A cross-species analysis of the cystic fibrosis transmembrane conductance regulator. Potential functional domains and regulatory sites.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

Identification of the Cystic Fibrosis Gene: Genetic Analysis

1989 • 4,105 citations

Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping

1989 • 3,180 citations

Atlas of Protein Sequence and Structure, 1972.

1973 • 2,408 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Effects of primer-template mismatches on the polymerase chain reaction: Human immunodeficiency virus type 1 model studies

1990 • 1,037 citations

Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells

1990 • 706 citations

Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer

1990 • 576 citations

Pulmonary Diseases and Disorders.

1988 • 553 citations

Generation of cAMP-Activated Chloride Currents by Expression of CFTR

1991 • 550 citations

Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance

1991 • 508 citations

Localization of cystic fibrosis locus to human chromosome 7cen–q22

1985 • 498 citations

Cystic Fibrosis Locus Defined by a Genetically Linked Polymorphic DNA Marker

1985 • 488 citations

A closely linked genetic marker for cystic fibrosis

1985 • 463 citations

Improved double-stranded DNA sequencing using the linear polymerase chain reaction

1989 • 453 citations

Identification of mutations in regions corresponding to the two putative nucleotide (ATP)-binding folds of the cystic fibrosis gene.

1990 • 433 citations

Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium

1988 • 419 citations

The Metabolic Basis of Inherited Disease.

1991 • 409 citations

A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regulator protein

1990 • 397 citations

Multiple mutations in highly conserved residues are found in mildly affected cystic fibrosis patients

1990 • 353 citations

A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands

1987 • 339 citations

Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation.

1982 • 337 citations

A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7

1985 • 332 citations

The human met oncogene is related to the tyrosine kinase oncogenes

1985 • 295 citations

Pulmonary Diseases and Disorders

1989 • 258 citations

Linkage of cystic fibrosis to two tightly linked DNA markers: joint report from a collaborative study.

1986 • 165 citations

Two Patients with Cystic Fibrosis, Nonsense Mutations in Each Cystic Fibrosis Gene, and Mild Pulmonary Disease

1990 • 146 citations

Variable deletion of exon 9 coding sequences in cystic fibrosis transmembrane conductance regulator gene mRNA transcripts in normal bronchial epithelium.

1991 • 138 citations

cDNA cloning and chromosomal assignment of the endothelin 2 gene: Vasoactive intestinal contractor peptide is rat endothelin 2

1991 • 120 citations

Three point mutations in the CFTR gene in French cystic fibrosis patients: Identification by denaturing gradient gel electrophoresis

1990 • 120 citations

Analysis of P-glycoprotein phosphorylation in HL60 cells isolated for resistance to vincristine.

1991 • 109 citations

A frame-shift mutation in the cystic fibrosis gene

1990 • 107 citations

Cloning the mouse homolog of the human cystic fibrosis transmembrane conductance regulator gene

1991 • 98 citations

Functional analysis of chimeric genes obtained by exchanging homologous domains of the mouse mdr1 and mdr2 genes.

1991 • 77 citations

A 3′ splice site consensus sequence mutation in the cystic fibrosis gene

1990 • 62 citations

Cystic fibrosis gene expression is not correlated with rectifying Cl- channels.

1991 • 59 citations

Refined linkage map of chromosome 7 in the region of the cystic fibrosis gene.

1988 • 59 citations

Two frameshift mutations in the cystic fibrosis gene.

1991 • 46 citations

Phosphotyrosine — a new protein modification

1982 • 43 citations

Full length and alternatively spliced pgp1 transcripts in multidrug-resistant Chinese hamster lung cells

1991 • 41 citations

Isolation of additional polymorphic clones from the cystic fibrosis region, using chromosome jumping from D7S8.

1989 • 25 citations