trypsin by Ethyl p-Guanidinobenzoate

1967 • 53 citations

Spin-labeled Sulfonyl Fluorides as Active Site Probes of Protease Structure

1974 • 41 citations

Specificity of thrombin

1973 • 35 citations

Sepharose-bound trypsin and activated sepharose-bound trypsinogen

1974 • 34 citations

Mechanism of action of thrombin on fibrinogen

1974 • 30 citations

Amino acid sequence of human thrombin A chain

1974 • 27 citations

Structural aspects of thrombin specificity

1975 • 21 citations

An X-ray Crystallographic Study of Thrombin

1974 • 20 citations

Irreversible enzyme inhibitors. 186. Irreversible inhibitors of the C'la component of complement derived from m-(phenoxypropoxy)benzamidine by bridging to a terminal sulfonyl fluoride

1971 • 17 citations

Irreversible enzyme inhibitors. CLXXII. Proteolytic enzymes. XVI. Covalent bonding of the sulfonyl fluoride group to serine outside the active-site of .alpha.-chymotrypsin by exo-type active-site directed irreversible inhibitors

1970 • 16 citations

The Enzymic Properties of Thrombin and Factor Xa

1973 • 16 citations