PCBs AS MICROSOMAL ENZYME INDUCERS: STRUCTURE-ACTIVITY RULES

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

Analysis of polychlorinated biphenyls (PCB) by glass capillary gas chromatography

1980 • 1,438 citations

Microsomal Triphosphopyridine Nucleotide-Cytochrome c Reductase of Liver

1962 • 909 citations

Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene.

1979 • 576 citations

Regulatory gene product of the Ah locus. Characterization of the cytosolic inducer-receptor complex and evidence for its nuclear translocation.

1979 • 401 citations

STUDIES ON THE MECHANISM OF ACTION OF THE CHLORINATED DIBENZO‐p‐DIOXINS AND RELATED COMPOUNDS*

1979 • 336 citations

Regulation of three forms of cytochrome P-450 and epoxide hydrolase in rat liver microsomes. Effects of age, sex, and induction.

1981 • 304 citations

Microsomes and Drug Oxidations

1978 • 256 citations

Separation of pure polychlorinated biphenyl isomers into two types of inducers on the basis of induction of cytochrome P-450 or P-448

1977 • 252 citations

Structural identification of polychlorinated biphenyls in commercial mixtures by gas-liquid chromatography, nuclear magnetic resonance and mass spectrometry

1971 • 211 citations

POSSIBLE CORRELATION BETWEEN INDUCTION MODES OF HEPATIC ENZYMES BY PCBs AND THEIR TOXICITY IN RATS

1979 • 173 citations

Amino acid compositions and partial amino acid sequences of three highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, or 3-methylcholanthrene.

1979 • 153 citations

Toxicological assessment of hexachlorobiphenyl isomers and 2,3,7,8-tetrachlorodibenzofuran in chicks

1976 • 153 citations

Heterogeneity of cytochrome P-450s induced by polychlorinated biphenyls.

1977 • 130 citations

Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: Structure-activity rules

1980 • 125 citations

Polychlorinated biphenyl isomers and congeners as inducers of both 3-methylcholanthrene- and phenobarbitone-type microsomal enzyme activity

1980 • 115 citations

THE STRUCTURE-ACTIVITY RELATIONSHIPS OF HALOGENATED BIPHENYLS AS ENZYME INDUCERS

1979 • 104 citations

Properties of purified liver microsomal cytochrome P450 from rats treated with the polychlorinated biphenyl mixture Aroclor 1254.

1977 • 85 citations

Toxicological assessment of hexachlorobiphenyl isomers and 2,3,7,8-tetrachlorodibenzofuran in chicks

1976 • 84 citations

THE STRUCTURE-ACTIVITY RELATIONSHIPS OF HALOGENATED BIPHENYLS AS ENZYME INDUCERS

1979 • 80 citations

Inductive effect of polychlorinated biphenyls mixture and individual isomers on the hepatic microsomal enzymes.

1978 • 75 citations

2,4,5,3′,4′,5′-hexabromobiphenyl is both a 3-methylcholanthrene-and a phenobarbital-type inducer of microsomal drug metabolizing enzymes

1978 • 64 citations

Different patterns of hepatic microsomal enzyme activity produced by administration of pure hexachlorobiphenyl isomers and hexachlorobenzene

1976 • 62 citations

Toxicological assessment of highly chlorinated biphenyl congeners retained in the Yusho patients

1979 • 53 citations

Induction of both 3-methylcholanthrene- and phenobarbitone-type microsomal enzyme activity by a single polychlorinated biphenyl isomer

1980 • 51 citations

Effects of Purified Polychlorinated Biphenyl Analogs on Chicken Reproduction

1975 • 49 citations

An improved radiochemical assay for benzo[a]pyrene monooxygenase

1977 • 46 citations

Biochemical effects of pure isomers of hexachlorobiphenyl: Fatty livers and cell structure

1979 • 44 citations

Induction of porphyrin synthesis in chick embryo liver cell culture by synthetic polychlorobiphenyl isomers

1978 • 38 citations

The binding of ethyl isocyanide by hepatic microsomal hemoprotein

1966 • 35 citations

The detection of enzyme induction by rat liver microsomes prepared by isoelectric precipitation

1979 • 31 citations

Metabolic and toxicologic evaluation of 2,3,4,3',4'-pentachlorobiphenyl in rats and mice.

1976 • 28 citations

Separation and quantitation of 3,3′,4,4′-tetrachlorobiphenyl and 3,3′,4,4′,5,5′-hexachlorobiphenyl in aroclors using florisil column chromatography and gas-liquid chromatography

1979 • 28 citations

Hepatic microsomal enzyme induction by 2, 2', 3, 3', 4, 4'- and 2, 2', 3', 4, 4', 5-hexachlorobiphenyl

1980 • 27 citations

Induction of different species of cytochrome P-450 by coplanar and noncoplanar isomers of hexachlorobiphenyl

1980 • 26 citations

The utility of the microsomal 4-chlorobiphenyl hydroxylase enzyme assay in distinguishing between phenobarbitone- and 3-methylcholanthrene-induced microsomal monooxygenases

1980 • 17 citations