Encapsulation of Hemoglobin in Liposomes

The hydrophobic effect

1980 • 1,922 citations

Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.

1988 • 1,103 citations

Semipermeable Microcapsules

1964 • 983 citations

Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation times

1991 • 539 citations

The effect of particle size and charge on the clearance rates of liposomes and liposome encapsulated drugs

1975 • 516 citations

Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM1-containing liposomes

1992 • 453 citations

Serum opsonins and liposomes: their interaction and opsonophagocytosis.

1992 • 297 citations

Thermomechanical and transition properties of dimyristoylphosphatidylcholine/cholesterol bilayers

1988 • 274 citations

Critical Reviews in Therapeutic Drug Carrier Systems

2020 • 235 citations

Stability of liposomes invivo and invitro is promoted by their cholesterol content and the presence of blood cells

1979 • 228 citations

Synthetic erythrocytes from lipid encapsulated hemoglobin.

1980 • 190 citations

Effects of cholesterol and cholesterol derivatives on hydrocarbon chain mobility in lipids

1971 • 184 citations

Synthesis and Evaluation of a Prototypal Artificial Red Cell

1985 • 158 citations

In vivo biodistribution of a radiolabeled blood substitute: 99mTc-labeled liposome-encapsulated hemoglobin in an anesthetized rabbit.

1991 • 91 citations

[18] Liposome-encapsulated hemoglobin as an artificial oxygen-carrying system

1987 • 90 citations

Surface modification of haemoglobin-containing liposomes with polyethylene glycol prevents liposome aggregation in blood plasma

1991 • 90 citations

Encapsulation of hemoglobin in phospholipid liposomes: characterization and stability

1985 • 66 citations

Synergistic toxicity of endotoxin and hemoglobin.

1986 • 63 citations

The Binding of Phosphatidylglycerol Liposomes to Rat Platelets Is Mediated by Complement

1990 • 61 citations

Hemoglobin enhances the production of tissue factor by endothelial cells in response to bacterial endotoxin

1994 • 60 citations

Lyophilized liposome encapsulated hemoglobin

1994 • 57 citations

The freeze-dried preservation of liposome encapsulated hemoglobin: A potential blood substitute

1988 • 55 citations

Complement Activation in Rats by Liposomes and Liposome-Encapsulated Hemoglobin: Evidence for Anti-lipid Antibodies and Alternative Pathway Activation

1994 • 53 citations

Cardiorespiratory effects of exchange transfusions with synthetic erythrocytes in rats

1987 • 52 citations

Characterization of hemodynamic, hematologic, and biochemical responses to administration of liposome-encapsulated hemoglobin in the conscious, freely moving rat.

1989 • 51 citations

A NEW SALUTARY RESUSCITATIVE FLUID

1992 • 50 citations

A NEW SALUTARY RESUSCITATIVE FLUID

1993 • 49 citations

Liposome-Encapsulated Hemoglobin: Oxygen Binding Properties and Respiratory Function

1988 • 47 citations

Lipid peroxidation in hemoglobin-containing liposomes. Effects of membrane phospholipid composition and cholesterol content

1986 • 41 citations

Dry storage of liposome-encapsulated hemoglobin: A blood substitute

1990 • 40 citations

Generation of toxic phospholipid(s) during oxyhemoglobin-induced peroxidation of phosphatidylcholines

1988 • 40 citations

Biological responses to liposome-encapsulated hemoglobin (LEH) are improved by a PAF antagonist.

1990 • 36 citations

Liposome-encapsulated hemoglobin as a red cell surrogate. Preparation scale-up.

1986 • 32 citations

Biological responses to exchange transfusion with liposome-encapsulated hemoglobin.

1992 • 32 citations

The Reduction of Methemoglobin Levels by Antioxidants

1988 • 29 citations

Stabilized Hemoglobin Vesicles

1994 • 29 citations

Preparation of hemoglobin-containing liposomes using octyl glucoside and octyltetraoxyethylene

1989 • 28 citations

The presence of GM1 in liposomes with entrapped doxorubicin does not prevent RES blockade

1993 • 26 citations

Circulation persistence and biodistribution of lyophilized liposome-encapsulated hemoglobin: An oxygen-carrying resuscitative fluid

1994 • 25 citations

Improved biological properties of synthetic distearoyl phosphatidyl choline-based liposome in the conscious rat.

1990 • 18 citations

Transient changes in the mononuclear phagocyte system following administration of the blood substitute liposome-encapsulated haemoglobin

1994 • 17 citations

Liposome-encapsulated hemoglobin inhibits tumor necrosis factor release from rabbit alveolar macrophages by a posttranscriptional mechanism

1992 • 17 citations

Inclusion of Ganglioside G_M1Into Liposome Encapsulated Hemoglobin Does not Extend Circulation Persistence at Clinically Relevant Doses

1994 • 16 citations

Preparation of dehydrated powder of hemoglobin vesicles

1992 • 13 citations

Effect of Neo Red Cells on Hemodynamics and Blood Gas Transport in Canine Hemorrhagic Shock and its Safety for Vital Organs

1994 • 12 citations

Effects of Liposome Encapsulated Hemoglobin on the Reticuloendothelial System

1992 • 10 citations

The Effect of Lipid Composition on the Stability of Liposomes in vivo

1979 • 8 citations

Liposome encapsulated hemoglobin: stabilization, encapsulation, and storage.

1989 • 6 citations

Circulation Profile of Technetium-99m Labeled Liposome Encapsulated Hemoglobin in a 10% or 50% Rat Hypovolemic Shock Model

1994 • 4 citations