Substance P and the Primary Afferent Neuron

Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals

1978 • 1,426 citations

Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones

1977 • 1,284 citations

Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation

1979 • 1,199 citations

DIRECT EVIDENCE FOR NEUROGENIC INFLAMMATION AND ITS PREVENTION BY DENERVATION AND BY PRETREATMENT WITH CAPSAICIN

1967 • 1,100 citations

Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat

1976 • 758 citations

Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo

1980 • 697 citations

Effects of substance P on functionally identified units in cat spinal cord

1976 • 655 citations

DECREASE OF SUBSTANCE P IN PRIMARY AFFERENT NEURONES AND IMPAIRMENT OF NEUROGENIC PLASMA EXTRAVASATION BY CAPSAICIN

1980 • 595 citations

Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration.

1979 • 546 citations

On the origin from the spinal cord of the vaso‐dilator fibres of the hind‐limb, and on the nature of these fibres1

1901 • 480 citations

Substance P: Depletion in the dorsal horn of rat spinal cord after section of the peripheral processes of primary sensory neurons

1979 • 455 citations

Regional distribution of substance P in the spinal cord and nerve roots of the cat and the effect of dorsal root section

1975 • 443 citations

Substance P release from spinal cord slices by capsaicin

1979 • 376 citations

Effect of substance P in cat dorsal horn neurones activated by noxious stimuli

1977 • 362 citations

Differential effects of capsaicin on the content of somatostatin, substance P, and neurotensin in the nervous system of the rat

1981 • 317 citations

Substance P: Release on trigeminal nerve stimulation, effects in the eye

1979 • 315 citations

Release of Substance P‐like Immunoreactivity from the Dental Pulp

1977 • 272 citations

The effect of peripheral nerve injury on dorsal root potentials and on transmission of afferent signals into the spinal cord

1981 • 249 citations

Axonal transport of substance P in the vagus and sciatic nerves of the guinea pig

1980 • 241 citations

The electron microscopic localization of methionine-enkephalin within the superficial layers (I and II) of the spinal cord

1980 • 234 citations

Substance pin spinal cord dorsal horn decreases following peripheral nerve injury

1981 • 224 citations

Immunoreactive substance P in sympathetic ganglia: Distribution and sensitivity towards capsaicin

1981 • 221 citations

Requirement of nerve growth factor for development of substance P-containing sensory neurones

1980 • 194 citations

Increase of substance P in primary afferent nerves during chronic pain

1981 • 194 citations

Substance P in the vagus nerve

1979 • 184 citations

The permanent anatomical effects of neonatal capsaicin on somatosensory nerves.

1980 • 180 citations

Mapping and plasticity of acid phosphatase afferents in the rat dorsal horn

1980 • 165 citations

Release of histamine by substance P

1981 • 165 citations

Effect of capsaicin pretreatment on capsaicin-evoked release of immunoreactive somatostatin and substance P from primary sensory neurons

1981 • 161 citations

Behavioral evidence that substance P may be a spinal cord sensory neurotransmitter

1981 • 156 citations

Immunohistochemical studies of peptidergic neurons in the dorsal horn of the spinal cord.

1980 • 148 citations

Pharmacologic actions of capsaicin: Apparent involvement of substance P and serotonin

1979 • 141 citations

Evidence suggesting a transmitter or neuromodulatory role for substance P at the first synapse of the baroreceptor reflex

1980 • 141 citations

Nociceptive threshold after neonatal capsaicin treatment

1979 • 139 citations

Indirect evidence for presynaptic location of opiate receptors on chemosensitive primary sensory neurones

1979 • 134 citations

Substance P: A Polypeptide of Possible Physiological Significance, Especially Within the Nervous System

1962 • 125 citations

Distribution of capsaicin in rat tissues after systemic administration

1982 • 99 citations

Human spinal neurons: Innervation by both substance p and enkephalin

1981 • 98 citations

Time course of capsaicin-induced functional impairments in comparison with changes in neuronal substance P content

1981 • 97 citations

Axonal Transport of Neuropeptides in the Cervical Vagus Nerve of the Rat

1980 • 86 citations

Cycloheximide-sensitive synthesis of substance P by isolated dorsal root ganglia

1980 • 84 citations

Peptides as putative excitatory neurotransmitters: carnosine, enkephalin, substance P and TRH

1980 • 84 citations

Substance P immunoreactive neurons following neonatal administration of capsaicin

1981 • 82 citations

Postocclusive cutaneous vasodilatation mediated by substance P

1981 • 79 citations

Cellular localization of peptides in neural structures

1980 • 73 citations

Die Pathogenese der trophischen Gewebsschäden nach der Nervenverletzung

1919 • 71 citations

Histamine-Induced release of arachidonic acid and of prostaglandins in the peripheral vascular bed

1980 • 71 citations

Determination of capsaicin in tissues and separation of capsaicin analogues by high-performance liquid chromatography

1981 • 63 citations

Pharmacological characterization of scratching behaviour induced by intracranial injection of substance p and somatostatin

1981 • 62 citations

Latencies of chemically evoked discharges in human cutaneous nociceptors and of the concurrent subjective sensations

1980 • 59 citations

Effects of single doses of capsaicin on nociceptive thresholds in the rodent

1981 • 57 citations

Morphine does not antagonize the substance P mediated excitation of dorsal horn neurons

1980 • 56 citations

Dauerausschaltung der chemischen Schmerzempfindlichkeit durch Capsaicin

1959 • 54 citations

Regulation of neuropeptide release

1980 • 49 citations

Identification by high-performance liquid chromatography of immunoreactive substance P released from isolated rat spinal cord

1980 • 48 citations

Lack of algesic effect of substance P on paravascular pain receptors

1977 • 46 citations

In vitro release of substance P from spinal cord slices by capsaicin congeners

1981 • 41 citations

Effects of antibodies against nerve growth factor on the postnatal development of substance P-containing sensory neurons

1982 • 32 citations

The Action of Substance P on Motoneurons of the Isolated Rat Spinal Cord

1979 • 13 citations