General Aspects of Endocrinology

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

FRACTIONATION AND CHARACTERIZATION OF A CYCLIC ADENINE RIBONUCLEOTIDE FORMED BY TISSUE PARTICLES

1958 • 1,055 citations

A two-step mechanism for the interaction of estradiol with rat uterus.

1968 • 1,013 citations

Cyclic AMP

1968 • 954 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 811 citations

Mechanism of Action of the Female Sex Hormones

1972 • 763 citations

Insulin Biosynthesis: Evidence for a Precursor

1967 • 699 citations

ADENYL CYCLASE AS AN ADRENERGIC RECEPTOR*

1967 • 682 citations

A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization.

1966 • 680 citations

Adenosine 3‘, 5‘-Monophosphate in Biological Materials

1965 • 597 citations

The role of cyclic-3',5'-AMP in responses to catecholamines and other hormones.

1966 • 573 citations

The concept of carrier transport and its corollaries in pharmacology.

1961 • 541 citations

New Hypothesis of Insulin Secretion

1968 • 539 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 487 citations

Induction of tyrosine alpha-ketoglutarate transaminase by steroid hormones in a newly established tissue culture cell line.

1966 • 484 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 473 citations

Insulin-Receptor Interactions in Adipose Tissue Cells: Direct Measurement and Properties

1971 • 443 citations

Induktion von puff-veränderungen in den speicheldrüsenchromosomen von Chironomus t̆entans durch Ecdyson

1960 • 434 citations

Insulin Interactions with Liver Plasma Membranes

1972 • 396 citations

Adenosine 3‘,5‘-Monophosphate as the Intracellular Mediator of the Action of Adrenocorticotropic Hormone on the Adrenal Cortex

1967 • 395 citations

INTERACTION OF INSULIN WITH THE CELL MEMBRANE: THE PRIMARY ACTION OF INSULIN

1969 • 381 citations

Proteins Associated with the Thyroid Hormones

1960 • 358 citations

Adenyl Cyclase in Fat Cells

1969 • 352 citations

Studies on the Mechanism of Steroid Hormone Regulation of Synthesis of Specific Proteins

1969 • 352 citations

The Application of Control Theory to Physiological Systems.

1966 • 340 citations

Mechanisms Regulating the Menstrual Cycle in Women

1970 • 339 citations

A Possible Role for the Adenylcyclase System in Insulin Secretion*

1967 • 320 citations

Porcine Proinsulin: Characterization and Amino Acid Sequence

1968 • 318 citations

Biological control systems analysis

1966 • 314 citations

ACTH Receptors in the Adrenal: Specific Binding of ACTH- ¹²⁵ I and Its Relation to Adenyl Cyclase

1970 • 303 citations

Properties of the Insulin Receptor Isolated from Liver and Fat Cell Membranes

1972 • 299 citations

Catalysis of the Phosphorylase Kinase Activation Reaction

1971 • 294 citations

Mechanism of action of aldosterone

1966 • 282 citations

ON THE MECHANISM OF ACTION OF ALDOSTERONE ON SODIUM TRANSPORT: THE ROLE OF RNA SYNTHESIS

1964 • 279 citations

Role of Plasma Proteins in the Binding, Distribution and Metabolism of the Thyroid Hormones

1968 • 266 citations

ON THE MECHANISM OF ACTION OF ALDOSTERONE ON SODIUM TRANSPORT: THE ROLE OF PROTEIN SYNTHESIS

1963 • 265 citations

BINDING OF THYROXINE BY SERUM PROTEINS EVALUATED BY EQUILIBRIUM DIALYSIS AND ELECTROPHORETIC TECHNIQUES. ALTERATIONS IN NON-THYROIDAL ILLNESS*

1963 • 261 citations

Role of DNA and Specific Cytoplasmic Receptors in Glucocorticoid Action

1972 • 248 citations

Modulation of Adenylate Cyclase Activity in Liver and Fat Cell Membranes by Insulin

1972 • 243 citations

The action of insulin on the transport of glucose through the cell membrane

1959 • 237 citations

Biological control systems analysis

1967 • 236 citations

Adenyl Cyclase in Fat Cells

1970 • 235 citations

Properties of the Insulin Receptor of Isolated Fat Cell Membranes

1971 • 227 citations

Estrogen Action in Vitro

1972 • 221 citations

Glucose Uptake by Incubated Rat Epididymal Adipose Tissue

1965 • 204 citations

DYNAMIC ASYMMETRIES IN THE CORTICOSTEROID FEEDBACK PATH AND DISTRIBUTION METABOLISM‐BINDING ELEMENTS OF THE ADRENOCORTICAL SYSTEM*

1969 • 192 citations

Biochemical Actions of Thyroid Hormones

1962 • 188 citations

Unmasking of Insulin Receptors in Fat Cells and Fat Cell Membranes

1971 • 184 citations

Hormonal Regulation of Growth and Protein Synthesis

1968 • 183 citations

Biochemical Differentiation during Amphibian Metamorphosis

1970 • 180 citations

Myocardial adenyl cyclase: activation by thyroid hormones and evidence for two adenyl cyclase systems

1969 • 165 citations

The Hormonal Control of Lactose Synthetase in the Developing Mouse Mammary Gland

1968 • 159 citations

Progestogen-induced luteinizing and follicle-stimulating hormone surge in postmenopausal women: a simulated ovulatory peak.

1968 • 153 citations

Role of the Receptor in the Mechanism of Action of Adenosine 3′:5′-Cyclic Monophosphate

1971 • 149 citations

Insulin-like Activity of Dilute Human Serum Assayed by an Isolated Adipose Cell Method

1965 • 145 citations

Some Aspects of Steroid Hormone Action

1963 • 145 citations

Regulation of Phosphoenolpyruvate Carboxykinase and Tyrosine Transaminase in Hepatoma Cell Cultures

1971 • 143 citations

Synthesis of Ribonucleic Acid during Early Estrogen Action

1968 • 138 citations

The Reaction of Glucagon with Its Receptor: Evidence for Discrete Regions of Activity and Binding in the Glucagon Molecule

1971 • 131 citations

UNIDIRECTIONAL RATE SENSITIVITY: A BIOCYBERNETIC* LAW OF REFLEX AND HUMORAL SYSTEMS AS PHYSIOLOGIC CHANNELS OF CONTROL AND COMMUNICATION†

1961 • 128 citations

The Pancreatic Beta Cell

1967 • 126 citations

Chemical and biological factors in the activity of adrenocortical steroids.

1962 • 115 citations

A RELATIONSHIP BETWEEN THE BLOOD SUGAR LEVEL AND THE RATE OF SUGAR UTILIZATION, AFFECTING THE THEORIES OF DIABETES

1937 • 112 citations

Effects of insulin treatment on muscle 3′,5′-cyclic adenylate levels in vivo and in vitro

1967 • 110 citations

Subcellular Distribution of³H-estradiol in Rat Uterus by Quantitative Autoradiography—A Comparison Between³H-estradiol and³H-norethynodrel

1968 • 109 citations

Effects of thyroid hormones on adenyl cyclase in adipose tissue and on free fatty acid mobilization.

1968 • 109 citations

Regulation of the Pituitary-Thyroid Axis in Man: Relationship of TSH Concentration to Concentration of Free and Total Thyroxine in Plasma

1967 • 108 citations

Influence of Cortisol on the Utilization of Precursors of Nucleic Acids and Protein by Lymphoid Cells in Vitro

1968 • 106 citations

Biochemische Wirkungsweise der Hormone¹

1961 • 105 citations

The Uptake and Inactivation of Native Insulin by Isolated Fat Cells

1968 • 99 citations

The Effect of Thyroxine on Isolated Dehydrogenases

1962 • 96 citations

Stimulation of Ribonucleic Acid Synthesis by Steroid Hormones

1965 • 96 citations

Protein-Steroid Interactions and Their Role in the Transport and Metabolism of Steroids

1966 • 94 citations

ENHANCEMENT BY CAFFEINE OF GLUCAGON-INDUCED AND TOLBUTAMIDE-INDUCED INSULIN RELEASE FROM ISOLATED FŒTAL PANCREATIC TISSUE

1967 • 83 citations

SEPARATION OF THE BIOSYNTHESIS OF THE ANTIBIOTIC POLYPEPTIDE TYROCIDINE FROM PROTEIN BIOSYNTHESIS

1963 • 81 citations

Stimulation of Ribonucleic Acid Synthesis by Steroid Hormones

1965 • 80 citations

Mechanisms of stimulation of protein synthesis by thyroid hormones in vivo.

1968 • 79 citations

Adenohypophyseal Secretory Granules

1971 • 74 citations

GROWTH HORMONE CONTROL OF BIOSYNTHESIS OF PROTEIN AND RIBONUCLEIC ACID.

1965 • 71 citations

A theoretical basis of molecular pharmacology. I. Interactions of one or two compounds with one receptor system.

1956 • 71 citations

Insulin regulation of protein synthesis by muscle ribosomes: effect of the hormone on translation of messenger RNA for a regulatory protein.

1966 • 70 citations

Effects of N-Ethyl Maleimide and Insulin upon Adipose Tissue

1963 • 70 citations

Chemistry and structure-activity relations of the antidiuretic hormones

1967 • 69 citations

Isolated adrenal cells: ACTH_11–24, a competitive antagonist of ACTH_1–39 and ACTH_1–10

1971 • 67 citations

Catecholamines

1965 • 66 citations

Posttranscriptional Control of Tyrosine Aminotransferase Synthesis by Insulin

1970 • 64 citations

Role of Cyclic Adenosine 3',5'-Monophosphate in the Induction of Hepatic Enzymes

1971 • 63 citations

Induction of Milk Protein Synthesis by Placental Lactogen and Prolactinin Vitro

1968 • 62 citations

Inheritance of Decreased Thyroxine-Binding by the Thyroxine-Binding Globulin1

1964 • 56 citations

Insulin Dependence of Cells in Primary Culture: Influence on Ribosome Integrity

1968 • 56 citations

Early action of injected L-thyroxine on mitochondrial oxidative phosphorylation.

1967 • 52 citations

THE INTERACTION OF THE THYROID HORMONES WITH THE PROTEINS OF HUMAN PLASMA*

1960 • 51 citations

Effects of a Single Injection of Cortisol on Amino Acid-incorporating Activities of Rat Liver and Thymic Preparations in Vitro

1966 • 49 citations

AN INFLUENCE OF INSULIN ON THE SYNTHESIS OF A RAPIDLY LABELED RNA BY ISOLATED RAT DIAPHRAGM

1963 • 42 citations

Epinephrine: Cascade Reactions and Glycogenolytic Effect

1966 • 42 citations

Alteration of Deoxyribonucleic Acid-dependent Ribonucleic Acid Polymerase Activities in Amphibian Liver Nuclei during Thyroxine-induced Metamorphosis

1972 • 40 citations

The Mechanism of Inhibition of Horse Liver Alcohol Dehydrogenase by Thyroxine and Related Compounds

1968 • 38 citations

RIBONUCLEIC ACID SYNTHESIS AND OESTRADIOL ACTION IN THE UTERUS

1972 • 27 citations

Action of Thyroid-Stimulating Hormone on Ribonucleic Acid Synthesis in Thyroid Slices and in Isolated Thyroid Nuclei

1965 • 25 citations

The Upjohn Lecture of The Endocrine Society1 On the Mechanism of Molecular Interactions in the Control of Cellular Metabolism

1966 • 21 citations

How Repressor Molecules Function

1968 • 16 citations

Insulin structure and function

1966 • 15 citations

Wirkung der Hormone auf den Zellkern

1967 • 14 citations

Hormonhemmer — Untersuchungen mit Testosteron-Antagonisten

1967 • 13 citations

A Continuous System Model of Adrenocortical Function

1968 • 13 citations

INDUCTION OF SPECIFIC TRANSLATABLE MESSENGER RNA'S BY OESTROGEN AND PROGESTERONE

1972 • 10 citations

The Mitochondrion

1967 • 10 citations

Effect of Thyroid-stimulating Hormone on Ribonucleic Acid Synthesis in the Calf Thyroid in Vitro in the Presence of Puromycin

1968 • 8 citations

INVESTIGATIONS OF INTRAUTERINE DEVICES IN MACACA MULATTA MONKEYS

1972 • 8 citations

Regulation of succinate oxidation by endogenous reduced nicotinamide adenine dinucleotides in intact heart mitochondria

1971 • 7 citations

Possible role or significance of protein-steroid binding in plasma.

1968 • 6 citations

Aspects of Glucagon-Induced Lipolysis in Adipose Tissue

1968 • 1 citations

Operational definition of the hormone.

1971 • 1 citations

Definition of Thixotropy

1969 • 1 citations